hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00010
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BRK1 | Protein BRICK1 (BRK1) | UniProt NCBI |
| ABI2 | Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1) | UniProt NCBI |
| CYFIP1 | Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:2000601 | 1.81637152046e-06 | 1.0 | ABI2 CYFIP1 BRK1 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| REAC:R-HSA-5663213 | 2.94261178253e-06 | 1.0 | ABI2 CYFIP1 BRK1 | RHO GTPases Activate WASPs and WAVEs |
| GO:0031209 | 5.08584025729e-06 | 1.0 | ABI2 CYFIP1 BRK1 | SCAR complex |
| GO:0051127 | 7.62876038594e-06 | 1.0 | ABI2 CYFIP1 BRK1 | positive regulation of actin nucleation |
| REAC:R-HSA-2029482 | 1.46159459799e-05 | 1.0 | ABI2 CYFIP1 BRK1 | Regulation of actin dynamics for phagocytic cup formation |
| GO:0034315 | 1.99800867251e-05 | 1.0 | ABI2 CYFIP1 BRK1 | regulation of Arp2/3 complex-mediated actin nucleation |
| KEGG:04810 | 3.2250969458e-05 | 1.0 | ABI2 CYFIP1 BRK1 | Regulation of actin cytoskeleton |
| CORUM:186 | 3.35555483123e-05 | 0.666666666667 | BRK1 CYFIP1 | Wave-2 complex |
| REAC:R-HSA-2029480 | 3.69388822082e-05 | 1.0 | ABI2 CYFIP1 BRK1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 5.46192807335e-05 | 1.0 | ABI2 CYFIP1 BRK1 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 7.05188258943e-05 | 1.0 | ABI2 CYFIP1 BRK1 | Signaling by VEGF |
| GO:0051125 | 7.41079580349e-05 | 1.0 | ABI2 CYFIP1 BRK1 | regulation of actin nucleation |
| GO:0016601 | 0.000208882724853 | 1.0 | ABI2 CYFIP1 BRK1 | Rac protein signal transduction |
| GO:0034314 | 0.00023612829766 | 1.0 | ABI2 CYFIP1 BRK1 | Arp2/3 complex-mediated actin nucleation |
| GO:0045010 | 0.000408229499224 | 1.0 | ABI2 CYFIP1 BRK1 | actin nucleation |
| GO:0048365 | 0.00178004409005 | 1.0 | ABI2 CYFIP1 BRK1 | Rac GTPase binding |
| REAC:R-HSA-195258 | 0.00218937240413 | 1.0 | ABI2 CYFIP1 BRK1 | RHO GTPase Effectors |
| GO:0030838 | 0.00326856055107 | 1.0 | ABI2 CYFIP1 BRK1 | positive regulation of actin filament polymerization |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | ABI2 CYFIP1 BRK1 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-194315 | 0.00591618280835 | 1.0 | ABI2 CYFIP1 BRK1 | Signaling by Rho GTPases |
| KEGG:05130 | 0.00692087445383 | 0.666666666667 | BRK1 CYFIP1 | Pathogenic Escherichia coli infection |
| WP:WP51 | 0.0082449684177 | 0.666666666667 | ABI2 BRK1 | Regulation of Actin Cytoskeleton |
| GO:0032273 | 0.0110330947082 | 1.0 | ABI2 CYFIP1 BRK1 | positive regulation of protein polymerization |
| GO:0017048 | 0.0125706532002 | 1.0 | ABI2 CYFIP1 BRK1 | Rho GTPase binding |
| GO:0030833 | 0.0142448028307 | 1.0 | ABI2 CYFIP1 BRK1 | regulation of actin filament polymerization |
| GO:0008064 | 0.0206993698472 | 1.0 | ABI2 CYFIP1 BRK1 | regulation of actin polymerization or depolymerization |
| GO:0030832 | 0.0212638981157 | 1.0 | ABI2 CYFIP1 BRK1 | regulation of actin filament length |
| GO:0030041 | 0.0242409310378 | 1.0 | ABI2 CYFIP1 BRK1 | actin filament polymerization |
| GO:0030027 | 0.0242409310378 | 1.0 | ABI2 CYFIP1 BRK1 | lamellipodium |
| GO:0008154 | 0.0406485782564 | 1.0 | ABI2 CYFIP1 BRK1 | actin polymerization or depolymerization |
| GO:1902905 | 0.0415322430011 | 1.0 | ABI2 CYFIP1 BRK1 | positive regulation of supramolecular fiber organization |
| GO:0032271 | 0.0451949561721 | 1.0 | ABI2 CYFIP1 BRK1 | regulation of protein polymerization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ABI2 | CYFIP1 | 0.951 | 0.858 | hein_WMM bioplex (ABI2) bioplex_WMM youn_WMM |
| ABI2 | BRK1 | 0.574 | 0.656 | hein_WMM bioplex (ABI2) bioplex_WMM |
| BRK1 | CYFIP1 | 0.02 | 0.188 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_00010 has an average edge precision of 0.567 which is ranked 2093 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BRK1 | HuMAP2_00010 HuMAP2_00378 HuMAP2_06838 |
| ABI2 | HuMAP2_00010 HuMAP2_00378 HuMAP2_06838 |
| CYFIP1 | HuMAP2_00010 HuMAP2_00378 HuMAP2_03322 HuMAP2_06838 |