hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00024

Confidence: Medium High

Genename	Protein Name	Links
CHMP5	Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)	UniProt NCBI
CHMP4A	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1)	UniProt NCBI
DHX38	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)	UniProt NCBI
CHMP4B	Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)	UniProt NCBI
STMN4	Stathmin-4 (Stathmin-like protein B3) (RB3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1186	1.62061692851e-07	0.6	CHMP4B CHMP5 CHMP4A	ESCRT-III complex
REAC:R-HSA-162588	8.88541585136e-06	0.6	CHMP4B CHMP5 CHMP4A	Budding and maturation of HIV virion
REAC:R-HSA-917729	1.21879917622e-05	0.6	CHMP4B CHMP5 CHMP4A	Endosomal Sorting Complex Required For Transport (ESCRT)
KEGG:04217	0.00048888248268	0.6	CHMP4B CHMP5 CHMP4A	Necroptosis
GO:0061952	0.000616695699567	0.6	CHMP4B CHMP5 CHMP4A	midbody abscission
REAC:R-HSA-162599	0.00102865345201	0.6	CHMP4B CHMP5 CHMP4A	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	0.00136170542712	0.6	CHMP4B CHMP5 CHMP4A	HIV Life Cycle
GO:1902410	0.00139593056214	0.6	CHMP4B CHMP5 CHMP4A	mitotic cytokinetic process
KEGG:04144	0.00171388219445	0.6	CHMP4B CHMP5 CHMP4A	Endocytosis
GO:0046755	0.00208420080219	0.6	CHMP4B CHMP5 CHMP4A	viral budding
GO:0036258	0.00367721278555	0.6	CHMP4B CHMP5 CHMP4A	multivesicular body assembly
GO:0036257	0.00407078924856	0.6	CHMP4B CHMP5 CHMP4A	multivesicular body organization
REAC:R-HSA-9615710	0.00472180750517	0.4	CHMP4A CHMP4B	Microautophagy
REAC:R-HSA-162906	0.00484900153486	0.6	CHMP4B CHMP5 CHMP4A	HIV Infection
GO:0032506	0.005924931483	0.6	CHMP4B CHMP5 CHMP4A	cytokinetic process
GO:0019068	0.00826983957236	0.6	CHMP4B CHMP5 CHMP4A	virion assembly
GO:0007080	0.0119783897598	0.6	CHMP4B CHMP5 CHMP4A	mitotic metaphase plate congression
REAC:R-HSA-5663205	0.0198891654246	0.6	CHMP4B CHMP5 CHMP4A	Infectious disease
GO:0051310	0.0237016209836	0.6	CHMP4B CHMP5 CHMP4A	metaphase plate congression
GO:0051303	0.0308999432136	0.6	CHMP4B CHMP5 CHMP4A	establishment of chromosome localization
GO:0050000	0.0324949337356	0.6	CHMP4B CHMP5 CHMP4A	chromosome localization
GO:0000281	0.0432266328844	0.6	CHMP4B CHMP5 CHMP4A	mitotic cytokinesis
GO:0007032	0.0493791608738	0.6	CHMP4B CHMP5 CHMP4A	endosome organization
REAC:R-HSA-1632852	0.0499209306556	0.4	CHMP4A CHMP4B	Macroautophagy

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CHMP5	CHMP4A	0.988	0.901	hein_WMM bioplex_WMM Guru fraction
CHMP5	CHMP4B	0.944	0.856	hein_WMM bioplex (CHMP5) bioplex_WMM Guru youn_WMM hein (CHMP4B) gupta_WMM fraction
CHMP5	STMN4	0.153	0.411	bioplex (CHMP5) bioplex_WMM
CHMP5	DHX38	0.096	0.357	youn_WMM gupta_WMM fraction
CHMP4B	DHX38	0.007	0.003	youn_WMM gupta_WMM WMM_only
CHMP4B	STMN4	0.007	0.006	bioplex_WMM WMM_only
CHMP4A	CHMP4B	0.006	0.008	hein_WMM bioplex_WMM hein (CHMP4B) treiber_WMM
CHMP4A	DHX38	0.0	0.007	fraction

Images

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Complex HuMAP2_00024 has an average edge precision of 0.319 which is ranked 4361 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CHMP5	HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627
CHMP4A	HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627
DHX38	HuMAP2_00024 HuMAP2_05448
CHMP4B	HuMAP2_00024 HuMAP2_00246 HuMAP2_01637 HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528
STMN4	HuMAP2_00024 HuMAP2_04528 HuMAP2_06627

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00024