hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00037
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) | UniProt NCBI |
| PRKACB | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-442720 | 9.21757904306e-05 | 1.0 | PRKAR1A PRKACB | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| WP:WP3869 | 9.42630769247e-05 | 1.0 | PRKAR1A PRKACB | Cannabinoid receptor signaling |
| WP:WP2012 | 0.000121088932808 | 1.0 | PRKAR1A PRKACB | miRs in Muscle Cell Differentiation |
| WP:WP3965 | 0.000140835743389 | 1.0 | PRKAR1A PRKACB | Lipid Metabolism Pathway |
| REAC:R-HSA-163615 | 0.000201110815485 | 1.0 | PRKAR1A PRKACB | PKA activation |
| REAC:R-HSA-164378 | 0.000227925590883 | 1.0 | PRKAR1A PRKACB | PKA activation in glucagon signalling |
| REAC:R-HSA-111931 | 0.000256416289743 | 1.0 | PRKAR1A PRKACB | PKA-mediated phosphorylation of CREB |
| REAC:R-HSA-180024 | 0.000424008635981 | 1.0 | PRKAR1A PRKACB | DARPP-32 events |
| REAC:R-HSA-163359 | 0.000779304410004 | 1.0 | PRKAR1A PRKACB | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-111997 | 0.000884887588134 | 1.0 | PRKAR1A PRKACB | CaM pathway |
| REAC:R-HSA-111933 | 0.000884887588134 | 1.0 | PRKAR1A PRKACB | Calmodulin induced events |
| REAC:R-HSA-111996 | 0.000997174460113 | 1.0 | PRKAR1A PRKACB | Ca-dependent events |
| REAC:R-HSA-381676 | 0.000997174460113 | 1.0 | PRKAR1A PRKACB | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-432040 | 0.00111616502594 | 1.0 | PRKAR1A PRKACB | Vasopressin regulates renal water homeostasis via Aquaporins |
| KEGG:04910 | 0.00113070596705 | 1.0 | PRKAR1A PRKACB | Insulin signaling pathway |
| REAC:R-HSA-1489509 | 0.00124185928562 | 1.0 | PRKAR1A PRKACB | DAG and IP3 signaling |
| REAC:R-HSA-445717 | 0.00124185928562 | 1.0 | PRKAR1A PRKACB | Aquaporin-mediated transport |
| WP:WP4540 | 0.00139382676196 | 1.0 | PRKAR1A PRKACB | Pathways Regulating Hippo Signaling |
| WP:WP35 | 0.00139382676196 | 1.0 | PRKAR1A PRKACB | G Protein Signaling Pathways |
| WP:WP4541 | 0.00191916643968 | 1.0 | PRKAR1A PRKACB | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-112043 | 0.00213680241453 | 1.0 | PRKAR1A PRKACB | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.00222227451111 | 1.0 | PRKAR1A PRKACB | G-protein mediated events |
| WP:WP536 | 0.00266023070847 | 1.0 | PRKAR1A PRKACB | Calcium Regulation in the Cardiac Cell |
| WP:WP706 | 0.0030283410642 | 1.0 | PRKAR1A PRKACB | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| WP:WP289 | 0.00317253003958 | 1.0 | PRKAR1A PRKACB | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-422356 | 0.00393171644273 | 1.0 | PRKAR1A PRKACB | Regulation of insulin secretion |
| REAC:R-HSA-438064 | 0.00440432685912 | 1.0 | PRKAR1A PRKACB | Post NMDA receptor activation events |
| REAC:R-HSA-442755 | 0.00584226918984 | 1.0 | PRKAR1A PRKACB | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-111885 | 0.00612550025498 | 1.0 | PRKAR1A PRKACB | Opioid Signalling |
| REAC:R-HSA-163685 | 0.00780309964082 | 1.0 | PRKAR1A PRKACB | Integration of energy metabolism |
| REAC:R-HSA-5610787 | 0.0102315127378 | 1.0 | PRKAR1A PRKACB | Hedgehog 'off' state |
| REAC:R-HSA-5358351 | 0.0167776697818 | 1.0 | PRKAR1A PRKACB | Signaling by Hedgehog |
| REAC:R-HSA-983231 | 0.0210512746109 | 1.0 | PRKAR1A PRKACB | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-112314 | 0.0255159347147 | 1.0 | PRKAR1A PRKACB | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-112315 | 0.0429891127334 | 1.0 | PRKAR1A PRKACB | Transmission across Chemical Synapses |
| HP:0006769 | 0.0497341708567 | 0.5 | PRKAR1A | Myxoid subcutaneous tumors |
| HP:0006691 | 0.0497341708567 | 0.5 | PRKAR1A | Pulmonic valve myxoma |
| HP:0005587 | 0.0497341708567 | 0.5 | PRKAR1A | Profuse pigmented skin lesions |
| HP:0008225 | 0.0497341708567 | 0.5 | PRKAR1A | Thyroid follicular hyperplasia |
| HP:0005756 | 0.0497341708567 | 0.5 | PRKAR1A | Neonatal epiphyseal stippling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKACB | PRKAR1A | 1.0 | 0.949 | hein_WMM bioplex (PRKACB,PRKAR1A) bioplex_WMM Guru hein (PRKACB) fraction |
Images
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Complex HuMAP2_00037 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKAR1A | HuMAP2_00037 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706 |
| PRKACB | HuMAP2_00037 HuMAP2_01784 HuMAP2_01832 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 |