hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00041

Confidence: Medium

Genename	Protein Name	Links
SRSF5	Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)	UniProt NCBI
RRP9	U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K)	UniProt NCBI
ZC3H8	Zinc finger CCCH domain-containing protein 8	UniProt NCBI
NOP10	H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)	UniProt NCBI
KRR1	KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2) (KRR-R motif-containing protein 1) (Rev-interacting protein 1) (Rip-1)	UniProt NCBI
LARP7	La-related protein 7 (La ribonucleoprotein domain family member 7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)	UniProt NCBI
GAR1	H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)	UniProt NCBI
LIN28B	Protein lin-28 homolog B (Lin-28B)	UniProt NCBI
POP1	Ribonucleases P/MRP protein subunit POP1 (hPOP1) (EC 3.1.26.5)	UniProt NCBI
DKC1	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	UniProt NCBI
ZBTB11	Zinc finger and BTB domain-containing protein 11	UniProt NCBI
ZCCHC9	Zinc finger CCHC domain-containing protein 9	UniProt NCBI
CTCF	Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog)	UniProt NCBI
HP1BP3	Heterochromatin protein 1-binding protein 3 (Protein HP1-BP74)	UniProt NCBI
C8orf33	UPF0488 protein C8orf33	UniProt NCBI
ZCRB1	Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005732	4.12504146361e-07	0.3125	DKC1 NOP10 POP1 RRP9 GAR1	small nucleolar ribonucleoprotein complex
REAC:R-HSA-6790901	1.02668561154e-06	0.3125	DKC1 NOP10 RRP9 GAR1 KRR1	rRNA modification in the nucleus and cytosol
CORUM:6245	1.64387648611e-06	0.1875	DKC1 NOP10 GAR1	Telomerase holoenzyme
REAC:R-HSA-8953854	3.30893244345e-05	0.5	SRSF5 POP1 DKC1 RRP9 KRR1 ZCRB1 GAR1 NOP10	Metabolism of RNA
GO:0003723	3.6763794621e-05	0.75	DKC1 LIN28B NOP10 POP1 ZC3H8 RRP9 LARP7 KRR1 ZCRB1 ZCCHC9 SRSF5 GAR1	RNA binding
KEGG:03008	6.01460781143e-05	0.25	DKC1 NOP10 POP1 GAR1	Ribosome biogenesis in eukaryotes
GO:0003676	6.73252296691e-05	0.875	DKC1 LIN28B HP1BP3 NOP10 POP1 ZC3H8 RRP9 LARP7 CTCF KRR1 ZCRB1 ZCCHC9 SRSF5 GAR1	nucleic acid binding
GO:0090661	0.000203300410527	0.1875	DKC1 NOP10 GAR1	box H/ACA telomerase RNP complex
GO:0072589	0.000203300410527	0.1875	DKC1 NOP10 GAR1	box H/ACA scaRNP complex
GO:0031429	0.000203300410527	0.1875	DKC1 NOP10 GAR1	box H/ACA snoRNP complex
GO:0072588	0.000203300410527	0.1875	DKC1 NOP10 GAR1	box H/ACA RNP complex
GO:0034513	0.000203300410527	0.1875	DKC1 NOP10 GAR1	box H/ACA snoRNA binding
REAC:R-HSA-8868773	0.000348326113419	0.3125	DKC1 NOP10 RRP9 GAR1 KRR1	rRNA processing in the nucleus and cytosol
GO:0030515	0.000388371745793	0.25	DKC1 NOP10 RRP9 GAR1	snoRNA binding
REAC:R-HSA-72312	0.00044797460179	0.3125	DKC1 NOP10 RRP9 GAR1 KRR1	rRNA processing
GO:0005730	0.000816106601504	0.5625	LIN28B SRSF5 POP1 DKC1 CTCF RRP9 KRR1 GAR1 NOP10	nucleolus
GO:0034470	0.000860220533944	0.4375	LIN28B KRR1 DKC1 RRP9 POP1 GAR1 NOP10	ncRNA processing
GO:0006396	0.00106212748493	0.5625	LIN28B SRSF5 POP1 DKC1 RRP9 KRR1 ZCRB1 GAR1 NOP10	RNA processing
GO:1901363	0.00136780533033	0.875	DKC1 LIN28B HP1BP3 NOP10 POP1 ZC3H8 RRP9 LARP7 CTCF KRR1 ZCRB1 ZCCHC9 SRSF5 GAR1	heterocyclic compound binding
GO:0097159	0.00172856067658	0.875	DKC1 LIN28B HP1BP3 NOP10 POP1 ZC3H8 RRP9 LARP7 CTCF KRR1 ZCRB1 ZCCHC9 SRSF5 GAR1	organic cyclic compound binding
GO:0031118	0.001775386605	0.1875	DKC1 NOP10 GAR1	rRNA pseudouridine synthesis
HP:0002165	0.00270324518819	0.125	NOP10 DKC1	Pterygium of nails
GO:0015030	0.00287061410376	0.25	DKC1 ZC3H8 GAR1 NOP10	Cajal body
GO:0034660	0.00451451118887	0.4375	LIN28B KRR1 DKC1 RRP9 POP1 GAR1 NOP10	ncRNA metabolic process
GO:0001522	0.014450541162	0.1875	DKC1 NOP10 GAR1	pseudouridine synthesis
GO:0031981	0.0202272263346	0.875	DKC1 LIN28B HP1BP3 POP1 ZC3H8 ZBTB11 RRP9 LARP7 CTCF KRR1 ZCRB1 NOP10 SRSF5 GAR1	nuclear lumen
GO:0005654	0.0280611116533	0.8125	DKC1 HP1BP3 POP1 ZC3H8 ZBTB11 RRP9 LARP7 CTCF KRR1 ZCRB1 NOP10 SRSF5 GAR1	nucleoplasm
GO:0044452	0.0320204084986	0.3125	DKC1 NOP10 POP1 RRP9 GAR1	nucleolar part
GO:0006364	0.0392925449939	0.3125	DKC1 NOP10 RRP9 GAR1 KRR1	rRNA processing
GO:0044428	0.0476491419728	0.875	DKC1 LIN28B HP1BP3 POP1 ZC3H8 ZBTB11 RRP9 LARP7 CTCF KRR1 ZCRB1 NOP10 SRSF5 GAR1	nuclear part

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GAR1	DKC1	1.0	0.949	hein_WMM bioplex (DKC1,GAR1) bioplex_WMM youn_WMM hein (GAR1) Malo fraction treiber_WMM
NOP10	GAR1	1.0	0.949	hein_WMM bioplex (GAR1) bioplex_WMM hein (GAR1) fraction treiber_WMM
HP1BP3	DKC1	1.0	0.949	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NOP10	DKC1	1.0	0.949	hein_WMM bioplex (DKC1) bioplex_WMM gupta_WMM fraction treiber_WMM
HP1BP3	GAR1	1.0	0.949	bioplex_WMM youn_WMM fraction
LARP7	DKC1	0.999	0.946	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
CTCF	DKC1	0.997	0.93	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
CTCF	HP1BP3	0.996	0.928	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
LARP7	CTCF	0.986	0.901	bioplex_WMM youn_WMM fraction treiber_WMM
LARP7	GAR1	0.986	0.9	bioplex_WMM youn_WMM fraction treiber_WMM
HP1BP3	POP1	0.939	0.851	hein_WMM bioplex_WMM youn_WMM fraction treiber_WMM
CTCF	GAR1	0.911	0.834	bioplex_WMM youn_WMM fraction
LARP7	HP1BP3	0.807	0.767	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
KRR1	POP1	0.727	0.735	hein_WMM bioplex_WMM youn_WMM fraction
POP1	DKC1	0.546	0.643	bioplex_WMM youn_WMM fraction treiber_WMM
RRP9	DKC1	0.473	0.608	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
ZC3H8	CTCF	0.417	0.573	bioplex (ZC3H8) bioplex_WMM
ZC3H8	C8orf33	0.35	0.537	bioplex (ZC3H8) bioplex_WMM
ZC3H8	LIN28B	0.318	0.509	bioplex (ZC3H8) bioplex_WMM
ZC3H8	LARP7	0.252	0.477	bioplex (ZC3H8) bioplex_WMM
ZC3H8	ZCRB1	0.204	0.454	bioplex (ZC3H8,ZCRB1) bioplex_WMM
GAR1	POP1	0.145	0.408	bioplex_WMM youn_WMM fraction
ZC3H8	GAR1	0.126	0.399	bioplex (ZC3H8) bioplex_WMM
LARP7	ZCRB1	0.059	0.328	bioplex (ZCRB1) bioplex_WMM youn_WMM treiber_WMM
SRSF5	DKC1	0.058	0.325	bioplex_WMM youn_WMM fraction treiber_WMM
KRR1	ZCRB1	0.055	0.305	bioplex (ZCRB1) bioplex_WMM
ZBTB11	ZCRB1	0.047	0.292	bioplex (ZCRB1) bioplex_WMM
CTCF	ZCRB1	0.039	0.263	bioplex (ZCRB1) bioplex_WMM
SRSF5	POP1	0.037	0.264	bioplex_WMM youn_WMM fraction
KRR1	DKC1	0.037	0.267	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
ZCCHC9	ZCRB1	0.031	0.241	bioplex (ZCRB1) bioplex_WMM
HP1BP3	ZCRB1	0.031	0.239	bioplex (ZCRB1) bioplex_WMM youn_WMM
LIN28B	ZCRB1	0.03	0.237	bioplex (ZCRB1) bioplex_WMM
ZC3H8	KRR1	0.029	0.23	bioplex_WMM WMM_only
DKC1	ZCRB1	0.027	0.229	bioplex (ZCRB1) bioplex_WMM youn_WMM
GAR1	ZCRB1	0.026	0.219	bioplex (ZCRB1) bioplex_WMM treiber_WMM
KRR1	ZCCHC9	0.025	0.217	bioplex_WMM youn_WMM WMM_only
NOP10	HP1BP3	0.024	0.215	hein_WMM bioplex_WMM gupta_WMM fraction
KRR1	LARP7	0.022	0.204	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
KRR1	HP1BP3	0.022	0.199	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
LARP7	POP1	0.017	0.171	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZBTB11	KRR1	0.017	0.173	bioplex_WMM WMM_only
ZC3H8	ZCCHC9	0.017	0.173	bioplex_WMM WMM_only
POP1	ZCRB1	0.015	0.148	bioplex (ZCRB1) bioplex_WMM
KRR1	GAR1	0.014	0.137	bioplex_WMM youn_WMM WMM_only treiber_WMM
NOP10	ZCRB1	0.014	0.141	bioplex (ZCRB1) bioplex_WMM
ZCCHC9	CTCF	0.013	0.142	bioplex_WMM WMM_only
ZCCHC9	LARP7	0.013	0.151	bioplex_WMM WMM_only
ZC3H8	HP1BP3	0.013	0.152	bioplex (ZC3H8) bioplex_WMM
ZBTB11	HP1BP3	0.013	0.153	bioplex_WMM youn_WMM WMM_only
ZBTB11	DKC1	0.013	0.154	bioplex_WMM youn_WMM WMM_only
ZBTB11	LARP7	0.013	0.152	bioplex_WMM youn_WMM WMM_only
ZBTB11	GAR1	0.013	0.148	bioplex_WMM WMM_only
ZCCHC9	LIN28B	0.012	0.149	bioplex_WMM WMM_only
ZBTB11	ZC3H8	0.012	0.147	bioplex_WMM WMM_only
ZCCHC9	HP1BP3	0.011	0.133	bioplex_WMM youn_WMM WMM_only
CTCF	LIN28B	0.011	0.133	bioplex_WMM youn_WMM WMM_only
CTCF	POP1	0.011	0.133	bioplex_WMM youn_WMM WMM_only
HP1BP3	LIN28B	0.011	0.141	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZCCHC9	POP1	0.011	0.14	bioplex_WMM youn_WMM WMM_only
ZBTB11	POP1	0.011	0.145	bioplex_WMM WMM_only
RRP9	KRR1	0.011	0.144	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZCCHC9	DKC1	0.011	0.142	bioplex_WMM youn_WMM WMM_only
KRR1	CTCF	0.011	0.146	bioplex_WMM youn_WMM WMM_only
NOP10	POP1	0.01	0.131	hein_WMM bioplex_WMM WMM_only
LIN28B	POP1	0.01	0.133	bioplex_WMM youn_WMM WMM_only
KRR1	LIN28B	0.01	0.13	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZBTB11	CTCF	0.01	0.125	bioplex_WMM WMM_only
RRP9	ZCCHC9	0.01	0.121	bioplex_WMM youn_WMM WMM_only
LIN28B	DKC1	0.009	0.114	bioplex_WMM youn_WMM WMM_only treiber_WMM
SRSF5	ZCRB1	0.009	0.102	bioplex (ZCRB1) bioplex_WMM youn_WMM
LARP7	LIN28B	0.009	0.107	bioplex_WMM youn_WMM WMM_only treiber_WMM
RRP9	LARP7	0.009	0.1	bioplex_WMM youn_WMM WMM_only treiber_WMM
C8orf33	POP1	0.009	0.089	hein_WMM bioplex_WMM WMM_only
ZBTB11	ZCCHC9	0.008	0.093	bioplex_WMM WMM_only
ZBTB11	LIN28B	0.008	0.087	bioplex_WMM WMM_only
NOP10	KRR1	0.008	0.09	bioplex_WMM WMM_only
NOP10	LARP7	0.008	0.073	bioplex_WMM WMM_only treiber_WMM
GAR1	LIN28B	0.008	0.06	bioplex_WMM youn_WMM WMM_only treiber_WMM
RRP9	CTCF	0.008	0.05	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RRP9	HP1BP3	0.008	0.034	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
NOP10	SRSF5	0.008	0.023	bioplex_WMM WMM_only
HP1BP3	C8orf33	0.008	0.023	bioplex_WMM WMM_only
CTCF	C8orf33	0.008	0.024	bioplex_WMM WMM_only
ZC3H8	POP1	0.007	0.008	bioplex_WMM WMM_only
ZBTB11	SRSF5	0.007	0.008	bioplex_WMM youn_WMM WMM_only
RRP9	POP1	0.007	0.01	bioplex_WMM youn_WMM WMM_only
ZBTB11	C8orf33	0.007	0.012	bioplex_WMM WMM_only
NOP10	ZCCHC9	0.007	0.004	bioplex_WMM WMM_only
SRSF5	C8orf33	0.007	0.006	bioplex_WMM WMM_only
C8orf33	ZCRB1	0.007	0.009	bioplex_WMM WMM_only
NOP10	LIN28B	0.007	0.01	bioplex_WMM WMM_only treiber_WMM
ZCCHC9	GAR1	0.007	0.005	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZBTB11	NOP10	0.007	0.004	bioplex_WMM WMM_only
NOP10	C8orf33	0.007	0.003	hein_WMM bioplex_WMM WMM_only
SRSF5	ZCCHC9	0.007	0.006	bioplex_WMM WMM_only
SRSF5	KRR1	0.007	0.003	bioplex_WMM youn_WMM WMM_only treiber_WMM
GAR1	C8orf33	0.007	0.004	bioplex_WMM WMM_only
ZCCHC9	C8orf33	0.007	0.004	bioplex_WMM WMM_only
ZC3H8	NOP10	0.007	0.005	bioplex_WMM WMM_only
KRR1	C8orf33	0.006	0.001	bioplex_WMM WMM_only
SRSF5	GAR1	0.006	0.006	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZC3H8	SRSF5	0.006	0.004	bioplex_WMM WMM_only
C8orf33	DKC1	0.006	0.003	bioplex_WMM WMM_only
LARP7	C8orf33	0.006	0.01	bioplex_WMM WMM_only
NOP10	RRP9	0.006	0.006	bioplex_WMM WMM_only
ZBTB11	RRP9	0.006	0.01	bioplex_WMM WMM_only
SRSF5	LIN28B	0.005	0.009	bioplex_WMM youn_WMM WMM_only treiber_WMM
LIN28B	C8orf33	0.005	0.013	bioplex_WMM WMM_only
SRSF5	CTCF	0.005	0.01	bioplex_WMM WMM_only
RRP9	LIN28B	0.005	0.011	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZC3H8	RRP9	0.005	0.009	bioplex_WMM WMM_only
RRP9	GAR1	0.005	0.009	bioplex_WMM youn_WMM WMM_only
RRP9	ZCRB1	0.005	0.008	bioplex (ZCRB1) bioplex_WMM
SRSF5	LARP7	0.005	0.012	bioplex_WMM youn_WMM WMM_only treiber_WMM
RRP9	C8orf33	0.005	0.015	bioplex_WMM WMM_only
SRSF5	HP1BP3	0.004	0.011	bioplex_WMM youn_WMM WMM_only treiber_WMM
RRP9	SRSF5	0.003	0.007	bioplex_WMM youn_WMM WMM_only treiber_WMM
ZC3H8	DKC1	0.003	0.011	bioplex (ZC3H8) bioplex_WMM
NOP10	CTCF	0.0	0.007	bioplex_WMM fraction

Images

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Complex HuMAP2_00041 has an average edge precision of 0.225 which is ranked 5784 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SRSF5	HuMAP2_00041 HuMAP2_00845 HuMAP2_02572 HuMAP2_03584 HuMAP2_04668
RRP9	HuMAP2_00041 HuMAP2_00762 HuMAP2_01863 HuMAP2_02614 HuMAP2_02899
ZC3H8	HuMAP2_00041 HuMAP2_01512 HuMAP2_01841 HuMAP2_02349 HuMAP2_02949
NOP10	HuMAP2_00041 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_06551
KRR1	HuMAP2_00041 HuMAP2_01338 HuMAP2_01512 HuMAP2_02349 HuMAP2_04618
LARP7	HuMAP2_00041 HuMAP2_01164 HuMAP2_01512 HuMAP2_01841 HuMAP2_02949 HuMAP2_05004
GAR1	HuMAP2_00041 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_03262
LIN28B	HuMAP2_00041 HuMAP2_01512 HuMAP2_02949
POP1	HuMAP2_00041 HuMAP2_01164 HuMAP2_01338 HuMAP2_01512
DKC1	HuMAP2_00041 HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_02076 HuMAP2_03262 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
ZBTB11	HuMAP2_00041 HuMAP2_01841 HuMAP2_02349
ZCCHC9	HuMAP2_00041 HuMAP2_01223
CTCF	HuMAP2_00041 HuMAP2_01164 HuMAP2_01512 HuMAP2_01841 HuMAP2_05004
HP1BP3	HuMAP2_00041 HuMAP2_00537 HuMAP2_00574 HuMAP2_01164 HuMAP2_01512 HuMAP2_05004 HuMAP2_05439 HuMAP2_06347
C8orf33	HuMAP2_00041 HuMAP2_01841 HuMAP2_02949
ZCRB1	HuMAP2_00041 HuMAP2_01841 HuMAP2_02349 HuMAP2_02949

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00041