hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00070

Confidence: Medium High

Genename	Protein Name	Links
CHD8	Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)	UniProt NCBI
CDC73	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	UniProt NCBI
ELOA	Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3)	UniProt NCBI
CTR9	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)	UniProt NCBI
LEO1	RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)	UniProt NCBI
PAF1	RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)	UniProt NCBI
WDR61	WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) (SKI8 homolog) (Ski8) [Cleaved into: WD repeat-containing protein 61, N-terminally processed]	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1167	1.83011155706e-16	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	Paf complex
REAC:R-HSA-75955	3.47166909111e-12	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	3.47166909111e-12	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	Formation of RNA Pol II elongation complex
GO:0016593	9.63047224659e-12	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	Cdc73/Paf1 complex
REAC:R-HSA-674695	2.69440600988e-11	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	RNA Polymerase II Pre-transcription Events
GO:0032968	1.0630951546e-09	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	positive regulation of transcription elongation from RNA polymerase II promoter
REAC:R-HSA-8866654	2.18521316311e-09	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	E3 ubiquitin ligases ubiquitinate target proteins
GO:0006368	6.39627721266e-09	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	transcription elongation from RNA polymerase II promoter
REAC:R-HSA-8852135	9.85258187913e-09	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	Protein ubiquitination
GO:0034243	1.38538402516e-08	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	regulation of transcription elongation from RNA polymerase II promoter
GO:0032786	2.03746319849e-08	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	positive regulation of DNA-templated transcription, elongation
GO:0006354	3.69773994922e-08	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	DNA-templated transcription, elongation
GO:0001711	1.07497741607e-07	0.571428571429	CDC73 LEO1 CTR9 PAF1	endodermal cell fate commitment
GO:0032784	2.34730462463e-07	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	regulation of DNA-templated transcription, elongation
GO:0045638	3.26428463825e-07	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	negative regulation of myeloid cell differentiation
GO:0008023	3.62657595534e-07	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	transcription elongation factor complex
GO:0033523	4.22108321339e-07	0.571428571429	CDC73 LEO1 CTR9 PAF1	histone H2B ubiquitination
GO:0060795	1.55099339163e-06	0.571428571429	CDC73 LEO1 CTR9 PAF1	cell fate commitment involved in formation of primary germ layer
GO:0016591	2.38895426042e-06	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	RNA polymerase II, holoenzyme
GO:1903707	4.65353973942e-06	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	negative regulation of hemopoiesis
WP:WP2853	8.35769132145e-06	0.571428571429	CDC73 LEO1 CTR9 PAF1	Endoderm Differentiation
GO:0055029	1.04083669472e-05	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	nuclear DNA-directed RNA polymerase complex
GO:0000428	1.09728045288e-05	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	DNA-directed RNA polymerase complex
GO:0031440	1.27197659979e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	regulation of mRNA 3'-end processing
GO:0030880	1.28143892542e-05	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	RNA polymerase complex
GO:0010390	2.01980560179e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	histone monoubiquitination
GO:0035987	5.00367523263e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	endodermal cell differentiation
GO:0000993	5.60927563414e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	RNA polymerase II complex binding
GO:0001706	6.26817828938e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	endoderm formation
GO:0006378	7.75809589829e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	mRNA polyadenylation
GO:0043631	9.49866794351e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	RNA polyadenylation
GO:0007492	9.49866794351e-05	0.571428571429	CDC73 LEO1 CTR9 PAF1	endoderm development
GO:0016574	0.00010471199091	0.571428571429	CDC73 LEO1 CTR9 PAF1	histone ubiquitination
GO:0043175	0.00010471199091	0.571428571429	CDC73 LEO1 CTR9 PAF1	RNA polymerase core enzyme binding
GO:0045637	0.000110659672894	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	regulation of myeloid cell differentiation
GO:0001098	0.000229373391109	0.571428571429	CDC73 LEO1 CTR9 PAF1	basal transcription machinery binding
GO:0001099	0.000229373391109	0.571428571429	CDC73 LEO1 CTR9 PAF1	basal RNA polymerase II transcription machinery binding
REAC:R-HSA-73857	0.00023249479605	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	RNA Polymerase II Transcription
GO:0070063	0.000334404312038	0.571428571429	CDC73 LEO1 CTR9 PAF1	RNA polymerase binding
GO:0031442	0.000380900357231	0.428571428571	CDC73 LEO1 PAF1	positive regulation of mRNA 3'-end processing
GO:0006513	0.000385172296353	0.571428571429	CDC73 LEO1 CTR9 PAF1	protein monoubiquitination
GO:0001704	0.000441502177302	0.571428571429	CDC73 LEO1 CTR9 PAF1	formation of primary germ layer
REAC:R-HSA-74160	0.000444522787502	0.857142857143	CTR9 CDC73 LEO1 PAF1 WDR61 ELOA	Gene expression (Transcription)
GO:0061695	0.000737359830084	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	transferase complex, transferring phosphorus-containing groups
GO:0030099	0.000899327340958	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	myeloid cell differentiation
GO:0006325	0.00117516939098	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	chromatin organization
GO:0002683	0.00123133225428	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	negative regulation of immune system process
GO:0007369	0.00187525903549	0.571428571429	CDC73 LEO1 CTR9 PAF1	gastrulation
GO:0031124	0.00245741336962	0.571428571429	CDC73 LEO1 CTR9 PAF1	mRNA 3'-end processing
GO:0006357	0.00307195999035	1.0	CHD8 CDC73 LEO1 PAF1 WDR61 ELOA CTR9	regulation of transcription by RNA polymerase II
GO:1903706	0.00315136554861	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	regulation of hemopoiesis
GO:1990234	0.00351782066073	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	transferase complex
GO:0016570	0.00486095881307	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	histone modification
GO:0035327	0.00487641079113	0.428571428571	WDR61 PAF1 CTR9	transcriptionally active chromatin
GO:0045165	0.0057979568963	0.571428571429	CDC73 LEO1 CTR9 PAF1	cell fate commitment
GO:0016569	0.00608908705118	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	covalent chromatin modification
GO:0006366	0.0065302926108	1.0	CHD8 CDC73 LEO1 PAF1 WDR61 ELOA CTR9	transcription by RNA polymerase II
GO:0045944	0.006878256027	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	positive regulation of transcription by RNA polymerase II
GO:0050684	0.00711785297927	0.571428571429	CDC73 LEO1 CTR9 PAF1	regulation of mRNA processing
GO:0050685	0.00727854676446	0.428571428571	CDC73 LEO1 PAF1	positive regulation of mRNA processing
GO:0045596	0.00809832088077	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	negative regulation of cell differentiation
GO:2001160	0.00946729163895	0.285714285714	WDR61 CTR9	regulation of histone H3-K79 methylation
GO:2001162	0.00946729163895	0.285714285714	WDR61 CTR9	positive regulation of histone H3-K79 methylation
GO:0031123	0.0107359250842	0.571428571429	CDC73 LEO1 CTR9 PAF1	RNA 3'-end processing
GO:0031062	0.0128352677703	0.428571428571	WDR61 PAF1 CTR9	positive regulation of histone methylation
REAC:R-HSA-597592	0.0130103492531	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	Post-translational protein modification
GO:0044451	0.0180209467821	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	nucleoplasm part
REAC:R-HSA-201681	0.0182953414124	0.428571428571	CDC73 LEO1 CHD8	TCF dependent signaling in response to WNT
GO:0051276	0.0190987011465	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	chromosome organization
GO:0034729	0.0283955176165	0.285714285714	WDR61 CTR9	histone H3-K79 methylation
GO:0030097	0.0353227467398	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	hemopoiesis
GO:0031060	0.0389125948999	0.428571428571	WDR61 PAF1 CTR9	regulation of histone methylation
GO:0048534	0.0398891965867	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	hematopoietic or lymphoid organ development
GO:0051093	0.0419250581215	0.714285714286	CDC73 CTR9 LEO1 WDR61 PAF1	negative regulation of developmental process
CORUM:0000000	0.0437772681198	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	CORUM root
GO:0045893	0.0445849091293	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	positive regulation of transcription, DNA-templated
GO:1903508	0.0453336533471	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	positive regulation of nucleic acid-templated transcription
GO:1902680	0.0455855403627	0.857142857143	CTR9 CDC73 PAF1 WDR61 LEO1 CHD8	positive regulation of RNA biosynthetic process
REAC:R-HSA-195721	0.0491203268289	0.428571428571	CDC73 LEO1 CHD8	Signaling by WNT

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PAF1	CTR9	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9) Malo fraction boldt_WMM
PAF1	CDC73	1.0	0.949	hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73) Malo fraction boldt_WMM
LEO1	CDC73	1.0	0.949	hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,LEO1) Malo fraction boldt_WMM
CDC73	WDR61	1.0	0.949	hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,WDR61) Malo fraction boldt_WMM
CDC73	CTR9	1.0	0.949	hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,CTR9) Malo fraction boldt_WMM
LEO1	CTR9	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9,LEO1) Malo fraction boldt_WMM
PAF1	WDR61	0.999	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (WDR61) Malo fraction boldt_WMM
LEO1	PAF1	0.998	0.945	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LEO1) Malo fraction boldt_WMM
LEO1	WDR61	0.997	0.929	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LEO1,WDR61) Malo fraction boldt_WMM
WDR61	CTR9	0.988	0.901	hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9) Malo fraction boldt_WMM
CHD8	PAF1	0.129	0.399	bioplex_WMM Guru youn_WMM fraction
ELOA	CTR9	0.1	0.362	hein_WMM boldt youn_WMM hein (CTR9) boldt_WMM
CHD8	CDC73	0.05	0.295	bioplex_WMM Guru youn_WMM gupta_WMM fraction
LEO1	ELOA	0.041	0.271	hein_WMM boldt youn_WMM hein (LEO1) boldt_WMM
CHD8	CTR9	0.014	0.14	bioplex_WMM Guru youn_WMM fraction
CDC73	ELOA	0.01	0.097	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
PAF1	ELOA	0.009	0.098	hein_WMM boldt youn_WMM boldt_WMM
WDR61	ELOA	0.008	0.084	hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM
CHD8	ELOA	0.007	0.004	youn_WMM gupta_WMM WMM_only
CHD8	WDR61	0.0	0.01	Guru youn_WMM fraction
LEO1	CHD8	0.0	0.003	Guru youn_WMM fraction

Images

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Complex HuMAP2_00070 has an average edge precision of 0.532 which is ranked 2320 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CHD8	HuMAP2_00070 HuMAP2_01456
CDC73	HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117
ELOA	HuMAP2_00070 HuMAP2_02419 HuMAP2_04183 HuMAP2_05769
CTR9	HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_06434
LEO1	HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117
PAF1	HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_06434
WDR61	HuMAP2_00070 HuMAP2_01728 HuMAP2_02419

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00070