hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00073
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS35 | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | UniProt NCBI |
| SNX2 | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | UniProt NCBI |
| ANKRD27 | Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) | UniProt NCBI |
| VPS26A | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | UniProt NCBI |
| TBC1D5 | TBC1 domain family member 5 | UniProt NCBI |
| SNX32 | Sorting nexin-32 (Sorting nexin-6B) | UniProt NCBI |
| VPS26B | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | UniProt NCBI |
| SNX1 | Sorting nexin-1 | UniProt NCBI |
| SNX6 | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | UniProt NCBI |
| SNX5 | Sorting nexin-5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030904 | 1.64046688979e-18 | 0.8 | SNX1 SNX5 SNX2 SNX6 VPS26B VPS35 VPS26A TBC1D5 | retromer complex |
| GO:0016482 | 2.41953775638e-16 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | cytosolic transport |
| GO:0042147 | 1.30990520977e-15 | 0.9 | SNX1 SNX32 SNX2 SNX6 VPS26B VPS35 VPS26A SNX5 TBC1D5 | retrograde transport, endosome to Golgi |
| GO:0016197 | 7.60620017061e-15 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | endosomal transport |
| GO:0097422 | 2.06436583637e-12 | 0.5 | VPS26A VPS35 ANKRD27 SNX5 SNX6 | tubular endosome |
| KEGG:04144 | 6.25038461692e-12 | 0.8 | SNX1 SNX32 SNX2 SNX6 VPS26B VPS35 VPS26A SNX5 | Endocytosis |
| CORUM:657 | 3.81057767206e-11 | 0.4 | VPS26A VPS35 SNX2 SNX1 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1060 | 3.81057767206e-11 | 0.4 | VPS35 VPS26B SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| CORUM:1059 | 3.81057767206e-11 | 0.4 | VPS26A VPS35 SNX2 SNX1 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| GO:0005768 | 6.08251194599e-10 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | endosome |
| GO:0030905 | 5.12306788392e-09 | 0.4 | SNX5 SNX1 SNX2 SNX6 | retromer, tubulation complex |
| GO:0044440 | 7.74979322964e-08 | 0.8 | SNX1 TBC1D5 SNX5 SNX6 SNX2 VPS35 VPS26A ANKRD27 | endosomal part |
| GO:0005769 | 6.63098536985e-07 | 0.7 | SNX1 SNX5 SNX6 VPS26B VPS35 VPS26A ANKRD27 | early endosome |
| GO:0016236 | 2.34545639463e-06 | 0.7 | SNX32 VPS26B SNX6 VPS35 VPS26A SNX5 TBC1D5 | macroautophagy |
| GO:0046907 | 3.14505843375e-06 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | intracellular transport |
| GO:0010008 | 3.88062842301e-06 | 0.7 | SNX1 SNX5 SNX6 SNX2 VPS35 VPS26A TBC1D5 | endosome membrane |
| GO:0016192 | 7.11890409182e-06 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | vesicle-mediated transport |
| GO:0016241 | 7.48260226063e-06 | 0.6 | SNX32 VPS26B SNX6 VPS35 VPS26A SNX5 | regulation of macroautophagy |
| GO:0031410 | 7.49685650446e-06 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | cytoplasmic vesicle |
| GO:0097708 | 7.54534846115e-06 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | intracellular vesicle |
| GO:0051649 | 2.4935578664e-05 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | establishment of localization in cell |
| CORUM:1058 | 3.01890677263e-05 | 0.2 | SNX1 SNX6 | SNX complex (SNX1, SNX6) |
| GO:0030906 | 4.35775472874e-05 | 0.3 | VPS35 VPS26B VPS26A | retromer, cargo-selective complex |
| GO:0061919 | 4.9045609427e-05 | 0.7 | SNX32 VPS26B SNX6 VPS35 VPS26A SNX5 TBC1D5 | process utilizing autophagic mechanism |
| GO:0006914 | 4.9045609427e-05 | 0.7 | SNX32 VPS26B SNX6 VPS35 VPS26A SNX5 TBC1D5 | autophagy |
| CORUM:656 | 9.0534767973e-05 | 0.2 | VPS35 VPS26A | VPS35-VPS29-VPS26A complex |
| CORUM:1070 | 9.0534767973e-05 | 0.2 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4) |
| CORUM:1091 | 0.000181004688405 | 0.2 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, LEPR) |
| CORUM:1093 | 0.000181004688405 | 0.2 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, INSR) |
| CORUM:1096 | 0.000181004688405 | 0.2 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, PDGFRA) |
| CORUM:1095 | 0.000181004688405 | 0.2 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, EGFR) |
| GO:0098796 | 0.000256626613347 | 0.8 | SNX1 SNX5 SNX2 SNX6 VPS26B VPS35 VPS26A TBC1D5 | membrane protein complex |
| GO:0010506 | 0.000283441415229 | 0.6 | SNX32 VPS26B SNX6 VPS35 VPS26A SNX5 | regulation of autophagy |
| GO:0051641 | 0.000382578668236 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | cellular localization |
| GO:0005773 | 0.00058486824452 | 0.7 | SNX1 TBC1D5 SNX6 SNX2 VPS35 VPS26A ANKRD27 | vacuole |
| GO:0044433 | 0.00110870749592 | 0.8 | SNX1 TBC1D5 SNX5 SNX6 SNX2 VPS35 VPS26A ANKRD27 | cytoplasmic vesicle part |
| GO:0031982 | 0.0051648556644 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | vesicle |
| GO:0012505 | 0.00946154548006 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | endomembrane system |
| GO:0005764 | 0.0133189478403 | 0.6 | SNX1 SNX6 SNX2 VPS35 VPS26A ANKRD27 | lysosome |
| GO:0000323 | 0.0133189478403 | 0.6 | SNX1 SNX6 SNX2 VPS35 VPS26A ANKRD27 | lytic vacuole |
| REAC:R-HSA-3238698 | 0.0213144720828 | 0.2 | VPS35 VPS26A | WNT ligand biogenesis and trafficking |
| GO:1990126 | 0.0248721634083 | 0.3 | VPS35 ANKRD27 VPS26A | retrograde transport, endosome to plasma membrane |
| GO:0006810 | 0.0335230904593 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | transport |
| GO:0051234 | 0.0449543498994 | 1.0 | SNX1 TBC1D5 SNX32 SNX2 SNX6 VPS26B VPS35 ANKRD27 SNX5 VPS26A | establishment of localization |
| CORUM:1072 | 0.0499561984052 | 0.1 | SNX2 | SNX complex (SNX2), oligomeric |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS35 | VPS26A | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM hein (VPS26A) gupta_WMM |
| VPS26B | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM hein (VPS26B) |
| VPS26B | VPS35 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM Guru boldt hein (VPS26B) fraction boldt_WMM |
| SNX2 | VPS26A | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SNX2 | SNX6 | 0.993 | 0.918 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SNX2 | SNX5 | 0.99 | 0.909 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SNX1 | VPS26B | 0.988 | 0.901 | fraction |
| VPS26B | SNX2 | 0.988 | 0.901 | fraction |
| SNX1 | VPS35 | 0.988 | 0.901 | youn_WMM gupta_WMM fraction |
| SNX2 | VPS35 | 0.988 | 0.902 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SNX1 | VPS26A | 0.952 | 0.858 | youn_WMM gupta_WMM fraction |
| SNX1 | SNX6 | 0.951 | 0.858 | bioplex (SNX1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| VPS26B | VPS26A | 0.888 | 0.818 | bioplex (VPS26A,VPS26B) bioplex_WMM fraction |
| SNX32 | SNX1 | 0.582 | 0.664 | bioplex (SNX1,SNX32) bioplex_WMM |
| SNX1 | SNX5 | 0.567 | 0.654 | bioplex (SNX1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| VPS26A | SNX5 | 0.288 | 0.489 | bioplex_WMM fraction |
| SNX1 | SNX2 | 0.273 | 0.485 | bioplex (SNX1) bioplex_WMM youn_WMM gupta_WMM |
| ANKRD27 | VPS26A | 0.207 | 0.455 | hein_WMM bioplex_WMM hein (VPS26A) |
| VPS26B | ANKRD27 | 0.144 | 0.406 | hein_WMM bioplex_WMM hein (VPS26B) |
| SNX32 | SNX6 | 0.065 | 0.346 | bioplex (SNX32) bioplex_WMM |
| SNX6 | VPS26A | 0.056 | 0.313 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| VPS26B | SNX6 | 0.025 | 0.218 | fraction |
| VPS35 | TBC1D5 | 0.019 | 0.182 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| VPS35 | SNX6 | 0.017 | 0.176 | bioplex_WMM gupta_WMM fraction |
| ANKRD27 | TBC1D5 | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| VPS35 | ANKRD27 | 0.01 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| SNX32 | SNX5 | 0.008 | 0.05 | bioplex_WMM WMM_only |
| SNX6 | SNX5 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| SNX6 | TBC1D5 | 0.007 | 0.001 | youn_WMM gupta_WMM WMM_only |
| VPS35 | SNX5 | 0.006 | 0.008 | bioplex_WMM gupta_WMM fraction |
| SNX32 | SNX2 | 0.005 | 0.011 | bioplex (SNX32) bioplex_WMM |
| SNX1 | TBC1D5 | 0.0 | 0.018 | youn_WMM gupta_WMM fraction |
| VPS26B | SNX5 | 0.0 | 0.013 | fraction |
| SNX2 | TBC1D5 | 0.0 | 0.012 | youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_00073 has an average edge precision of 0.5 which is ranked 2496 out of all 6965 complexes.
Related Complexes