hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00077
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| REEP2 | Receptor expression-enhancing protein 2 | UniProt NCBI |
| REEP1 | Receptor expression-enhancing protein 1 (Spastic paraplegia 31 protein) | UniProt NCBI |
| SPRY2 | Protein sprouty homolog 2 (Spry-2) | UniProt NCBI |
| PLSCR1 | Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (MmTRA1b) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP437 | 0.0210695886397 | 0.5 | SPRY2 PLSCR1 | EGF/EGFR Signaling Pathway |
| HP:0002064 | 0.0335949626331 | 0.5 | REEP1 REEP2 | Spastic gait |
| REAC:R-HSA-381753 | 0.0454682616856 | 0.5 | REEP1 REEP2 | Olfactory Signaling Pathway |
| HP:0002495 | 0.0455708870915 | 0.5 | REEP1 REEP2 | Impaired vibratory sensation |
| CORUM:6430 | 0.0499140284799 | 0.25 | REEP1 | ATL2-SPG31 complex |
| CORUM:6431 | 0.0499140284799 | 0.25 | REEP1 | ATL3-SPG31 complex |
| CORUM:6534 | 0.0499140284799 | 0.25 | REEP1 | SPG31-SPG33 omplex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| REEP2 | REEP1 | 0.132 | 0.404 | bioplex (REEP1) bioplex_WMM |
| PLSCR1 | REEP1 | 0.023 | 0.206 | bioplex (REEP1) bioplex_WMM |
| SPRY2 | PLSCR1 | 0.021 | 0.185 | bioplex (SPRY2) bioplex_WMM |
| SPRY2 | REEP2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SPRY2 | REEP1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| REEP2 | PLSCR1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00077 has an average edge precision of 0.155 which is ranked 6670 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| REEP2 | HuMAP2_00077 HuMAP2_00271 HuMAP2_03171 HuMAP2_06254 |
| REEP1 | HuMAP2_00077 HuMAP2_03171 HuMAP2_06254 |
| SPRY2 | HuMAP2_00077 HuMAP2_00271 HuMAP2_02998 HuMAP2_03171 HuMAP2_04240 |
| PLSCR1 | HuMAP2_00077 HuMAP2_02998 HuMAP2_03171 HuMAP2_03415 HuMAP2_04240 HuMAP2_05251 |