hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00081
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IFT52 | Intraflagellar transport protein 52 homolog (Protein NGD5 homolog) | UniProt NCBI |
| IFT74 | Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) | UniProt NCBI |
| IFT27 | Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4) | UniProt NCBI |
| IFT46 | Intraflagellar transport protein 46 homolog | UniProt NCBI |
| TTC26 | Intraflagellar transport protein 56 (Tetratricopeptide repeat protein 26) (TPR repeat protein 26) | UniProt NCBI |
| IFT81 | Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) | UniProt NCBI |
| TTC30A | Tetratricopeptide repeat protein 30A (TPR repeat protein 30A) | UniProt NCBI |
| TTC30B | Tetratricopeptide repeat protein 30B (TPR repeat protein 30B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6173 | 1.37944508201e-21 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | Intraflagellar transport complex B core complex |
| GO:0030992 | 2.02768869699e-20 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | intraciliary transport particle B |
| CORUM:6172 | 7.39509995372e-20 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | Intraflagellar transport complex B |
| GO:0030990 | 9.0213796892e-19 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | intraciliary transport particle |
| REAC:R-HSA-5620924 | 1.88341084739e-18 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | Intraflagellar transport |
| GO:0042073 | 4.47808626186e-16 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | intraciliary transport |
| GO:0099118 | 2.13413680267e-15 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | microtubule-based protein transport |
| GO:0098840 | 2.13413680267e-15 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | protein transport along microtubule |
| WP:WP4352 | 7.47442024769e-14 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | Ciliary landscape |
| REAC:R-HSA-5617833 | 1.1199468523e-13 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | Cilium Assembly |
| GO:0035735 | 2.31051702993e-13 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | intraciliary transport involved in cilium assembly |
| WP:WP4536 | 2.47611239596e-13 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | Genes related to primary cilium development (based on CRISPR) |
| GO:0097542 | 4.7479917077e-13 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | ciliary tip |
| GO:0010970 | 1.27135367948e-12 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | transport along microtubule |
| REAC:R-HSA-1852241 | 2.43388104095e-12 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | Organelle biogenesis and maintenance |
| GO:0099111 | 3.1379373903e-12 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | microtubule-based transport |
| GO:0030705 | 4.8875787604e-12 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cytoskeleton-dependent intracellular transport |
| GO:0031503 | 1.38257531197e-10 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | protein-containing complex localization |
| GO:0007018 | 1.53677661252e-10 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | microtubule-based movement |
| GO:0044441 | 2.60625951341e-09 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | ciliary part |
| GO:0044782 | 3.16504945902e-09 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cilium organization |
| GO:0005929 | 1.4248415749e-08 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cilium |
| GO:0007017 | 4.66430679326e-07 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | microtubule-based process |
| GO:0060271 | 7.77827354513e-07 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | cilium assembly |
| GO:0044463 | 2.6782552847e-06 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cell projection part |
| GO:0120038 | 2.6782552847e-06 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | plasma membrane bounded cell projection part |
| GO:0120170 | 5.08584025729e-06 | 0.375 | TTC26 TTC30A TTC30B | intraciliary transport particle B binding |
| GO:0120031 | 8.16326008913e-06 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | plasma membrane bounded cell projection assembly |
| GO:0030031 | 9.38935094752e-06 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | cell projection assembly |
| GO:0006886 | 1.02082595948e-05 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | intracellular protein transport |
| WP:WP4532 | 1.49659866864e-05 | 0.375 | IFT81 IFT27 IFT46 | Intraflagellar transport proteins binding to dynein |
| GO:0120036 | 2.17869797112e-05 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | plasma membrane bounded cell projection organization |
| GO:0030030 | 2.37663414302e-05 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cell projection organization |
| GO:0031514 | 3.06700561997e-05 | 0.625 | IFT46 IFT81 IFT74 IFT52 IFT27 | motile cilium |
| GO:0036064 | 3.75909855022e-05 | 0.625 | IFT46 TTC26 IFT81 TTC30A TTC30B | ciliary basal body |
| GO:0120025 | 6.21885492191e-05 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | plasma membrane bounded cell projection |
| GO:0005815 | 6.27827537999e-05 | 0.875 | IFT81 TTC26 TTC30A TTC30B IFT52 IFT46 IFT74 | microtubule organizing center |
| GO:0042995 | 6.66587228296e-05 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cell projection |
| GO:0070925 | 0.000149537629199 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | organelle assembly |
| GO:0015031 | 0.000190092821208 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | protein transport |
| GO:0015833 | 0.000213126626925 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | peptide transport |
| GO:0042886 | 0.00023576916729 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | amide transport |
| GO:0006928 | 0.000284154798906 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | movement of cell or subcellular component |
| GO:0046907 | 0.000346824278428 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | intracellular transport |
| GO:0045184 | 0.000350744550473 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | establishment of protein localization |
| GO:0034613 | 0.000551760175722 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cellular protein localization |
| GO:0070727 | 0.00057867024204 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cellular macromolecule localization |
| GO:0071705 | 0.000652723871129 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | nitrogen compound transport |
| GO:0015630 | 0.00140172168705 | 0.875 | IFT81 TTC26 TTC30A TTC30B IFT52 IFT46 IFT74 | microtubule cytoskeleton |
| HP:0010442 | 0.00142119754348 | 0.5 | IFT81 IFT74 IFT52 IFT27 | Polydactyly |
| GO:0051649 | 0.00181553402649 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | establishment of localization in cell |
| GO:0071702 | 0.00216573094845 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | organic substance transport |
| GO:0008104 | 0.00449630294969 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | protein localization |
| GO:0044430 | 0.0075667656243 | 0.875 | IFT81 TTC26 TTC30A TTC30B IFT52 IFT46 IFT74 | cytoskeletal part |
| CORUM:0000000 | 0.00993810898821 | 0.875 | IFT81 TTC26 IFT52 TTC30B IFT27 IFT46 IFT74 | CORUM root |
| GO:0033036 | 0.0104943221162 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | macromolecule localization |
| WP:000000 | 0.0134045376724 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | WIKIPATHWAYS |
| GO:0051641 | 0.0161157357033 | 1.0 | IFT74 TTC26 IFT52 TTC30A TTC30B IFT27 IFT46 IFT81 | cellular localization |
| HP:0100259 | 0.0164843866644 | 0.375 | IFT27 IFT52 IFT81 | Postaxial polydactyly |
| GO:0005856 | 0.0335519954693 | 0.875 | IFT81 TTC26 TTC30A TTC30B IFT52 IFT46 IFT74 | cytoskeleton |
| GO:0035720 | 0.0378589948753 | 0.25 | TTC26 IFT52 | intraciliary anterograde transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IFT74 | IFT81 | 1.0 | 0.949 | bioplex (IFT74,IFT81) bioplex_WMM boldt (IFT74,IFT81) youn_WMM gupta_WMM fraction boldt_WMM |
| IFT74 | TTC30A | 0.99 | 0.907 | bioplex (TTC30A) bioplex_WMM boldt (IFT74,TTC30A) boldt_WMM |
| TTC30A | IFT81 | 0.988 | 0.902 | bioplex (TTC30A) bioplex_WMM boldt (TTC30A) boldt_WMM |
| TTC30A | IFT46 | 0.987 | 0.901 | bioplex (TTC30A) bioplex_WMM boldt (IFT46,TTC30A) boldt_WMM |
| TTC30A | IFT52 | 0.984 | 0.899 | bioplex (TTC30A) bioplex_WMM boldt (TTC30A) boldt_WMM |
| TTC30B | IFT52 | 0.816 | 0.773 | bioplex (TTC30B) bioplex_WMM boldt (TTC30B) boldt_WMM |
| TTC30B | IFT81 | 0.755 | 0.748 | bioplex (TTC30B) bioplex_WMM boldt (TTC30B) boldt_WMM |
| IFT74 | IFT52 | 0.706 | 0.727 | bioplex (IFT74) bioplex_WMM boldt (IFT52,IFT74) youn_WMM boldt_WMM |
| IFT74 | IFT46 | 0.702 | 0.723 | bioplex (IFT74) bioplex_WMM boldt (IFT46,IFT74) youn_WMM gupta_WMM boldt_WMM |
| TTC26 | TTC30A | 0.688 | 0.713 | bioplex (TTC30A) bioplex_WMM boldt (TTC26,TTC30A) boldt_WMM |
| IFT27 | TTC30A | 0.613 | 0.674 | bioplex (TTC30A) bioplex_WMM boldt (IFT27,TTC30A) boldt_WMM |
| TTC30B | IFT46 | 0.543 | 0.644 | bioplex (TTC30B) bioplex_WMM boldt (IFT46) gupta_WMM boldt_WMM |
| TTC26 | TTC30B | 0.292 | 0.494 | bioplex (TTC30B) bioplex_WMM boldt (TTC30B) boldt_WMM |
| IFT27 | IFT81 | 0.178 | 0.437 | bioplex (IFT81) bioplex_WMM boldt (IFT27) youn_WMM boldt_WMM |
| IFT46 | IFT81 | 0.173 | 0.433 | bioplex (IFT81) bioplex_WMM boldt (IFT46) gupta_WMM boldt_WMM |
| IFT74 | TTC30B | 0.165 | 0.42 | bioplex (TTC30B) bioplex_WMM boldt (IFT74,TTC30B) fraction boldt_WMM |
| IFT46 | IFT52 | 0.113 | 0.382 | bioplex_WMM boldt (IFT46,IFT52) boldt_WMM |
| IFT27 | TTC30B | 0.077 | 0.354 | bioplex (TTC30B) bioplex_WMM boldt (TTC30B) boldt_WMM |
| TTC26 | IFT81 | 0.074 | 0.357 | bioplex (IFT81) bioplex_WMM boldt (IFT81,TTC26) gupta_WMM boldt_WMM |
| IFT27 | IFT46 | 0.067 | 0.351 | bioplex_WMM boldt (IFT27,IFT46) boldt_WMM |
| IFT74 | IFT27 | 0.066 | 0.346 | bioplex (IFT74) bioplex_WMM boldt (IFT27,IFT74) youn_WMM gupta_WMM fraction boldt_WMM |
| IFT81 | IFT52 | 0.05 | 0.298 | bioplex_WMM boldt (IFT52) youn_WMM boldt_WMM |
| TTC26 | IFT46 | 0.047 | 0.293 | bioplex_WMM boldt (IFT46,TTC26) boldt_WMM |
| TTC26 | IFT27 | 0.043 | 0.269 | bioplex_WMM boldt (IFT27,TTC26) boldt_WMM |
| IFT27 | IFT52 | 0.037 | 0.264 | bioplex_WMM boldt (IFT52) youn_WMM boldt_WMM |
| TTC26 | IFT74 | 0.033 | 0.252 | bioplex (IFT74) bioplex_WMM boldt (IFT74,TTC26) youn_WMM gupta_WMM fraction boldt_WMM |
| TTC30A | TTC30B | 0.013 | 0.144 | bioplex_WMM boldt (TTC30A) boldt_WMM |
| TTC26 | IFT52 | 0.0 | 0.008 | bioplex_WMM boldt (IFT52,TTC26) fraction boldt_WMM |
Images
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Complex HuMAP2_00081 has an average edge precision of 0.524 which is ranked 2378 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IFT52 | HuMAP2_00081 HuMAP2_04688 |
| IFT74 | HuMAP2_00081 HuMAP2_02738 HuMAP2_04688 |
| IFT27 | HuMAP2_00081 HuMAP2_04688 |
| IFT46 | HuMAP2_00081 HuMAP2_02738 HuMAP2_04688 |
| TTC26 | HuMAP2_00081 HuMAP2_04688 |
| IFT81 | HuMAP2_00081 HuMAP2_04688 |
| TTC30A | HuMAP2_00081 HuMAP2_02738 HuMAP2_04688 |
| TTC30B | HuMAP2_00081 HuMAP2_04688 |