hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00083
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RMI2 | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | UniProt NCBI |
| TOP3A | DNA topoisomerase 3-alpha (EC 5.6.2.2) (DNA topoisomerase III alpha) | UniProt NCBI |
| RMI1 | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | UniProt NCBI |
| CCDC69 | Coiled-coil domain-containing protein 69 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5693554 | 3.50713401381e-06 | 0.75 | TOP3A RMI2 RMI1 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| KEGG:03460 | 4.94626613091e-06 | 0.75 | TOP3A RMI2 RMI1 | Fanconi anemia pathway |
| REAC:R-HSA-5693568 | 6.68850838342e-06 | 0.75 | TOP3A RMI2 RMI1 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 7.35698811902e-06 | 0.75 | TOP3A RMI2 RMI1 | Resolution of D-Loop Structures |
| REAC:R-HSA-5685938 | 9.62627312117e-06 | 0.75 | TOP3A RMI2 RMI1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 1.13724154433e-05 | 0.75 | TOP3A RMI2 RMI1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 1.436837348e-05 | 0.75 | TOP3A RMI2 RMI1 | Homologous DNA Pairing and Strand Exchange |
| CORUM:246 | 3.01612206104e-05 | 0.5 | TOP3A RMI1 | BLM complex III |
| REAC:R-HSA-5685942 | 5.88039824914e-05 | 0.75 | TOP3A RMI2 RMI1 | HDR through Homologous Recombination (HRR) |
| CORUM:2738 | 7.53895486054e-05 | 0.5 | TOP3A RMI1 | BLM complex II |
| CORUM:2222 | 7.53895486054e-05 | 0.5 | TOP3A RMI1 | BLM complex II |
| REAC:R-HSA-6804756 | 0.000163333735977 | 0.75 | TOP3A RMI2 RMI1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 0.000180191665247 | 0.75 | TOP3A RMI2 RMI1 | G2/M DNA damage checkpoint |
| CORUM:2739 | 0.000180886312261 | 0.5 | TOP3A RMI1 | FA complex (Fanconi anemia complex) |
| REAC:R-HSA-5693607 | 0.000198169454442 | 0.75 | TOP3A RMI2 RMI1 | Processing of DNA double-strand break ends |
| CORUM:244 | 0.000276304589937 | 0.5 | TOP3A RMI1 | BRAFT complex |
| REAC:R-HSA-5693567 | 0.000480050915503 | 0.75 | TOP3A RMI2 RMI1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000550034129522 | 0.75 | TOP3A RMI2 RMI1 | Homology Directed Repair |
| REAC:R-HSA-5633007 | 0.000847823442334 | 0.75 | TOP3A RMI2 RMI1 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.000966811034897 | 0.75 | TOP3A RMI2 RMI1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.001021027578 | 0.75 | TOP3A RMI2 RMI1 | G2/M Checkpoints |
| WP:WP4016 | 0.00501103584449 | 0.5 | TOP3A RMI1 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-69620 | 0.00518999523011 | 0.75 | TOP3A RMI2 RMI1 | Cell Cycle Checkpoints |
| REAC:R-HSA-73894 | 0.00725712676591 | 0.75 | TOP3A RMI2 RMI1 | DNA Repair |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | TOP3A RMI2 RMI1 | Transcriptional Regulation by TP53 |
| CORUM:2223 | 0.0499140284799 | 0.25 | TOP3A | BLM-TOP3A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RMI2 | RMI1 | 1.0 | 0.949 | bioplex (RMI2) bioplex_WMM |
| RMI2 | TOP3A | 0.952 | 0.858 | bioplex (RMI2) bioplex_WMM |
| RMI1 | CCDC69 | 0.369 | 0.544 | bioplex (CCDC69) bioplex_WMM |
| RMI2 | CCDC69 | 0.192 | 0.446 | bioplex (CCDC69) bioplex_WMM |
| TOP3A | CCDC69 | 0.042 | 0.269 | bioplex (CCDC69) bioplex_WMM |
| TOP3A | RMI1 | 0.032 | 0.244 | hein_WMM bioplex (RMI1) bioplex_WMM |
Images
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Complex HuMAP2_00083 has an average edge precision of 0.552 which is ranked 2186 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RMI2 | HuMAP2_00083 HuMAP2_03260 HuMAP2_04847 HuMAP2_06528 |
| TOP3A | HuMAP2_00083 HuMAP2_04847 HuMAP2_06528 |
| RMI1 | HuMAP2_00083 HuMAP2_03260 HuMAP2_04847 HuMAP2_06528 |
| CCDC69 | HuMAP2_00083 HuMAP2_04847 |