hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00084
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | UniProt NCBI |
| PRKACA | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:520 | 1.00555407742e-05 | 1.0 | PRKACA PRKAR2A | KCNQ1 macromolecular complex |
| REAC:R-HSA-9010642 | 4.69258569465e-05 | 1.0 | PRKACA PRKAR2A | ROBO receptors bind AKAP5 |
| REAC:R-HSA-442720 | 9.21757904306e-05 | 1.0 | PRKACA PRKAR2A | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| WP:WP2012 | 0.000121088932808 | 1.0 | PRKACA PRKAR2A | miRs in Muscle Cell Differentiation |
| WP:WP3965 | 0.000140835743389 | 1.0 | PRKACA PRKAR2A | Lipid Metabolism Pathway |
| REAC:R-HSA-163615 | 0.000201110815485 | 1.0 | PRKACA PRKAR2A | PKA activation |
| REAC:R-HSA-164378 | 0.000227925590883 | 1.0 | PRKACA PRKAR2A | PKA activation in glucagon signalling |
| REAC:R-HSA-111931 | 0.000256416289743 | 1.0 | PRKACA PRKAR2A | PKA-mediated phosphorylation of CREB |
| REAC:R-HSA-180024 | 0.000424008635981 | 1.0 | PRKACA PRKAR2A | DARPP-32 events |
| REAC:R-HSA-163359 | 0.000779304410004 | 1.0 | PRKACA PRKAR2A | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-111933 | 0.000884887588134 | 1.0 | PRKACA PRKAR2A | Calmodulin induced events |
| REAC:R-HSA-111997 | 0.000884887588134 | 1.0 | PRKACA PRKAR2A | CaM pathway |
| REAC:R-HSA-111996 | 0.000997174460113 | 1.0 | PRKACA PRKAR2A | Ca-dependent events |
| REAC:R-HSA-381676 | 0.000997174460113 | 1.0 | PRKACA PRKAR2A | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-432040 | 0.00111616502594 | 1.0 | PRKACA PRKAR2A | Vasopressin regulates renal water homeostasis via Aquaporins |
| KEGG:04910 | 0.00113070596705 | 1.0 | PRKACA PRKAR2A | Insulin signaling pathway |
| REAC:R-HSA-1489509 | 0.00124185928562 | 1.0 | PRKACA PRKAR2A | DAG and IP3 signaling |
| REAC:R-HSA-445717 | 0.00124185928562 | 1.0 | PRKACA PRKAR2A | Aquaporin-mediated transport |
| WP:WP35 | 0.00139382676196 | 1.0 | PRKACA PRKAR2A | G Protein Signaling Pathways |
| WP:WP4540 | 0.00139382676196 | 1.0 | PRKACA PRKAR2A | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 0.00191916643968 | 1.0 | PRKACA PRKAR2A | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-112043 | 0.00213680241453 | 1.0 | PRKACA PRKAR2A | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.00222227451111 | 1.0 | PRKACA PRKAR2A | G-protein mediated events |
| WP:WP536 | 0.00266023070847 | 1.0 | PRKACA PRKAR2A | Calcium Regulation in the Cardiac Cell |
| WP:WP706 | 0.0030283410642 | 1.0 | PRKACA PRKAR2A | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| WP:WP289 | 0.00317253003958 | 1.0 | PRKACA PRKAR2A | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-422356 | 0.00393171644273 | 1.0 | PRKACA PRKAR2A | Regulation of insulin secretion |
| REAC:R-HSA-438064 | 0.00440432685912 | 1.0 | PRKACA PRKAR2A | Post NMDA receptor activation events |
| REAC:R-HSA-442755 | 0.00584226918984 | 1.0 | PRKACA PRKAR2A | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-111885 | 0.00612550025498 | 1.0 | PRKACA PRKAR2A | Opioid Signalling |
| REAC:R-HSA-163685 | 0.00780309964082 | 1.0 | PRKACA PRKAR2A | Integration of energy metabolism |
| GO:0005952 | 0.00946729163895 | 1.0 | PRKACA PRKAR2A | cAMP-dependent protein kinase complex |
| REAC:R-HSA-5610787 | 0.0102315127378 | 1.0 | PRKACA PRKAR2A | Hedgehog 'off' state |
| REAC:R-HSA-5358351 | 0.0167776697818 | 1.0 | PRKACA PRKAR2A | Signaling by Hedgehog |
| REAC:R-HSA-983231 | 0.0210512746109 | 1.0 | PRKACA PRKAR2A | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-112314 | 0.0255159347147 | 1.0 | PRKACA PRKAR2A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-376176 | 0.0378389999335 | 1.0 | PRKACA PRKAR2A | Signaling by ROBO receptors |
| REAC:R-HSA-112315 | 0.0429891127334 | 1.0 | PRKACA PRKAR2A | Transmission across Chemical Synapses |
| HP:0500011 | 0.0497341708567 | 0.5 | PRKACA | Moon facies |
| REAC:R-HSA-9022535 | 0.0499173803268 | 0.5 | PRKACA | Loss of phosphorylation of MECP2 at T308 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAR2A | PRKACA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (PRKAR2A) Malo gupta_WMM fraction |
Images
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Complex HuMAP2_00084 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKAR2A | HuMAP2_00084 HuMAP2_01784 HuMAP2_01832 HuMAP2_04684 |
| PRKACA | HuMAP2_00084 HuMAP2_01784 HuMAP2_01832 HuMAP2_04684 |