hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00089
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MDC1 | Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) | UniProt NCBI |
| MTA2 | Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex) | UniProt NCBI |
| HIST2H2AC | Histone H2A type 2-C (Histone H2A-GL101) (Histone H2A/q) | UniProt NCBI |
| VPS13D | Vacuolar protein sorting-associated protein 13D | UniProt NCBI |
| PRDX4 | Peroxiredoxin-4 (EC 1.11.1.15) (Antioxidant enzyme AOE372) (AOE37-2) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-427389 | 0.0370902496619 | 0.4 | HIST2H2AC MTA2 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MDC1 | MTA2 | 0.048 | 0.295 | hein_WMM youn_WMM gupta_WMM fraction |
| HIST2H2AC | MTA2 | 0.029 | 0.232 | hein_WMM hein (MTA2) |
| MTA2 | VPS13D | 0.027 | 0.231 | youn_WMM fraction |
| MTA2 | PRDX4 | 0.024 | 0.216 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MDC1 | PRDX4 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| MDC1 | VPS13D | 0.007 | 0.001 | youn_WMM WMM_only |
| PRDX4 | VPS13D | 0.007 | 0.004 | WMM_only boldt_WMM |
| HIST2H2AC | PRDX4 | 0.007 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00089 has an average edge precision of 0.123 which is ranked 6857 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MDC1 | HuMAP2_00089 HuMAP2_00974 HuMAP2_01103 HuMAP2_02945 HuMAP2_04010 HuMAP2_05156 HuMAP2_05443 HuMAP2_06754 HuMAP2_06775 |
| MTA2 | HuMAP2_00089 HuMAP2_02937 HuMAP2_03645 HuMAP2_05156 HuMAP2_06754 HuMAP2_06969 |
| HIST2H2AC | HuMAP2_00089 HuMAP2_00379 HuMAP2_01862 |
| VPS13D | HuMAP2_00089 HuMAP2_06754 |
| PRDX4 | HuMAP2_00089 |