hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00093
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSD3B1 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G) | UniProt NCBI |
| HSD3B2 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] | UniProt NCBI |
| TMEM38A | Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (Transmembrane protein 38A) | UniProt NCBI |
| MTHFR | Methylenetetrahydrofolate reductase (EC 1.5.1.20) | UniProt NCBI |
| GNAZ | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:001020_01 | 1.34173634339e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona glomerulosa[Uncertain,Low] |
| HPA:001020_11 | 1.34173634339e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona glomerulosa[Supported,Low] |
| HPA:001010_11 | 1.34173634339e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona fasciculata[Supported,Low] |
| HPA:001010_01 | 1.34173634339e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona fasciculata[Uncertain,Low] |
| REAC:R-HSA-193993 | 1.34977069275e-05 | 0.4 | HSD3B1 HSD3B2 | Mineralocorticoid biosynthesis |
| WP:WP237 | 2.00312144908e-05 | 0.4 | HSD3B1 HSD3B2 | Glucocorticoid and Mineralcorticoid Metabolism |
| HPA:001020_10 | 4.02466844341e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona glomerulosa[Supported,Not detected] |
| HPA:001030_10 | 4.02466844341e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona reticularis[Supported,Not detected] |
| HPA:001010_10 | 4.02466844341e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona fasciculata[Supported,Not detected] |
| HPA:001050_10 | 4.02466844341e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; medullary cells[Supported,Not detected] |
| WP:WP2355 | 6.3578533693e-05 | 0.6 | GNAZ HSD3B1 HSD3B2 | Corticotropin-releasing hormone signaling pathway |
| WP:WP496 | 7.00810045876e-05 | 0.4 | HSD3B1 HSD3B2 | Steroid Biosynthesis |
| HPA:001050 | 8.0482558222e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; medullary cells |
| HPA:001020 | 8.0482558222e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona glomerulosa |
| HPA:001010 | 8.0482558222e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona fasciculata |
| HPA:001030 | 8.0482558222e-05 | 0.4 | HSD3B1 HSD3B2 | adrenal gland; cells in zona reticularis |
| REAC:R-HSA-194002 | 8.09644897083e-05 | 0.4 | HSD3B1 HSD3B2 | Glucocorticoid biosynthesis |
| REAC:R-HSA-193048 | 0.000202356855584 | 0.4 | HSD3B1 HSD3B2 | Androgen biosynthesis |
| KEGG:04913 | 0.00300380253978 | 0.4 | HSD3B1 HSD3B2 | Ovarian steroidogenesis |
| REAC:R-HSA-196071 | 0.00340529843133 | 0.4 | HSD3B1 HSD3B2 | Metabolism of steroid hormones |
| KEGG:00140 | 0.00403884103568 | 0.4 | HSD3B1 HSD3B2 | Steroid hormone biosynthesis |
| GO:0051412 | 0.00450823411379 | 0.4 | HSD3B1 HSD3B2 | response to corticosterone |
| KEGG:04927 | 0.00680203716674 | 0.4 | HSD3B1 HSD3B2 | Cortisol synthesis and secretion |
| GO:0051385 | 0.0135228859698 | 0.4 | HSD3B1 HSD3B2 | response to mineralocorticoid |
| KEGG:04925 | 0.0162467151192 | 0.4 | HSD3B1 HSD3B2 | Aldosterone synthesis and secretion |
| GO:0003854 | 0.0270421395626 | 0.4 | HSD3B1 HSD3B2 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity |
| GO:0097425 | 0.0270421395626 | 0.4 | HSD3B1 HSD3B2 | smooth endoplasmic reticulum part |
| GO:0030868 | 0.0270421395626 | 0.4 | HSD3B1 HSD3B2 | smooth endoplasmic reticulum membrane |
| GO:0004769 | 0.0270421395626 | 0.4 | HSD3B1 HSD3B2 | steroid delta-isomerase activity |
| WP:WP1495 | 0.0372906105173 | 0.2 | MTHFR | Glycine Metabolism |
| KEGG:04934 | 0.0415917953149 | 0.4 | HSD3B1 HSD3B2 | Cushing syndrome |
| HP:0008207 | 0.0478196851342 | 0.4 | MTHFR HSD3B2 | Primary adrenal insufficiency |
| HPA:001020_03 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona glomerulosa[Uncertain,High] |
| HPA:001010_13 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona fasciculata[Supported,High] |
| HPA:001010_12 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona fasciculata[Supported,Medium] |
| HPA:001020_12 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona glomerulosa[Supported,Medium] |
| HPA:001020_13 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona glomerulosa[Supported,High] |
| HPA:001010_03 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona fasciculata[Uncertain,High] |
| HPA:001010_02 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona fasciculata[Uncertain,Medium] |
| HPA:001020_02 | 0.0499561984052 | 0.2 | HSD3B2 | adrenal gland; cells in zona glomerulosa[Uncertain,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSD3B1 | HSD3B2 | 1.0 | 0.949 | bioplex (HSD3B2) bioplex_WMM |
| HSD3B2 | TMEM38A | 0.722 | 0.732 | bioplex (HSD3B2) bioplex_WMM |
| HSD3B2 | MTHFR | 0.246 | 0.47 | bioplex (HSD3B2) bioplex_WMM |
| MTHFR | GNAZ | 0.046 | 0.293 | bioplex (GNAZ) bioplex_WMM |
| HSD3B1 | TMEM38A | 0.008 | 0.091 | bioplex_WMM WMM_only |
| HSD3B1 | MTHFR | 0.008 | 0.033 | bioplex_WMM WMM_only |
| TMEM38A | MTHFR | 0.008 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00093 has an average edge precision of 0.368 which is ranked 3662 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSD3B1 | HuMAP2_00093 HuMAP2_00395 |
| HSD3B2 | HuMAP2_00093 HuMAP2_00395 |
| TMEM38A | HuMAP2_00093 HuMAP2_00395 |
| MTHFR | HuMAP2_00093 HuMAP2_05767 HuMAP2_06727 |
| GNAZ | HuMAP2_00093 HuMAP2_03496 HuMAP2_05767 HuMAP2_06727 |