hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00097

Confidence: Medium

Genename	Protein Name	Links
CAMKMT	Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60)	UniProt NCBI
TIMM44	Mitochondrial import inner membrane translocase subunit TIM44	UniProt NCBI
ERAL1	GTPase Era, mitochondrial (H-ERA) (hERA) (Conserved ERA-like GTPase) (CEGA) (ERA-W) (ERA-like protein 1)	UniProt NCBI
COL1A2	Collagen alpha-2(I) chain (Alpha-2 type I collagen)	UniProt NCBI
COL3A1	Collagen alpha-1(III) chain	UniProt NCBI
COL1A1	Collagen alpha-1(I) chain (Alpha-1 type I collagen)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP453	1.99108246857e-06	0.5	COL3A1 COL1A2 COL1A1	Inflammatory Response Pathway
REAC:R-HSA-3000480	4.04105473372e-06	0.5	COL3A1 COL1A2 COL1A1	Scavenging by Class A Receptors
REAC:R-HSA-3000170	1.54300761667e-05	0.5	COL3A1 COL1A2 COL1A1	Syndecan interactions
REAC:R-HSA-8874081	1.94360151212e-05	0.5	COL3A1 COL1A2 COL1A1	MET activates PTK2 signaling
HP:0001075	3.56342540167e-05	0.5	COL3A1 COL1A2 COL1A1	Atrophic scars
REAC:R-HSA-2173782	3.878939824e-05	0.5	COL3A1 COL1A2 COL1A1	Binding and Uptake of Ligands by Scavenger Receptors
REAC:R-HSA-8875878	4.60355113742e-05	0.5	COL3A1 COL1A2 COL1A1	MET promotes cell motility
REAC:R-HSA-8948216	5.41301437531e-05	0.5	COL3A1 COL1A2 COL1A1	Collagen chain trimerization
HP:0005897	7.51372352298e-05	0.333333333333	COL1A1 COL1A2	Severe generalized osteoporosis
HP:0003321	7.51372352298e-05	0.333333333333	COL1A1 COL1A2	Biconcave flattened vertebrae
HP:0005005	7.51372352298e-05	0.333333333333	COL1A1 COL1A2	Femoral bowing present at birth, straightening with time
HP:0005623	7.51372352298e-05	0.333333333333	COL1A1 COL1A2	Absent ossification of calvaria
KEGG:04974	0.000112334489723	0.5	COL3A1 COL1A2 COL1A1	Protein digestion and absorption
REAC:R-HSA-2022090	0.000163763058745	0.5	COL3A1 COL1A2 COL1A1	Assembly of collagen fibrils and other multimeric structures
KEGG:05146	0.000164064689456	0.5	COL3A1 COL1A2 COL1A1	Amoebiasis
REAC:R-HSA-3000171	0.000172834826973	0.5	COL3A1 COL1A2 COL1A1	Non-integrin membrane-ECM interactions
KEGG:04933	0.000201612526794	0.5	COL3A1 COL1A2 COL1A1	AGE-RAGE signaling pathway in diabetic complications
REAC:R-HSA-1442490	0.000202041038028	0.5	COL3A1 COL1A2 COL1A1	Collagen degradation
REAC:R-HSA-1650814	0.000223228442122	0.5	COL3A1 COL1A2 COL1A1	Collagen biosynthesis and modifying enzymes
MIRNA:hsa-miR-29c-3p	0.00025851001766	0.666666666667	TIMM44 COL3A1 COL1A2 COL1A1	hsa-miR-29c-3p
REAC:R-HSA-3000178	0.000269929792646	0.5	COL3A1 COL1A2 COL1A1	ECM proteoglycans
GO:0098643	0.000299339163023	0.5	COL3A1 COL1A2 COL1A1	banded collagen fibril
GO:0005583	0.000299339163023	0.5	COL3A1 COL1A2 COL1A1	fibrillar collagen trimer
GO:0048407	0.000299339163023	0.5	COL3A1 COL1A2 COL1A1	platelet-derived growth factor binding
REAC:R-HSA-6806834	0.00036649373235	0.5	COL3A1 COL1A2 COL1A1	Signaling by MET
KEGG:04611	0.000367001333139	0.5	COL3A1 COL1A2 COL1A1	Platelet activation
REAC:R-HSA-216083	0.000397774586562	0.5	COL3A1 COL1A2 COL1A1	Integrin cell surface interactions
HP:0003023	0.00045066196833	0.333333333333	COL1A1 COL1A2	Bowing of limbs due to multiple fractures
KEGG:04926	0.000464025836468	0.5	COL3A1 COL1A2 COL1A1	Relaxin signaling pathway
REAC:R-HSA-198933	0.000502143964773	0.5	COL3A1 COL1A2 COL1A1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
REAC:R-HSA-1474290	0.000560531240275	0.5	COL3A1 COL1A2 COL1A1	Collagen formation
HP:0000444	0.000617572732129	0.5	COL3A1 COL1A2 COL1A1	Convex nasal ridge
REAC:R-HSA-430116	0.000620139265586	0.333333333333	COL1A1 COL1A2	GP1b-IX-V activation signalling
WP:WP3967	0.000668966778113	0.333333333333	COL3A1 COL1A1	miR-509-3p alteration of YAP1/ECM axis
HP:0000362	0.000750968775169	0.333333333333	COL1A1 COL1A2	Otosclerosis
HP:0005758	0.000750968775169	0.333333333333	COL1A1 COL1A2	Basilar impression
REAC:R-HSA-75892	0.000797179114843	0.333333333333	COL1A1 COL1A2	Platelet Adhesion to exposed collagen
HP:0004334	0.000957496450896	0.5	COL3A1 COL1A2 COL1A1	Dermal atrophy
HP:0000592	0.000957496450896	0.5	COL3A1 COL1A2 COL1A1	Blue sclerae
HP:0001634	0.00100153681794	0.5	COL3A1 COL1A2 COL1A1	Mitral valve prolapse
HP:0000963	0.00100153681794	0.5	COL3A1 COL1A2 COL1A1	Thin skin
HP:0006367	0.00112625143517	0.333333333333	COL1A1 COL1A2	Crumpled long bones
HP:0100823	0.00112625143517	0.333333333333	COL3A1 COL1A1	Genital hernia
HP:0000923	0.00112625143517	0.333333333333	COL1A1 COL1A2	Beaded ribs
WP:WP2911	0.00116964360656	0.333333333333	COL3A1 COL1A2	miRNA targets in ECM and membrane receptors
GO:0098644	0.00147880241807	0.5	COL3A1 COL1A2 COL1A1	complex of collagen trimers
HP:0000703	0.0015764696333	0.333333333333	COL1A1 COL1A2	Dentinogenesis imperfecta
HP:0001633	0.00157771149807	0.5	COL3A1 COL1A2 COL1A1	Abnormal mitral valve morphology
HP:0000591	0.00170171010284	0.5	COL3A1 COL1A2 COL1A1	Abnormal sclera morphology
REAC:R-HSA-1474228	0.00199485952479	0.5	COL3A1 COL1A2 COL1A1	Degradation of the extracellular matrix
HP:0005294	0.00210158306671	0.333333333333	COL3A1 COL1A1	Arterial dissection
HP:0010299	0.00210158306671	0.333333333333	COL1A1 COL1A2	Abnormality of dentin
HP:0008628	0.00210158306671	0.333333333333	COL1A1 COL1A2	Abnormality of the stapes
REAC:R-HSA-2214320	0.00232260810736	0.333333333333	COL1A1 COL1A2	Anchoring fibril formation
HP:0008921	0.00270155144475	0.333333333333	COL1A1 COL1A2	Neonatal short-limb short stature
HP:0006705	0.00302574748504	0.5	COL3A1 COL1A2 COL1A1	Abnormal atrioventricular valve morphology
HP:0003179	0.00337633448894	0.333333333333	COL1A1 COL1A2	Protrusio acetabuli
HP:0005474	0.00337633448894	0.333333333333	COL1A1 COL1A2	Decreased calvarial ossification
REAC:R-HSA-2243919	0.00338255333894	0.333333333333	COL1A1 COL1A2	Crosslinking of collagen fibrils
WP:WP3932	0.00399196485232	0.5	COL3A1 COL1A2 COL1A1	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
HP:0001622	0.00405525264868	0.5	COL3A1 COL1A2 COL1A1	Premature birth
HP:0008067	0.00416939096982	0.5	COL3A1 COL1A2 COL1A1	Abnormally lax or hyperextensible skin
HP:0000987	0.00440401599767	0.5	COL3A1 COL1A2 COL1A1	Atypical scarring of skin
HP:0000978	0.00452454045934	0.5	COL3A1 COL1A2 COL1A1	Bruising susceptibility
HP:0004452	0.00495018352279	0.333333333333	COL1A1 COL1A2	Abnormality of the middle ear ossicles
HP:0010547	0.00495018352279	0.333333333333	COL1A1 COL1A2	Muscle flaccidity
HP:0040160	0.00584916901642	0.333333333333	COL1A1 COL1A2	Generalized osteoporosis
HP:0100699	0.00660291451448	0.5	COL3A1 COL1A2 COL1A1	Scarring
GO:0005584	0.00676235117068	0.333333333333	COL1A1 COL1A2	collagen type I trimer
HP:0001790	0.00682280818411	0.333333333333	COL1A1 COL1A2	Nonimmune hydrops fetalis
HP:0005855	0.00682280818411	0.333333333333	COL1A1 COL1A2	Multiple prenatal fractures
HP:0002691	0.00682280818411	0.333333333333	COL1A1 COL1A2	Platybasia
GO:0005581	0.00734442516369	0.5	COL3A1 COL1A2 COL1A1	collagen trimer
HP:0008609	0.00787106080828	0.333333333333	COL1A1 COL1A2	Morphological abnormality of the middle ear
REAC:R-HSA-114604	0.00834193552282	0.333333333333	COL1A1 COL1A2	GPVI-mediated activation cascade
HP:0004970	0.00899388668352	0.333333333333	COL3A1 COL1A1	Ascending tubular aorta aneurysm
REAC:R-HSA-76009	0.00959640616298	0.333333333333	COL1A1 COL1A2	Platelet Aggregation (Plug Formation)
HP:0008065	0.00982946309918	0.5	COL3A1 COL1A2 COL1A1	Aplasia/Hypoplasia of the skin
HP:0004586	0.0101912456166	0.333333333333	COL1A1 COL1A2	Biconcave vertebral bodies
HP:0000015	0.0101912456166	0.333333333333	COL3A1 COL1A2	Bladder diverticulum
HP:0100541	0.0101912456166	0.333333333333	COL1A1 COL1A2	Femoral hernia
HP:0005743	0.0101912456166	0.333333333333	COL1A1 COL1A2	Avascular necrosis of the capital femoral epiphysis
HP:0010647	0.0106650876034	0.5	COL3A1 COL1A2 COL1A1	Abnormal elasticity of skin
GO:0030199	0.0108183376095	0.5	COL3A1 COL1A2 COL1A1	collagen fibril organization
HP:0010444	0.0114630974264	0.333333333333	COL1A1 COL1A2	Pulmonary insufficiency
HP:0001623	0.0114630974264	0.333333333333	COL1A1 COL1A2	Breech presentation
GO:0030020	0.0129043378459	0.5	COL3A1 COL1A2 COL1A1	extracellular matrix structural constituent conferring tensile strength
GO:0044420	0.0140408309691	0.5	COL3A1 COL1A2 COL1A1	extracellular matrix component
HP:0005692	0.015007845	0.5	COL3A1 COL1A2 COL1A1	Joint hyperflexibility
HP:0009124	0.0166795319196	0.5	COL3A1 COL1A2 COL1A1	Abnormal adipose tissue morphology
HP:0001030	0.0172946302375	0.333333333333	COL3A1 COL1A2	Fragile skin
REAC:R-HSA-1474244	0.0179459751507	0.5	COL3A1 COL1A2 COL1A1	Extracellular matrix organization
KEGG:04512	0.0185486461013	0.333333333333	COL1A1 COL1A2	ECM-receptor interaction
HP:0011119	0.0187800119955	0.5	COL3A1 COL1A2 COL1A1	Abnormality of the nasal dorsum
HP:0002982	0.0189383441407	0.333333333333	COL1A1 COL1A2	Tibial bowing
HP:0000977	0.0189383441407	0.333333333333	COL1A1 COL1A2	Soft skin
HP:0001933	0.0197311756416	0.5	COL3A1 COL1A2 COL1A1	Subcutaneous hemorrhage
HP:0002827	0.0197311756416	0.5	COL3A1 COL1A2 COL1A1	Hip dislocation
GO:0043589	0.020283420769	0.333333333333	COL1A1 COL1A2	skin morphogenesis
HP:0100323	0.0206563100896	0.333333333333	COL1A1 COL1A2	Juvenile aseptic necrosis
HP:0000023	0.0210481336433	0.5	COL3A1 COL1A2 COL1A1	Inguinal hernia
WP:WP615	0.021546686463	0.333333333333	COL3A1 COL1A1	Senescence and Autophagy in Cancer
HP:0002107	0.0224484879882	0.333333333333	COL3A1 COL1A1	Pneumothorax
HP:0000278	0.0242205618962	0.5	COL3A1 COL1A2 COL1A1	Retrognathia
HP:0001197	0.024687191507	0.666666666667	COL3A1 COL1A2 CAMKMT COL1A1	Abnormality of prenatal development or birth
HP:0004331	0.030358517586	0.333333333333	COL1A1 COL1A2	Decreased skull ossification
HP:0001654	0.0314796075901	0.5	COL3A1 COL1A2 COL1A1	Abnormal heart valve morphology
HP:0030311	0.032813556514	0.5	COL3A1 COL1A2 COL1A1	Lower extremity joint dislocation
HP:0003100	0.0370683023611	0.333333333333	COL1A1 COL1A2	Slender long bone
HP:0010318	0.0394527338604	0.333333333333	COL3A1 COL1A1	Aplasia/Hypoplasia of the abdominal wall musculature
HP:0001384	0.0405599116431	0.5	COL3A1 COL1A2 COL1A1	Abnormality of the hip joint
HP:0001382	0.0410803928175	0.5	COL3A1 COL1A2 COL1A1	Joint hypermobility
HP:0000422	0.0417453492809	0.666666666667	COL3A1 COL1A2 CAMKMT COL1A1	Abnormality of the nasal bridge
HP:0002980	0.0419110169922	0.333333333333	COL1A1 COL1A2	Femoral bowing
HP:0010529	0.0419110169922	0.333333333333	COL1A1 COL1A2	Echolalia
HP:0005262	0.0442958584683	0.5	COL3A1 COL1A2 COL1A1	Abnormality of the synovia
HP:0002703	0.044443111782	0.333333333333	COL1A1 COL1A2	Abnormality of skull ossification
HP:0011061	0.0459638888097	0.5	COL3A1 COL1A2 COL1A1	Abnormality of dental structure
HP:0005293	0.0470489782673	0.333333333333	COL3A1 COL1A1	Venous insufficiency

Edges

Protein 1	Protein 2	Score	Precision	Evidence
COL1A2	CAMKMT	0.775	0.752	bioplex (CAMKMT) bioplex_WMM
COL1A2	ERAL1	0.588	0.662	bioplex (ERAL1) bioplex_WMM
COL1A1	ERAL1	0.081	0.351	bioplex (ERAL1) bioplex_WMM
COL1A1	CAMKMT	0.072	0.353	bioplex (CAMKMT) bioplex_WMM
COL3A1	ERAL1	0.071	0.353	bioplex (ERAL1) bioplex_WMM
COL1A2	TIMM44	0.025	0.217	bioplex (TIMM44) bioplex_WMM boldt boldt_WMM
COL3A1	TIMM44	0.024	0.213	bioplex (TIMM44) bioplex_WMM
COL1A2	COL1A1	0.014	0.144	bioplex_WMM boldt boldt_WMM treiber_WMM
COL1A2	COL3A1	0.01	0.099	bioplex_WMM WMM_only
COL3A1	COL1A1	0.009	0.111	bioplex_WMM WMM_only
COL1A1	TIMM44	0.009	0.113	bioplex (TIMM44) bioplex_WMM
CAMKMT	TIMM44	0.007	0.006	bioplex (CAMKMT)
ERAL1	TIMM44	0.006	0.009	bioplex (ERAL1) bioplex_WMM youn_WMM treiber_WMM

Images

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Complex HuMAP2_00097 has an average edge precision of 0.26 which is ranked 5225 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CAMKMT	HuMAP2_00097 HuMAP2_00824 HuMAP2_02515 HuMAP2_03006 HuMAP2_04189
TIMM44	HuMAP2_00097 HuMAP2_02801 HuMAP2_04189
ERAL1	HuMAP2_00097 HuMAP2_02515 HuMAP2_03006 HuMAP2_03686 HuMAP2_03923
COL1A2	HuMAP2_00097 HuMAP2_00824 HuMAP2_02515 HuMAP2_03006 HuMAP2_04189
COL3A1	HuMAP2_00097 HuMAP2_03006 HuMAP2_04189
COL1A1	HuMAP2_00097 HuMAP2_03006 HuMAP2_04189

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00097