hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00105
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP5MD | ATP synthase membrane subunit DAPIT, mitochondrial (Diabetes-associated protein in insulin-sensitive tissues) (HCV F-transactivated protein 2) (Up-regulated during skeletal muscle growth protein 5) | UniProt NCBI |
| DNAJA1 | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | UniProt NCBI |
| SLC7A5 | Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter) | UniProt NCBI |
| DNAJA2 | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | UniProt NCBI |
| NCSTN | Nicastrin | UniProt NCBI |
| TUBA1C | Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | UniProt NCBI |
| TUBA3E | Tubulin alpha-3E chain (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain] | UniProt NCBI |
| ENDOG | Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-) | UniProt NCBI |
| TUBA1B | Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371497 | 1.05756449505e-08 | 0.555555555556 | TUBA1B TUBA3E DNAJA1 DNAJA2 TUBA1C | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| REAC:R-HSA-190840 | 2.05802714271e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 2.46888590758e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Transport of connexons to the plasma membrane |
| KEGG:04210 | 2.95131472279e-05 | 0.444444444444 | TUBA3E TUBA1B ENDOG TUBA1C | Apoptosis |
| REAC:R-HSA-389977 | 4.02039297847e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-190861 | 5.35023353638e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Gap junction assembly |
| REAC:R-HSA-9619483 | 6.11270357961e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 6.11270357961e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-5626467 | 9.8819187137e-05 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.000135466824601 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-190828 | 0.000180177547323 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.000197009576918 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Gap junction trafficking and regulation |
| WP:WP2272 | 0.000198940296053 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Pathogenic Escherichia coli infection |
| REAC:R-HSA-8955332 | 0.000233741537372 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 0.000253699748551 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-2262752 | 0.000340931457687 | 0.555555555556 | TUBA1B TUBA3E DNAJA1 DNAJA2 TUBA1C | Cellular responses to stress |
| WP:WP2359 | 0.000410180881142 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-437239 | 0.000425839414749 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 0.000587303046652 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | COPI-independent Golgi-to-ER retrograde traffic |
| KEGG:04540 | 0.000725993795643 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Gap junction |
| REAC:R-HSA-8953897 | 0.000832758677409 | 0.555555555556 | TUBA1B TUBA3E DNAJA1 DNAJA2 TUBA1C | Cellular responses to external stimuli |
| REAC:R-HSA-983189 | 0.000874903450842 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Kinesins |
| REAC:R-HSA-1445148 | 0.00149353522347 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 0.00185073287359 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 0.00208997882383 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-442755 | 0.00282588023244 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Activation of NMDA receptors and postsynaptic events |
| KEGG:04145 | 0.00300838722955 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Phagosome |
| REAC:R-HSA-380320 | 0.00347782665614 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-390466 | 0.00347782665614 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Chaperonin-mediated protein folding |
| KEGG:04530 | 0.00372212913023 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Tight junction |
| REAC:R-HSA-391251 | 0.00422207068777 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Protein folding |
| REAC:R-HSA-6811434 | 0.00422207068777 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.00435549690598 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | COPI-mediated anterograde transport |
| REAC:R-HSA-373760 | 0.00652483358031 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | L1CAM interactions |
| KEGG:05130 | 0.00673017470033 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2132295 | 0.00744439190396 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 0.00823856739508 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.010463248761 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.0112001776415 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | RHO GTPases Activate Formins |
| REAC:R-HSA-199977 | 0.0141926829916 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | ER to Golgi Anterograde Transport |
| MIRNA:hsa-miR-16-5p | 0.018270280482 | 0.666666666667 | DNAJA1 ATP5MD TUBA1C SLC7A5 NCSTN DNAJA2 | hsa-miR-16-5p |
| REAC:R-HSA-983231 | 0.0190569238164 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-948021 | 0.0228397693192 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 0.025329151298 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 0.0289155875479 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Separation of Sister Chromatids |
| REAC:R-HSA-422475 | 0.0304159320284 | 0.444444444444 | TUBA1B TUBA3E NCSTN TUBA1C | Axon guidance |
| REAC:R-HSA-69275 | 0.0323131842659 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | G2/M Transition |
| REAC:R-HSA-68877 | 0.032818837313 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.032818837313 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Mitotic Anaphase |
| REAC:R-HSA-5617833 | 0.032818837313 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Cilium Assembly |
| REAC:R-HSA-2555396 | 0.0333296326556 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.0333296326556 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.0359615772046 | 0.333333333333 | TUBA3E TUBA1B TUBA1C | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-109582 | 0.0360381630385 | 0.444444444444 | TUBA3E SLC7A5 TUBA1B TUBA1C | Hemostasis |
| HPA:031010_22 | 0.041797512771 | 0.555555555556 | NCSTN SLC7A5 DNAJA1 DNAJA2 ENDOG | ovary; follicle cells[Approved,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBA1C | DNAJA1 | 0.555 | 0.647 | hein_WMM bioplex (DNAJA1,TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM fraction boldt_WMM treiber_WMM |
| ENDOG | DNAJA1 | 0.453 | 0.594 | bioplex (DNAJA1) bioplex_WMM boldt boldt_WMM |
| TUBA1C | TUBA1B | 0.321 | 0.512 | hein_WMM bioplex (TUBA1B,TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM |
| DNAJA2 | DNAJA1 | 0.14 | 0.407 | hein_WMM bioplex (DNAJA1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| TUBA1C | DNAJA2 | 0.074 | 0.356 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM treiber_WMM |
| TUBA1C | SLC7A5 | 0.03 | 0.23 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM |
| NCSTN | SLC7A5 | 0.026 | 0.216 | hein_WMM bioplex_WMM boldt hein (NCSTN) boldt_WMM |
| TUBA3E | TUBA1B | 0.024 | 0.216 | hein_WMM hein (TUBA3E) gupta_WMM |
| TUBA1C | ATP5MD | 0.021 | 0.188 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM |
| ATP5MD | NCSTN | 0.007 | 0.009 | bioplex_WMM boldt boldt_WMM |
| ATP5MD | SLC7A5 | 0.007 | 0.001 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ENDOG | SLC7A5 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| NCSTN | ENDOG | 0.007 | 0.0 | bioplex_WMM WMM_only |
| ENDOG | TUBA1B | 0.007 | 0.002 | bioplex_WMM boldt boldt_WMM |
| TUBA1B | DNAJA1 | 0.007 | 0.003 | hein_WMM bioplex (DNAJA1,TUBA1B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DNAJA2 | ENDOG | 0.007 | 0.004 | bioplex_WMM boldt boldt_WMM |
| DNAJA2 | SLC7A5 | 0.007 | 0.003 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TUBA1C | ENDOG | 0.007 | 0.004 | bioplex_WMM boldt boldt_WMM |
| ATP5MD | DNAJA1 | 0.006 | 0.007 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NCSTN | DNAJA1 | 0.006 | 0.007 | bioplex (NCSTN) bioplex_WMM boldt boldt_WMM |
| SLC7A5 | TUBA1B | 0.006 | 0.004 | hein_WMM bioplex (TUBA1B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DNAJA2 | TUBA1B | 0.006 | 0.008 | hein_WMM bioplex (TUBA1B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ATP5MD | TUBA1B | 0.006 | 0.008 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DNAJA2 | ATP5MD | 0.006 | 0.002 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TUBA1C | NCSTN | 0.005 | 0.006 | bioplex (TUBA1C) bioplex_WMM boldt boldt_WMM |
| SLC7A5 | DNAJA1 | 0.005 | 0.014 | hein_WMM bioplex (DNAJA1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TUBA3E | NCSTN | 0.005 | 0.011 | bioplex (TUBA3E) |
| NCSTN | TUBA1B | 0.005 | 0.009 | bioplex (TUBA1B) bioplex_WMM boldt boldt_WMM |
| TUBA3E | DNAJA2 | 0.0 | 0.017 | hein_WMM bioplex (TUBA3E) hein (TUBA3E) gupta_WMM |
| DNAJA2 | NCSTN | 0.0 | 0.008 | bioplex (NCSTN) bioplex_WMM boldt fraction boldt_WMM |
| TUBA3E | DNAJA1 | 0.0 | 0.01 | hein_WMM bioplex (TUBA3E) hein (TUBA3E) gupta_WMM |
| TUBA3E | TUBA1C | 0.0 | 0.003 | bioplex (TUBA3E) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_00105 has an average edge precision of 0.11 which is ranked 6912 out of all 6965 complexes.
Related Complexes