hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00106
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDSS1 | Decaprenyl-diphosphate synthase subunit 1 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 1) (Decaprenyl pyrophosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) | UniProt NCBI |
| PDSS2 | Decaprenyl-diphosphate synthase subunit 2 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 2) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) | UniProt NCBI |
| COA1 | Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa) | UniProt NCBI |
| THEM4 | Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Carboxyl-terminal modulator protein) (Thioesterase superfamily member 4) | UniProt NCBI |
| ACAD9 | Acyl-CoA dehydrogenase family member 9, mitochondrial (ACAD-9) (EC 1.3.99.-) | UniProt NCBI |
| GSTT2 | Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2142789 | 0.000465187760645 | 0.333333333333 | PDSS1 PDSS2 | Ubiquinol biosynthesis |
| KEGG:00900 | 0.00144121918646 | 0.333333333333 | PDSS1 PDSS2 | Terpenoid backbone biosynthesis |
| REAC:R-HSA-8978934 | 0.0030072528049 | 0.333333333333 | PDSS1 PDSS2 | Metabolism of cofactors |
| GO:0000010 | 0.00676235117068 | 0.333333333333 | PDSS1 PDSS2 | trans-hexaprenyltranstransferase activity |
| WP:WP4324 | 0.00763119022667 | 0.333333333333 | ACAD9 COA1 | Mitochondrial complex I assembly model OXPHOS system |
| HP:0002151 | 0.0104519436081 | 0.5 | PDSS1 ACAD9 PDSS2 | Increased serum lactate |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| THEM4 | GSTT2 | 0.995 | 0.924 | bioplex (THEM4) bioplex_WMM |
| THEM4 | PDSS2 | 0.156 | 0.416 | bioplex (THEM4) bioplex_WMM |
| PDSS2 | ACAD9 | 0.082 | 0.351 | bioplex (ACAD9) bioplex_WMM |
| PDSS1 | ACAD9 | 0.036 | 0.264 | bioplex (ACAD9) bioplex_WMM |
| ACAD9 | COA1 | 0.035 | 0.265 | bioplex (ACAD9) bioplex_WMM |
| THEM4 | PDSS1 | 0.016 | 0.156 | bioplex (THEM4) bioplex_WMM |
| PDSS1 | PDSS2 | 0.012 | 0.147 | bioplex_WMM WMM_only |
| PDSS2 | GSTT2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| PDSS1 | GSTT2 | 0.008 | 0.034 | bioplex_WMM WMM_only |
| PDSS2 | COA1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| PDSS1 | COA1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| THEM4 | ACAD9 | 0.005 | 0.011 | bioplex (THEM4) youn_WMM |
Images
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Complex HuMAP2_00106 has an average edge precision of 0.219 which is ranked 5872 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDSS1 | HuMAP2_00106 HuMAP2_00306 HuMAP2_04886 |
| PDSS2 | HuMAP2_00106 HuMAP2_03912 HuMAP2_05964 |
| COA1 | HuMAP2_00106 HuMAP2_00306 HuMAP2_01844 HuMAP2_05090 HuMAP2_05762 |
| THEM4 | HuMAP2_00106 HuMAP2_01008 HuMAP2_03912 HuMAP2_05964 |
| ACAD9 | HuMAP2_00106 HuMAP2_00306 HuMAP2_02635 HuMAP2_04892 HuMAP2_05964 |
| GSTT2 | HuMAP2_00106 HuMAP2_01008 HuMAP2_03912 HuMAP2_05964 |