hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00115
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SIK2 | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) | UniProt NCBI |
| IER5 | Immediate early response gene 5 protein | UniProt NCBI |
| SIK1 | Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK) | UniProt NCBI |
| ZNF746 | Zinc finger protein 746 (Parkin-interacting substrate) (PARIS) | UniProt NCBI |
| CDCA4 | Cell division cycle-associated protein 4 (Hematopoietic progenitor protein) | UniProt NCBI |
| PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) | UniProt NCBI |
| PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (IMYPNO1) (PP2A subunit B isoform B55-gamma) (PP2A subunit B isoform PR55-gamma) (PP2A subunit B isoform R2-gamma) (PP2A subunit B isoform gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000159 | 0.00307019549622 | 0.428571428571 | IER5 PPP2R2C PPP2R2B | protein phosphatase type 2A complex |
| MIRNA:hsa-miR-142-3p | 0.00315602149923 | 0.571428571429 | SIK1 SIK2 PPP2R2C CDCA4 | hsa-miR-142-3p |
| HPA:047020 | 0.00672662319097 | 1.0 | PPP2R2B IER5 CDCA4 SIK1 PPP2R2C SIK2 ZNF746 | soft tissue 1; chondrocytes |
| WP:WP500 | 0.00702347294811 | 0.285714285714 | PPP2R2B PPP2R2C | Glycogen Synthesis and Degradation |
| HPA:047020_20 | 0.016089849873 | 0.857142857143 | PPP2R2B SIK1 CDCA4 PPP2R2C ZNF746 SIK2 | soft tissue 1; chondrocytes[Approved,Not detected] |
| GO:0008287 | 0.0288395886243 | 0.428571428571 | IER5 PPP2R2C PPP2R2B | protein serine/threonine phosphatase complex |
| GO:1903293 | 0.0288395886243 | 0.428571428571 | IER5 PPP2R2C PPP2R2B | phosphatase complex |
| KEGG:03015 | 0.0372632222286 | 0.285714285714 | PPP2R2B PPP2R2C | mRNA surveillance pathway |
| KEGG:05142 | 0.0372632222286 | 0.285714285714 | PPP2R2B PPP2R2C | Chagas disease (American trypanosomiasis) |
| HPA:047020_22 | 0.0381525010884 | 0.571428571429 | SIK1 SIK2 PPP2R2C PPP2R2B | soft tissue 1; chondrocytes[Approved,Medium] |
| KEGG:04922 | 0.0443092098146 | 0.285714285714 | SIK1 SIK2 | Glucagon signaling pathway |
| WP:WP399 | 0.0459055538129 | 0.285714285714 | PPP2R2B PPP2R2C | Wnt Signaling Pathway and Pluripotency |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IER5 | PPP2R2C | 0.725 | 0.735 | bioplex (PPP2R2C) bioplex_WMM |
| PPP2R2B | PPP2R2C | 0.073 | 0.357 | bioplex (PPP2R2C) bioplex_WMM |
| PPP2R2C | CDCA4 | 0.035 | 0.261 | bioplex (PPP2R2C) bioplex_WMM |
| ZNF746 | PPP2R2C | 0.034 | 0.265 | bioplex (PPP2R2C) bioplex_WMM |
| SIK1 | SIK2 | 0.031 | 0.241 | bioplex (SIK1) bioplex_WMM |
| PPP2R2C | SIK2 | 0.027 | 0.232 | bioplex (PPP2R2C) bioplex_WMM |
| IER5 | CDCA4 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| PPP2R2B | CDCA4 | 0.01 | 0.134 | hein_WMM bioplex_WMM WMM_only |
| IER5 | PPP2R2B | 0.009 | 0.104 | bioplex_WMM WMM_only |
| ZNF746 | PPP2R2B | 0.009 | 0.092 | bioplex_WMM WMM_only |
| PPP2R2B | SIK2 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| IER5 | ZNF746 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| IER5 | SIK2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| ZNF746 | CDCA4 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| CDCA4 | SIK2 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ZNF746 | SIK2 | 0.008 | 0.083 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00115 has an average edge precision of 0.194 which is ranked 6263 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SIK2 | HuMAP2_00115 HuMAP2_05869 HuMAP2_06073 |
| IER5 | HuMAP2_00115 HuMAP2_00202 HuMAP2_00704 HuMAP2_06073 |
| SIK1 | HuMAP2_00115 HuMAP2_05869 HuMAP2_06073 |
| ZNF746 | HuMAP2_00115 HuMAP2_02242 HuMAP2_05813 HuMAP2_06319 |
| CDCA4 | HuMAP2_00115 HuMAP2_02007 HuMAP2_03797 HuMAP2_04512 |
| PPP2R2B | HuMAP2_00115 HuMAP2_00704 HuMAP2_06073 |
| PPP2R2C | HuMAP2_00115 HuMAP2_00202 HuMAP2_00704 HuMAP2_06073 |