hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00137
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EPS15 | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | UniProt NCBI |
| DAB2 | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | UniProt NCBI |
| FCHO1 | F-BAR domain only protein 1 | UniProt NCBI |
| FCHO2 | F-BAR domain only protein 2 | UniProt NCBI |
| SLC25A41 | Solute carrier family 25 member 41 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 8.87616987911e-07 | 0.8 | FCHO1 FCHO2 EPS15 DAB2 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 3.99365490063e-06 | 0.8 | FCHO1 FCHO2 EPS15 DAB2 | Clathrin-mediated endocytosis |
| GO:0005905 | 4.983554895e-06 | 0.8 | FCHO1 FCHO2 EPS15 DAB2 | clathrin-coated pit |
| GO:0048268 | 0.000199619769136 | 0.6 | FCHO2 EPS15 FCHO1 | clathrin coat assembly |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | FCHO1 FCHO2 EPS15 DAB2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | FCHO1 FCHO2 EPS15 DAB2 | Vesicle-mediated transport |
| GO:0072583 | 0.00407078924856 | 0.6 | FCHO2 DAB2 FCHO1 | clathrin-dependent endocytosis |
| GO:0006898 | 0.00558300460276 | 0.8 | FCHO1 FCHO2 EPS15 DAB2 | receptor-mediated endocytosis |
| CORUM:3231 | 0.0499494897235 | 0.2 | EPS15 | Eps15-stonin2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DAB2 | FCHO2 | 0.925 | 0.843 | hein_WMM bioplex (DAB2) bioplex_WMM |
| FCHO2 | FCHO1 | 0.267 | 0.483 | bioplex (FCHO1) bioplex_WMM |
| DAB2 | SLC25A41 | 0.043 | 0.269 | bioplex (SLC25A41) bioplex_WMM |
| FCHO2 | SLC25A41 | 0.031 | 0.238 | bioplex (SLC25A41) bioplex_WMM |
| EPS15 | FCHO1 | 0.03 | 0.238 | bioplex (FCHO1) bioplex_WMM |
| EPS15 | FCHO2 | 0.021 | 0.185 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| EPS15 | DAB2 | 0.008 | 0.083 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| EPS15 | SLC25A41 | 0.0 | 0.012 | bioplex (SLC25A41) bioplex_WMM |
Images
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Complex HuMAP2_00137 has an average edge precision of 0.294 which is ranked 4695 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EPS15 | HuMAP2_00137 HuMAP2_01298 HuMAP2_02111 HuMAP2_04081 HuMAP2_06613 HuMAP2_06848 |
| DAB2 | HuMAP2_00137 HuMAP2_00532 HuMAP2_01298 HuMAP2_04526 HuMAP2_06848 |
| FCHO1 | HuMAP2_00137 HuMAP2_00532 HuMAP2_01298 |
| FCHO2 | HuMAP2_00137 HuMAP2_00532 HuMAP2_01298 HuMAP2_03002 HuMAP2_04526 |
| SLC25A41 | HuMAP2_00137 HuMAP2_00532 HuMAP2_01298 HuMAP2_01870 |