hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00141
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TLR1 | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) | UniProt NCBI |
| TLR6 | Toll-like receptor 6 (CD antigen CD286) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3877 | 3.91210398304e-05 | 1.0 | TLR6 TLR1 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| REAC:R-HSA-5602498 | 6.03332446455e-05 | 1.0 | TLR6 TLR1 | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5603041 | 7.54165558069e-05 | 1.0 | TLR6 TLR1 | IRAK4 deficiency (TLR2/4) |
| WP:WP3858 | 0.000140835743389 | 1.0 | TLR6 TLR1 | Toll-like Receptor Signaling |
| REAC:R-HSA-5686938 | 0.000227925590883 | 1.0 | TLR6 TLR1 | Regulation of TLR by endogenous ligand |
| REAC:R-HSA-5260271 | 0.000424008635981 | 1.0 | TLR6 TLR1 | Diseases of Immune System |
| REAC:R-HSA-5602358 | 0.000424008635981 | 1.0 | TLR6 TLR1 | Diseases associated with the TLR signaling cascade |
| KEGG:04620 | 0.000533255523815 | 1.0 | TLR6 TLR1 | Toll-like receptor signaling pathway |
| GO:0035663 | 0.00135247023414 | 1.0 | TLR6 TLR1 | Toll-like receptor 2 binding |
| GO:0070340 | 0.00135247023414 | 1.0 | TLR6 TLR1 | detection of bacterial lipopeptide |
| WP:WP75 | 0.00142624133782 | 1.0 | TLR6 TLR1 | Toll-like Receptor Signaling Pathway |
| KEGG:05152 | 0.00163040505571 | 1.0 | TLR6 TLR1 | Tuberculosis |
| WP:WP1449 | 0.00257192893285 | 1.0 | TLR6 TLR1 | Regulation of toll-like receptor signaling pathway |
| GO:0042494 | 0.00270494046827 | 1.0 | TLR6 TLR1 | detection of bacterial lipoprotein |
| REAC:R-HSA-1236974 | 0.00556574181855 | 1.0 | TLR6 TLR1 | ER-Phagosome pathway |
| REAC:R-HSA-168188 | 0.00656291627866 | 1.0 | TLR6 TLR1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00656291627866 | 1.0 | TLR6 TLR1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| GO:0070339 | 0.00676235117068 | 1.0 | TLR6 TLR1 | response to bacterial lipopeptide |
| GO:0071220 | 0.00676235117068 | 1.0 | TLR6 TLR1 | cellular response to bacterial lipoprotein |
| GO:0071221 | 0.00676235117068 | 1.0 | TLR6 TLR1 | cellular response to bacterial lipopeptide |
| REAC:R-HSA-168179 | 0.0070154156135 | 1.0 | TLR6 TLR1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.0070154156135 | 1.0 | TLR6 TLR1 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-1236975 | 0.00732546145404 | 1.0 | TLR6 TLR1 | Antigen processing-Cross presentation |
| GO:0071723 | 0.00946729163895 | 1.0 | TLR6 TLR1 | lipopeptide binding |
| GO:0032493 | 0.00946729163895 | 1.0 | TLR6 TLR1 | response to bacterial lipoprotein |
| REAC:R-HSA-166016 | 0.0115688996608 | 1.0 | TLR6 TLR1 | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0034135 | 0.0162296428096 | 1.0 | TLR6 TLR1 | regulation of toll-like receptor 2 signaling pathway |
| GO:0032490 | 0.0162296428096 | 1.0 | TLR6 TLR1 | detection of molecule of bacterial origin |
| REAC:R-HSA-168898 | 0.0163067352889 | 1.0 | TLR6 TLR1 | Toll-like Receptor Cascades |
| GO:0045410 | 0.020287053512 | 1.0 | TLR6 TLR1 | positive regulation of interleukin-6 biosynthetic process |
| GO:0016045 | 0.020287053512 | 1.0 | TLR6 TLR1 | detection of bacterium |
| GO:0035325 | 0.020287053512 | 1.0 | TLR6 TLR1 | Toll-like receptor binding |
| GO:0098543 | 0.0247952876258 | 1.0 | TLR6 TLR1 | detection of other organism |
| GO:0045408 | 0.029754345151 | 1.0 | TLR6 TLR1 | regulation of interleukin-6 biosynthetic process |
| GO:0042226 | 0.0351642260875 | 1.0 | TLR6 TLR1 | interleukin-6 biosynthetic process |
| GO:0034134 | 0.0351642260875 | 1.0 | TLR6 TLR1 | toll-like receptor 2 signaling pathway |
| GO:0098581 | 0.0410249304355 | 1.0 | TLR6 TLR1 | detection of external biotic stimulus |
| CORUM:7048 | 0.0499173803268 | 0.5 | TLR1 | TLR1-TLR2 complex |
| CORUM:7049 | 0.0499173803268 | 0.5 | TLR1 | TLR1-TLR2-lipoprotein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TLR1 | TLR6 | 0.977 | 0.893 | bioplex (TLR1) bioplex_WMM |
Images
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Complex HuMAP2_00141 has an average edge precision of 0.893 which is ranked 607 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TLR1 | HuMAP2_00141 HuMAP2_02098 HuMAP2_04974 |
| TLR6 | HuMAP2_00141 HuMAP2_02098 HuMAP2_04974 |