hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00142
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBOX5 | RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) | UniProt NCBI |
| TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | UniProt NCBI |
| TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | UniProt NCBI |
| EMILIN1 | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | UniProt NCBI |
| TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5268 | 7.56440327173e-08 | 0.6 | TAB3 TAB1 TAB2 | TNF-alpha/NF-kappa B signaling complex 7 |
| REAC:R-HSA-937042 | 3.26064244298e-07 | 0.6 | TAB3 TAB1 TAB2 | IRAK2 mediated activation of TAK1 complex |
| REAC:R-HSA-9014325 | 4.48293159034e-07 | 0.6 | TAB3 TAB1 TAB2 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| REAC:R-HSA-937072 | 9.88662921473e-07 | 0.6 | TAB3 TAB1 TAB2 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| REAC:R-HSA-975163 | 9.88662921473e-07 | 0.6 | TAB3 TAB1 TAB2 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-450321 | 4.17943282079e-06 | 0.6 | TAB3 TAB1 TAB2 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| REAC:R-HSA-450302 | 4.80586315819e-06 | 0.6 | TAB3 TAB1 TAB2 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-5357956 | 9.90965664735e-06 | 0.6 | TAB3 TAB1 TAB2 | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-445989 | 1.10096191184e-05 | 0.6 | TAB3 TAB1 TAB2 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| WP:WP2637 | 1.233701901e-05 | 0.6 | TAB3 TAB1 TAB2 | Structural Pathway of Interleukin 1 (IL-1) |
| WP:WP195 | 1.39419534482e-05 | 0.6 | TAB3 TAB1 TAB2 | IL-1 signaling pathway |
| REAC:R-HSA-168638 | 1.77393158174e-05 | 0.6 | TAB3 TAB1 TAB2 | NOD1/2 Signaling Pathway |
| CORUM:5215 | 2.0123342217e-05 | 0.4 | TAB2 TAB1 | CS-MAP3K7IP1-MAP3K7IP2 complex |
| CORUM:2758 | 2.0123342217e-05 | 0.4 | TAB2 TAB1 | TAK1 complex |
| REAC:R-HSA-75893 | 2.67648652633e-05 | 0.6 | TAB3 TAB1 TAB2 | TNF signaling |
| REAC:R-HSA-168643 | 6.33776832781e-05 | 0.6 | TAB3 TAB1 TAB2 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04064 | 6.78759182453e-05 | 0.6 | TAB3 TAB1 TAB2 | NF-kappa B signaling pathway |
| WP:WP231 | 7.31920604822e-05 | 0.6 | TAB3 TAB1 TAB2 | TNF alpha Signaling Pathway |
| WP:WP75 | 7.31920604822e-05 | 0.6 | TAB3 TAB1 TAB2 | Toll-like Receptor Signaling Pathway |
| REAC:R-HSA-450294 | 0.000107327354708 | 0.6 | TAB3 TAB1 TAB2 | MAP kinase activation |
| KEGG:04668 | 0.000111224532588 | 0.6 | TAB3 TAB1 TAB2 | TNF signaling pathway |
| REAC:R-HSA-448424 | 0.000141520021869 | 0.6 | TAB3 TAB1 TAB2 | Interleukin-17 signaling |
| WP:WP1449 | 0.000177488738827 | 0.6 | TAB3 TAB1 TAB2 | Regulation of toll-like receptor signaling pathway |
| REAC:R-HSA-2871837 | 0.000189751148448 | 0.6 | TAB3 TAB1 TAB2 | FCERI mediated NF-kB activation |
| REAC:R-HSA-975871 | 0.000238892911782 | 0.6 | TAB3 TAB1 TAB2 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.000238892911782 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.000238892911782 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.00025697910325 | 0.6 | TAB3 TAB1 TAB2 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.000266353842167 | 0.6 | TAB3 TAB1 TAB2 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.000266353842167 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-166058 | 0.000306125075711 | 0.6 | TAB3 TAB1 TAB2 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.000306125075711 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 0.000306125075711 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.000316649083447 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-168179 | 0.000338412904811 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.000338412904811 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-5607764 | 0.000338412904811 | 0.6 | TAB3 TAB1 TAB2 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-937061 | 0.000349657961729 | 0.6 | TAB3 TAB1 TAB2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.000349657961729 | 0.6 | TAB3 TAB1 TAB2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-9020702 | 0.000397120285508 | 0.6 | TAB3 TAB1 TAB2 | Interleukin-1 signaling |
| KEGG:04621 | 0.000549173586032 | 0.6 | TAB3 TAB1 TAB2 | NOD-like receptor signaling pathway |
| CORUM:6344 | 0.000703182488552 | 0.4 | TAB2 TAB1 | TNF-R1-associated signaling complex |
| REAC:R-HSA-166016 | 0.000717394603045 | 0.6 | TAB3 TAB1 TAB2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-2454202 | 0.000754665480287 | 0.6 | TAB3 TAB1 TAB2 | Fc epsilon receptor (FCERI) signaling |
| KEGG:05130 | 0.000772172961031 | 0.6 | TAB3 TAB1 TAB2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-446652 | 0.000874143100407 | 0.6 | TAB3 TAB1 TAB2 | Interleukin-1 family signaling |
| REAC:R-HSA-5621481 | 0.000874143100407 | 0.6 | TAB3 TAB1 TAB2 | C-type lectin receptors (CLRs) |
| REAC:R-HSA-73887 | 0.000874143100407 | 0.6 | TAB3 TAB1 TAB2 | Death Receptor Signalling |
| WP:WP3851 | 0.00108182147376 | 0.4 | TAB2 TAB1 | TLR4 Signaling and Tolerance |
| REAC:R-HSA-168898 | 0.00120028939708 | 0.6 | TAB3 TAB1 TAB2 | Toll-like Receptor Cascades |
| WP:WP4329 | 0.00144719807027 | 0.4 | TAB2 TAB1 | miRNAs involvement in the immune response in sepsis |
| GO:0002755 | 0.00296772889435 | 0.6 | TAB3 TAB1 TAB2 | MyD88-dependent toll-like receptor signaling pathway |
| GO:0070423 | 0.00367721278555 | 0.6 | TAB3 TAB1 TAB2 | nucleotide-binding oligomerization domain containing signaling pathway |
| GO:0035872 | 0.00407078924856 | 0.6 | TAB3 TAB1 TAB2 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| WP:WP2018 | 0.00439842637514 | 0.4 | TAB2 TAB1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:05140 | 0.00680203716674 | 0.4 | TAB2 TAB1 | Leishmaniasis |
| KEGG:04657 | 0.0102745641273 | 0.4 | TAB3 TAB2 | IL-17 signaling pathway |
| KEGG:04620 | 0.0155166515839 | 0.4 | TAB2 TAB1 | Toll-like receptor signaling pathway |
| KEGG:05145 | 0.0185363159266 | 0.4 | TAB2 TAB1 | Toxoplasmosis |
| GO:0002753 | 0.0199719657189 | 0.6 | TAB3 TAB1 TAB2 | cytoplasmic pattern recognition receptor signaling pathway |
| KEGG:04380 | 0.0222496587654 | 0.4 | TAB2 TAB1 | Osteoclast differentiation |
| KEGG:05135 | 0.0262966325762 | 0.4 | TAB2 TAB1 | Yersinia infection |
| WP:WP4666 | 0.0341988987854 | 0.4 | TAB2 TAB1 | Hepatitis B infection |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TAB3 | EMILIN1 | 0.461 | 0.6 | bioplex (EMILIN1) bioplex_WMM |
| TAB2 | EMILIN1 | 0.436 | 0.58 | bioplex (EMILIN1) bioplex_WMM |
| UBOX5 | EMILIN1 | 0.329 | 0.519 | bioplex (EMILIN1) bioplex_WMM |
| EMILIN1 | TAB1 | 0.055 | 0.308 | bioplex (EMILIN1) bioplex_WMM |
| TAB2 | TAB1 | 0.014 | 0.137 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| UBOX5 | TAB3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| TAB3 | TAB2 | 0.008 | 0.086 | bioplex_WMM youn_WMM WMM_only |
| UBOX5 | TAB2 | 0.008 | 0.065 | bioplex_WMM WMM_only |
| TAB3 | TAB1 | 0.008 | 0.033 | bioplex_WMM youn_WMM WMM_only |
| UBOX5 | TAB1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00142 has an average edge precision of 0.243 which is ranked 5490 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBOX5 | HuMAP2_00142 HuMAP2_00347 |
| TAB2 | HuMAP2_00142 HuMAP2_00347 HuMAP2_04881 |
| TAB3 | HuMAP2_00142 HuMAP2_00347 |
| EMILIN1 | HuMAP2_00142 HuMAP2_00347 |
| TAB1 | HuMAP2_00142 HuMAP2_00347 HuMAP2_01481 HuMAP2_04653 |