hu.MAP 2.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Links
EHMT2	Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)	UniProt NCBI
EHMT1	Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)	UniProt NCBI
XAGE3	X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein)	UniProt NCBI
ZNF644	Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2)	UniProt NCBI
XAGE2	X antigen family member 2 (XAGE-2) (Cancer/testis antigen 12.2) (CT12.2) (G antigen family D member 3)	UniProt NCBI
WIZ	Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803)	UniProt NCBI
D2HGDH	D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.-)	UniProt NCBI
ZNF462	Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:643	0.000419977984057	0.25	EHMT1 EHMT2	CtBP core complex
CORUM:1194	0.000769339286093	0.25	EHMT1 EHMT2	E2F-6 complex
CORUM:642	0.00158317684197	0.25	EHMT1 EHMT2	CtBP complex
WP:WP4288	0.00321423512458	0.25	EHMT1 EHMT2	MTHFR deficiency
REAC:R-HSA-6804760	0.00761952471968	0.25	EHMT1 EHMT2	Regulation of TP53 Activity through Methylation
KEGG:00310	0.0218622840624	0.25	EHMT1 EHMT2	Lysine degradation
REAC:R-HSA-8953750	0.0248968222949	0.25	EHMT1 EHMT2	Transcriptional Regulation by E2F6
WP:WP2369	0.0269379290762	0.25	EHMT1 EHMT2	Histone Modifications
KEGG:04211	0.0394512249973	0.25	EHMT1 EHMT2	Longevity regulating pathway
CORUM:862	0.0497224828424	0.125	EHMT2	DNMT1-EHMT2 complex

Protein 1	Protein 2	Score	Precision	Evidence
WIZ	EHMT1	1.0	0.949	hein_WMM bioplex_WMM youn_WMM hein (WIZ) Malo fraction
WIZ	XAGE2	0.434	0.578	bioplex (XAGE2) bioplex_WMM
XAGE2	EHMT2	0.426	0.575	bioplex (XAGE2) bioplex_WMM
ZNF644	XAGE2	0.371	0.546	bioplex (XAGE2) bioplex_WMM
WIZ	XAGE3	0.287	0.489	bioplex (XAGE3) bioplex_WMM
XAGE2	EHMT1	0.243	0.468	bioplex (XAGE2) bioplex_WMM
ZNF644	EHMT2	0.222	0.466	hein_WMM bioplex_WMM youn_WMM hein (ZNF644)
WIZ	ZNF462	0.172	0.432	bioplex (ZNF462) bioplex_WMM
ZNF644	XAGE3	0.129	0.4	bioplex (XAGE3) bioplex_WMM
XAGE3	EHMT2	0.119	0.392	bioplex (XAGE3) bioplex_WMM
EHMT1	XAGE3	0.119	0.393	bioplex (XAGE3) bioplex_WMM
ZNF644	EHMT1	0.112	0.381	hein_WMM bioplex_WMM youn_WMM hein (ZNF644)
WIZ	EHMT2	0.094	0.358	hein_WMM bioplex_WMM youn_WMM hein (WIZ)
ZNF462	EHMT2	0.086	0.352	bioplex (ZNF462) bioplex_WMM
EHMT1	ZNF462	0.077	0.353	bioplex (ZNF462) bioplex_WMM
ZNF644	WIZ	0.049	0.295	hein_WMM bioplex_WMM youn_WMM hein (WIZ,ZNF644)
D2HGDH	ZNF462	0.032	0.243	bioplex (ZNF462) bioplex_WMM
EHMT1	EHMT2	0.028	0.233	hein_WMM bioplex_WMM youn_WMM WMM_only
ZNF644	ZNF462	0.01	0.1	bioplex (ZNF462) bioplex_WMM
WIZ	D2HGDH	0.007	0.012	bioplex_WMM WMM_only
EHMT1	D2HGDH	0.007	0.006	bioplex_WMM WMM_only
D2HGDH	EHMT2	0.007	0.006	bioplex_WMM WMM_only
ZNF644	D2HGDH	0.007	0.001	bioplex_WMM WMM_only

Click to enlarge

Complex HuMAP2_00144 has an average edge precision of 0.349 which is ranked 3977 out of all 6965 complexes.