hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00153

Confidence: Medium High

Genename	Protein Name	Links
TNRC6A	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)	UniProt NCBI
RC3H1	Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)	UniProt NCBI
RC3H2	Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)	UniProt NCBI
AGO1	Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)	UniProt NCBI
TNRC6B	Trinucleotide repeat-containing gene 6B protein	UniProt NCBI
AGO3	Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-426496	4.19788236367e-11	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Post-transcriptional silencing by small RNAs
REAC:R-HSA-8948700	8.39486242387e-11	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Competing endogenous RNAs (ceRNAs) regulate PTEN translation
REAC:R-HSA-8943723	1.51091283076e-10	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Regulation of PTEN mRNA translation
REAC:R-HSA-8934593	2.85149294827e-09	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Regulation of RUNX1 Expression and Activity
REAC:R-HSA-9022692	2.84195159633e-08	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Regulation of MECP2 expression and activity
REAC:R-HSA-2559585	4.30144390958e-08	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Oncogene Induced Senescence
REAC:R-HSA-8986944	3.4947873312e-07	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Transcriptional Regulation by MECP2
REAC:R-HSA-4086398	3.4947873312e-07	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Ca2+ pathway
REAC:R-HSA-5628897	1.88208682321e-06	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	TP53 Regulates Metabolic Genes
REAC:R-HSA-5687128	2.64682448332e-06	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	MAPK6/MAPK4 signaling
GO:1903706	3.05239502946e-06	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	regulation of hemopoiesis
REAC:R-HSA-1912408	3.17671544575e-06	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Pre-NOTCH Transcription and Translation
REAC:R-HSA-8936459	3.32075312801e-06	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
REAC:R-HSA-1912422	6.12327343665e-06	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Pre-NOTCH Expression and Processing
REAC:R-HSA-2559580	1.04049680701e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Oxidative Stress Induced Senescence
REAC:R-HSA-211000	1.42980225134e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Gene Silencing by RNA
GO:0007223	1.49273703752e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Wnt signaling pathway, calcium modulating pathway
REAC:R-HSA-6807070	1.56538396855e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	PTEN Regulation
REAC:R-HSA-3858494	1.66096625842e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Beta-catenin independent WNT signaling
REAC:R-HSA-9018519	1.86515884179e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Estrogen-dependent gene expression
GO:0030097	5.71347990532e-05	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	hemopoiesis
REAC:R-HSA-2559583	5.92853293102e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Cellular Senescence
GO:0048534	6.62287693266e-05	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	hematopoietic or lymphoid organ development
REAC:R-HSA-8939211	8.22588428607e-05	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	ESR-mediated signaling
GO:0002520	9.65521408066e-05	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	immune system development
REAC:R-HSA-8878171	0.000109298820952	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Transcriptional regulation by RUNX1
REAC:R-HSA-157118	0.000111310777199	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Signaling by NOTCH
REAC:R-HSA-1257604	0.000121788581155	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	PIP3 activates AKT signaling
REAC:R-HSA-5683057	0.000147417973059	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	MAPK family signaling cascades
REAC:R-HSA-9006931	0.000168441602421	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Signaling by Nuclear Receptors
GO:0003725	0.000216594058417	0.666666666667	RC3H1 AGO3 AGO1 RC3H2	double-stranded RNA binding
REAC:R-HSA-9006925	0.000227296904657	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Intracellular signaling by second messengers
GO:0045652	0.000352998651013	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	regulation of megakaryocyte differentiation
GO:0030219	0.000417891539136	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	megakaryocyte differentiation
REAC:R-HSA-195721	0.000438032292683	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Signaling by WNT
GO:0045974	0.000518697707158	0.5	TNRC6A AGO1 AGO3	regulation of translation, ncRNA-mediated
GO:0016442	0.000518697707158	0.5	TNRC6A AGO1 AGO3	RISC complex
GO:0031332	0.000518697707158	0.5	TNRC6A AGO1 AGO3	RNAi effector complex
GO:0040033	0.000518697707158	0.5	TNRC6A AGO1 AGO3	negative regulation of translation, ncRNA-mediated
GO:0035278	0.000518697707158	0.5	TNRC6A AGO1 AGO3	miRNA mediated inhibition of translation
REAC:R-HSA-3700989	0.000694220165361	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Transcriptional Regulation by TP53
REAC:R-HSA-426486	0.000797179114843	0.333333333333	AGO3 AGO1	Small interfering RNA (siRNA) biogenesis
MIRNA:hsa-miR-148b-3p	0.00107681663372	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	hsa-miR-148b-3p
REAC:R-HSA-2262752	0.00129372739211	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Cellular responses to stress
GO:0017148	0.00160072832698	0.666666666667	RC3H1 AGO3 AGO1 TNRC6A	negative regulation of translation
GO:0006402	0.00169595706398	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	mRNA catabolic process
GO:0034249	0.00249974066558	0.666666666667	RC3H1 AGO3 AGO1 TNRC6A	negative regulation of cellular amide metabolic process
GO:0006401	0.00259964787746	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	RNA catabolic process
REAC:R-HSA-8953897	0.00265671127538	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	Cellular responses to external stimuli
GO:0035567	0.00422920591485	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	non-canonical Wnt signaling pathway
GO:0002682	0.00511801887494	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	regulation of immune system process
GO:0035195	0.00537058982175	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	gene silencing by miRNA
MIRNA:hsa-miR-152-3p	0.00539033534279	0.5	TNRC6A TNRC6B AGO3	hsa-miR-152-3p
MIRNA:hsa-miR-130b-3p	0.0058638903911	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	hsa-miR-130b-3p
GO:0035198	0.00592798461195	0.5	RC3H1 AGO1 AGO3	miRNA binding
MIRNA:hsa-miR-652-3p	0.00595880473662	0.5	TNRC6A AGO1 AGO3	hsa-miR-652-3p
REAC:R-HSA-203927	0.0060953046166	0.333333333333	AGO3 AGO1	MicroRNA (miRNA) biogenesis
MIRNA:hsa-miR-19a-3p	0.00651992932499	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	hsa-miR-19a-3p
GO:0035194	0.006914256367	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	posttranscriptional gene silencing by RNA
GO:0016441	0.00710422530808	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	posttranscriptional gene silencing
GO:0045595	0.00725557716859	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	regulation of cell differentiation
GO:0045637	0.00790339487449	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	regulation of myeloid cell differentiation
GO:0034655	0.00795698548035	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	nucleobase-containing compound catabolic process
GO:0031047	0.00922585660771	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	gene silencing by RNA
GO:0010608	0.0111407474037	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	posttranscriptional regulation of gene expression
GO:0046700	0.0114847273282	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	heterocycle catabolic process
GO:0044270	0.0116012507947	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	cellular nitrogen compound catabolic process
GO:0061980	0.0118307664632	0.5	RC3H1 AGO1 AGO3	regulatory RNA binding
GO:2000026	0.0122208693309	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	regulation of multicellular organismal development
GO:0019439	0.0130745729411	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	aromatic compound catabolic process
MIRNA:hsa-miR-148a-3p	0.0131399381338	0.5	TNRC6A TNRC6B AGO3	hsa-miR-148a-3p
GO:1901361	0.0158586891275	0.833333333333	RC3H1 TNRC6B AGO3 AGO1 TNRC6A	organic cyclic compound catabolic process
MIRNA:hsa-miR-19b-3p	0.0159808472418	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	hsa-miR-19b-3p
GO:0036464	0.0162282633514	0.666666666667	RC3H1 AGO3 TNRC6B TNRC6A	cytoplasmic ribonucleoprotein granule
MIRNA:hsa-miR-877-5p	0.0165682145211	0.5	RC3H1 AGO1 AGO3	hsa-miR-877-5p
GO:0061014	0.0178456165824	0.5	RC3H1 TNRC6B TNRC6A	positive regulation of mRNA catabolic process
GO:0035770	0.0200896722061	0.666666666667	RC3H1 AGO3 TNRC6B TNRC6A	ribonucleoprotein granule
GO:0000956	0.0218120988519	0.666666666667	RC3H1 TNRC6B AGO1 TNRC6A	nuclear-transcribed mRNA catabolic process
MIRNA:hsa-miR-107	0.0360857076166	0.5	AGO3 AGO1 TNRC6B	hsa-miR-107
MIRNA:hsa-miR-519d-3p	0.0364157760598	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	hsa-miR-519d-3p
MIRNA:hsa-miR-20b-5p	0.0385495620595	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	hsa-miR-20b-5p
GO:0003723	0.0386338629612	1.0	AGO1 RC3H1 TNRC6B AGO3 RC3H2 TNRC6A	RNA binding
GO:0016458	0.0398596812877	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	gene silencing
MIRNA:hsa-miR-484	0.0415363405034	0.666666666667	TNRC6A RC3H2 AGO1 TNRC6B	hsa-miR-484
GO:0030099	0.0419904784701	0.666666666667	TNRC6A AGO3 AGO1 TNRC6B	myeloid cell differentiation
CORUM:7111	0.0499726005494	0.166666666667	RC3H1	NUFIP2-Roquin1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TNRC6A	AGO3	0.665	0.7	hein_WMM youn (TNRC6A) bioplex_WMM youn_WMM hein (AGO3)
TNRC6B	AGO3	0.23	0.467	hein_WMM youn (TNRC6B) bioplex_WMM youn_WMM hein (AGO3)
AGO1	TNRC6A	0.119	0.393	youn (TNRC6A) bioplex_WMM youn_WMM
RC3H1	TNRC6A	0.056	0.314	youn (TNRC6A) youn_WMM fraction
RC3H1	RC3H2	0.045	0.287	youn (RC3H2) youn_WMM
AGO1	TNRC6B	0.043	0.269	youn (TNRC6B) bioplex_WMM youn_WMM
AGO1	AGO3	0.013	0.149	bioplex_WMM youn_WMM WMM_only treiber_WMM
RC3H1	TNRC6B	0.01	0.141	youn (TNRC6B) youn_WMM
TNRC6A	TNRC6B	0.01	0.1	hein_WMM youn (TNRC6A,TNRC6B) bioplex_WMM youn_WMM gupta_WMM
RC3H2	AGO3	0.007	0.003	bioplex_WMM youn_WMM WMM_only
RC3H1	AGO3	0.007	0.002	youn_WMM WMM_only
TNRC6B	RC3H2	0.007	0.0	youn (RC3H2,TNRC6B) youn_WMM gupta_WMM
RC3H1	AGO1	0.007	0.006	youn_WMM WMM_only
TNRC6A	RC3H2	0.006	0.003	youn (RC3H2,TNRC6A) youn_WMM gupta_WMM
AGO1	RC3H2	0.006	0.003	youn_WMM WMM_only

Images

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Complex HuMAP2_00153 has an average edge precision of 0.189 which is ranked 6317 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TNRC6A	HuMAP2_00153 HuMAP2_00478 HuMAP2_01955 HuMAP2_06245
RC3H1	HuMAP2_00153 HuMAP2_00902 HuMAP2_03185
RC3H2	HuMAP2_00153 HuMAP2_00902 HuMAP2_03185 HuMAP2_06402
AGO1	HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_00976 HuMAP2_04674
TNRC6B	HuMAP2_00153 HuMAP2_00478 HuMAP2_01955
AGO3	HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_01955 HuMAP2_04784 HuMAP2_06154 HuMAP2_06245

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00153