hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00158
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GSTM3 | Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3) | UniProt NCBI |
| GSTM2 | Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) | UniProt NCBI |
| GSTM5 | Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5) | UniProt NCBI |
| GSTM4 | Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00480 | 3.82876589408e-09 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Glutathione metabolism |
| REAC:R-HSA-156590 | 4.20583105301e-09 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Glutathione conjugation |
| KEGG:00982 | 8.81194782213e-09 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 1.14817438441e-08 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:05204 | 1.56222127292e-08 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Chemical carcinogenesis |
| KEGG:01524 | 1.8591044121e-08 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Platinum drug resistance |
| KEGG:00983 | 1.8591044121e-08 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Drug metabolism - other enzymes |
| WP:WP2884 | 9.07485334875e-08 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | NRF2 pathway |
| GO:1901687 | 1.46007434692e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | glutathione derivative biosynthetic process |
| GO:1901685 | 1.46007434692e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | glutathione derivative metabolic process |
| KEGG:05418 | 1.7513076548e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Fluid shear stress and atherosclerosis |
| GO:0004364 | 1.7845353129e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | glutathione transferase activity |
| REAC:R-HSA-156580 | 2.88715120313e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Phase II - Conjugation of compounds |
| WP:WP702 | 3.88465236507e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 4.63280763538e-07 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Hepatocellular carcinoma |
| GO:0006749 | 2.73059518213e-06 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | glutathione metabolic process |
| WP:WP2882 | 2.73279260095e-06 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Nuclear Receptors Meta-Pathway |
| REAC:R-HSA-211859 | 4.47395278264e-06 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Biological oxidations |
| GO:0016765 | 5.16883395701e-06 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| GO:0045171 | 8.3202281769e-06 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | intercellular bridge |
| GO:0042178 | 1.27120391093e-05 | 0.75 | GSTM3 GSTM4 GSTM2 | xenobiotic catabolic process |
| GO:0043295 | 3.05058200216e-05 | 0.75 | GSTM3 GSTM4 GSTM2 | glutathione binding |
| KEGG:05200 | 3.47503918145e-05 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Pathways in cancer |
| GO:1900750 | 4.35775472874e-05 | 0.75 | GSTM3 GSTM4 GSTM2 | oligopeptide binding |
| GO:0006575 | 0.000396049862747 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | cellular modified amino acid metabolic process |
| GO:0044272 | 0.000564270065938 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | sulfur compound biosynthetic process |
| KEGG:01100 | 0.00203701694021 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Metabolic pathways |
| GO:0006790 | 0.00764589363264 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | sulfur compound metabolic process |
| GO:0018916 | 0.00811409485621 | 0.5 | GSTM3 GSTM2 | nitrobenzene metabolic process |
| GO:0070458 | 0.00811409485621 | 0.5 | GSTM3 GSTM2 | cellular detoxification of nitrogen compound |
| GO:0072341 | 0.0111781410126 | 0.75 | GSTM3 GSTM4 GSTM2 | modified amino acid binding |
| GO:0051186 | 0.0171677071312 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | cofactor metabolic process |
| GO:0051410 | 0.0270421395626 | 0.5 | GSTM3 GSTM2 | detoxification of nitrogen compound |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | GSTM3 GSTM4 GSTM5 GSTM2 | Metabolism |
| REAC:R-HSA-9026395 | 0.0499190562503 | 0.25 | GSTM4 | Biosynthesis of DHA-derived sulfido conjugates |
| REAC:R-HSA-9026762 | 0.0499190562503 | 0.25 | GSTM4 | Biosynthesis of maresin conjugates in tissue regeneration (MCTR) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSTM2 | GSTM4 | 1.0 | 0.949 | bioplex (GSTM2) bioplex_WMM |
| GSTM5 | GSTM4 | 1.0 | 0.949 | bioplex (GSTM5) bioplex_WMM |
| GSTM3 | GSTM5 | 0.996 | 0.927 | bioplex (GSTM5) bioplex_WMM |
| GSTM3 | GSTM4 | 0.937 | 0.85 | bioplex (GSTM3) bioplex_WMM |
| GSTM2 | GSTM5 | 0.827 | 0.774 | bioplex (GSTM2,GSTM5) bioplex_WMM |
| GSTM3 | GSTM2 | 0.448 | 0.592 | bioplex (GSTM2,GSTM3) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_00158 has an average edge precision of 0.84 which is ranked 812 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GSTM3 | HuMAP2_00158 HuMAP2_04058 |
| GSTM2 | HuMAP2_00158 HuMAP2_04058 |
| GSTM5 | HuMAP2_00158 HuMAP2_04058 |
| GSTM4 | HuMAP2_00158 HuMAP2_04058 |