hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00159
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLE3 | DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | UniProt NCBI |
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | UniProt NCBI |
| POLE2 | DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) | UniProt NCBI |
| POLE4 | DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-68952 | 6.34828734067e-12 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA replication initiation |
| REAC:R-HSA-174430 | 6.34828734067e-12 | 1.0 | POLE3 POLE2 POLE4 POLE | Telomere C-strand synthesis initiation |
| CORUM:1108 | 6.18958015715e-11 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 1.07920884791e-10 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.07920884791e-10 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA synthesome complex (17 subunits) |
| GO:0008622 | 1.2197780676e-10 | 1.0 | POLE3 POLE2 POLE4 POLE | epsilon DNA polymerase complex |
| REAC:R-HSA-5651801 | 5.42778567627e-10 | 1.0 | POLE3 POLE2 POLE4 POLE | PCNA-Dependent Long Patch Base Excision Repair |
| KEGG:03410 | 6.49825471272e-10 | 1.0 | POLE3 POLE2 POLE4 POLE | Base excision repair |
| REAC:R-HSA-174417 | 9.63670018313e-10 | 1.0 | POLE3 POLE2 POLE4 POLE | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03030 | 1.06445966033e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA replication |
| REAC:R-HSA-5696397 | 1.14722621228e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 1.14722621228e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03420 | 2.45312729563e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Nucleotide excision repair |
| REAC:R-HSA-180786 | 2.48535449387e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Extension of Telomeres |
| REAC:R-HSA-110314 | 2.48535449387e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 2.85355515963e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Termination of translesion DNA synthesis |
| REAC:R-HSA-68962 | 3.71102739972e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Activation of the pre-replicative complex |
| REAC:R-HSA-73933 | 4.74851893082e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 6.69426900073e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 9.18415798556e-09 | 1.0 | POLE3 POLE2 POLE4 POLE | Dual Incision in GG-NER |
| REAC:R-HSA-73893 | 1.61758895931e-08 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA Damage Bypass |
| WP:WP4022 | 2.27666803273e-08 | 1.0 | POLE3 POLE2 POLE4 POLE | Pyrimidine metabolism |
| GO:0042575 | 4.43999216606e-08 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA polymerase complex |
| REAC:R-HSA-6782210 | 5.76221345338e-08 | 1.0 | POLE3 POLE2 POLE4 POLE | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 6.14006351589e-08 | 1.0 | POLE3 POLE2 POLE4 POLE | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 6.14006351589e-08 | 1.0 | POLE3 POLE2 POLE4 POLE | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 1.29362225284e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 1.50884279717e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Telomere Maintenance |
| REAC:R-HSA-5696399 | 1.74986096744e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0003887 | 1.7845353129e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA-directed DNA polymerase activity |
| REAC:R-HSA-69002 | 1.83627385472e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA Replication Pre-Initiation |
| REAC:R-HSA-73884 | 2.01866015002e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Base Excision Repair |
| GO:0032201 | 4.28142101727e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 4.8601535637e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Chromosome Maintenance |
| GO:0034061 | 4.99499118682e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA polymerase activity |
| REAC:R-HSA-5696398 | 5.23569103583e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Nucleotide Excision Repair |
| GO:0006270 | 6.68560358851e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA replication initiation |
| REAC:R-HSA-69239 | 6.95938708355e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | Synthesis of DNA |
| REAC:R-HSA-69306 | 9.07725736124e-07 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA Replication |
| REAC:R-HSA-69206 | 1.03013477297e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | G1/S Transition |
| REAC:R-HSA-5693567 | 1.03013477297e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 1.23644957705e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | Homology Directed Repair |
| REAC:R-HSA-453279 | 1.69335486182e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 2.3250149843e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | S Phase |
| REAC:R-HSA-5693532 | 2.63463002689e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA Double-Strand Break Repair |
| GO:0033260 | 6.60448834702e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | nuclear DNA replication |
| GO:0044786 | 8.96024572897e-06 | 1.0 | POLE3 POLE2 POLE4 POLE | cell cycle DNA replication |
| REAC:R-HSA-73894 | 3.93749583955e-05 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA Repair |
| GO:0016779 | 0.000146105138915 | 1.0 | POLE3 POLE2 POLE4 POLE | nucleotidyltransferase activity |
| GO:0006261 | 0.000252118978237 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA-dependent DNA replication |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | POLE3 POLE2 POLE4 POLE | Cell Cycle, Mitotic |
| CORUM:6665 | 0.000457035673196 | 0.5 | POLE3 POLE4 | ATAC complex, YEATS2-linked |
| GO:0000723 | 0.000494260781771 | 1.0 | POLE3 POLE2 POLE4 POLE | telomere maintenance |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | POLE3 POLE2 POLE4 POLE | Cell Cycle |
| GO:0032200 | 0.000691429733885 | 1.0 | POLE3 POLE2 POLE4 POLE | telomere organization |
| GO:0140097 | 0.000921003798055 | 1.0 | POLE3 POLE2 POLE4 POLE | catalytic activity, acting on DNA |
| WP:WP466 | 0.00144137960059 | 0.5 | POLE POLE2 | DNA Replication |
| GO:0000082 | 0.00161006679656 | 1.0 | POLE3 POLE2 POLE4 POLE | G1/S transition of mitotic cell cycle |
| GO:0006260 | 0.00184822285327 | 1.0 | POLE3 POLE2 POLE4 POLE | DNA replication |
| GO:0044843 | 0.00203384001918 | 1.0 | POLE3 POLE2 POLE4 POLE | cell cycle G1/S phase transition |
| GO:0061695 | 0.00244665292597 | 1.0 | POLE3 POLE2 POLE4 POLE | transferase complex, transferring phosphorus-containing groups |
| WP:WP45 | 0.00326331699224 | 0.5 | POLE POLE2 | G1 to S cell cycle control |
| WP:WP2446 | 0.00623747495525 | 0.5 | POLE POLE2 | Retinoblastoma Gene in Cancer |
| GO:0060249 | 0.00629241325149 | 1.0 | POLE3 POLE2 POLE4 POLE | anatomical structure homeostasis |
| GO:0044772 | 0.0485535587519 | 1.0 | POLE3 POLE2 POLE4 POLE | mitotic cell cycle phase transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLE3 | POLE4 | 0.951 | 0.858 | bioplex_WMM Guru Malo fraction |
| POLE | POLE4 | 0.311 | 0.504 | bioplex_WMM Malo fraction |
| POLE3 | POLE | 0.27 | 0.483 | bioplex_WMM Malo fraction |
| POLE | POLE2 | 0.216 | 0.464 | bioplex (POLE,POLE2) bioplex_WMM Malo fraction |
| POLE2 | POLE4 | 0.045 | 0.285 | bioplex (POLE2) bioplex_WMM |
| POLE3 | POLE2 | 0.015 | 0.14 | bioplex (POLE2) bioplex_WMM |
Images
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Complex HuMAP2_00159 has an average edge precision of 0.456 which is ranked 2834 out of all 6965 complexes.
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