hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00172

Confidence: Medium

Genename	Protein Name	Links
EHF	ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3)	UniProt NCBI
JUP	Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)	UniProt NCBI
KRT6A	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5)	UniProt NCBI
KPRP	Keratinocyte proline-rich protein (hKPRP)	UniProt NCBI
DSG1	Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)	UniProt NCBI
DSC1	Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)	UniProt NCBI
KRT77	Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)	UniProt NCBI
KRT1	Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)	UniProt NCBI
DSP	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)	UniProt NCBI
KRT17	Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17)	UniProt NCBI
KRT5	Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6809371	1.89379981136e-16	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	Formation of the cornified envelope
REAC:R-HSA-6805567	2.28570893191e-15	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	Keratinization
GO:0070268	2.64071593973e-14	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	cornification
GO:0031424	3.88102019931e-13	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	keratinization
GO:0030216	6.78755997097e-12	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	keratinocyte differentiation
GO:0009913	2.52580697913e-11	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	epidermal cell differentiation
GO:0043588	5.20038947718e-11	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	skin development
HP:0008404	8.79173425384e-11	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Nail dystrophy
GO:0030855	9.62458614199e-11	0.909090909091	EHF KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	epithelial cell differentiation
GO:0008544	1.50378875201e-10	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	epidermis development
HP:0000982	8.61909106747e-10	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Palmoplantar keratoderma
HP:0008066	3.15256806684e-09	0.545454545455	KRT1 DSP JUP KRT5 KRT6A KRT17	Abnormal blistering of the skin
HP:0010765	1.30856661768e-08	0.454545454545	DSP KRT1 KRT17 KRT5 KRT6A	Palmar hyperkeratosis
GO:0060429	1.466379019e-08	0.909090909091	EHF KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	epithelium development
HP:0000962	2.56299406163e-08	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Hyperkeratosis
HP:0007556	3.16807133335e-08	0.454545454545	DSP KRT1 KRT17 KRT5 KRT6A	Plantar hyperkeratosis
HP:0000975	4.16733046802e-08	0.545454545455	KRT1 JUP KRT5 KRT6A DSG1 KRT17	Hyperhidrosis
REAC:R-HSA-1266738	1.37214480348e-07	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	Developmental Biology
HP:0007550	3.2022809145e-07	0.545454545455	KRT1 JUP KRT5 KRT6A DSG1 KRT17	Hypohidrosis or hyperhidrosis
HP:0025276	4.05441912023e-07	0.545454545455	KRT1 JUP KRT5 KRT6A DSG1 KRT17	Abnormality of skin adnexa physiology
HP:0011368	4.46290496486e-07	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Epidermal thickening
HP:0001597	5.41743444595e-07	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Abnormality of the nail
HP:0100872	6.1217884899e-07	0.454545454545	DSP KRT1 KRT17 KRT5 KRT6A	Abnormality of the plantar skin of foot
HP:0001072	9.03288833854e-07	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Thickened skin
GO:0001533	1.87872958426e-06	0.454545454545	JUP DSP KRT1 DSG1 DSC1	cornified envelope
GO:0009888	2.02446105108e-06	0.909090909091	EHF KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	tissue development
HP:0000972	2.78555437023e-06	0.363636363636	DSP KRT5 KRT17 KRT1	Palmoplantar hyperkeratosis
HP:0025092	6.89028290934e-06	0.363636363636	DSP KRT1 DSG1 JUP	Epidermal acanthosis
HP:0100792	7.70047716315e-06	0.272727272727	DSP DSG1 JUP	Acantholysis
HP:0001798	3.40338719812e-05	0.363636363636	KRT6A DSP KRT17 JUP	Anonychia
HP:0011124	4.58412560207e-05	0.363636363636	DSP KRT1 DSG1 JUP	Abnormality of epidermal morphology
HP:0200097	4.83055475804e-05	0.272727272727	DSP JUP KRT5	Oral mucosal blisters
HP:0100643	0.000122761464246	0.272727272727	DSP KRT17 KRT6A	Abnormality of nail color
HP:0040211	0.000125683686514	0.454545454545	DSP KRT1 KRT17 KRT5 KRT6A	Abnormality of the skin of the palm
HP:0002745	0.00021216441234	0.272727272727	KRT6A KRT17 KRT5	Oral leukoplakia
HP:0001805	0.00021216441234	0.272727272727	KRT6A KRT17 KRT5	Onychogryposis
HP:0025125	0.00021216441234	0.272727272727	KRT6A KRT17 KRT5	White lesion of the oral mucosa
HP:0011830	0.00024273188571	0.454545454545	KRT6A DSP KRT5 KRT17 JUP	Abnormal oral mucosa morphology
HP:0000695	0.000290971329512	0.272727272727	DSP KRT17 JUP	Natal tooth
GO:0012501	0.000460119204678	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	programmed cell death
HP:0100871	0.000586246489069	0.454545454545	DSP KRT1 KRT17 KRT5 KRT6A	Abnormality of the palm
HP:0011356	0.000653542543437	0.454545454545	DSP KRT1 KRT17 KRT5 KRT6A	Regional abnormality of skin
HP:0006288	0.000796830769718	0.272727272727	DSP KRT17 JUP	Advanced eruption of teeth
GO:0008219	0.000882176106947	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	cell death
HP:0011138	0.000936285748363	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Abnormality of skin adnexa morphology
HP:0008064	0.00106151406732	0.363636363636	DSP KRT1 KRT17 KRT6A	Ichthyosis
HP:0011122	0.00157727911793	0.454545454545	DSP KRT1 DSG1 KRT5 KRT17	Abnormality of skin physiology
REAC:R-HSA-6798695	0.00173943062376	0.454545454545	JUP DSP KRT1 DSG1 DSC1	Neutrophil degranulation
HP:0011355	0.00175257425127	0.545454545455	KRT1 DSP JUP KRT5 KRT6A KRT17	Localized skin lesion
HP:0004791	0.00218605690274	0.181818181818	DSP JUP	Esophageal ulceration
HP:0007475	0.00218605690274	0.181818181818	DSP KRT1	Congenital bullous ichthyosiform erythroderma
HP:0001596	0.00245637000388	0.363636363636	KRT6A DSP KRT17 JUP	Alopecia
HP:0008386	0.00258671926286	0.363636363636	KRT6A DSP KRT17 JUP	Aplasia/Hypoplasia of the nails
GO:0030154	0.00340802364642	0.909090909091	EHF KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	cell differentiation
REAC:R-HSA-351906	0.0059596653991	0.181818181818	DSP DSG1	Apoptotic cleavage of cell adhesion proteins
GO:0048869	0.00619251386185	0.909090909091	EHF KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	cellular developmental process
HP:0000535	0.00700397729925	0.272727272727	DSP KRT17 JUP	Sparse and thin eyebrow
GO:0048513	0.00784678527474	0.818181818182	KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	animal organ development
HP:0011362	0.00870891704211	0.454545454545	JUP DSP KRT6A DSG1 KRT17	Abnormal hair quantity
HP:0001595	0.00943809675895	0.545454545455	KRT1 DSP JUP KRT6A DSG1 KRT17	Abnormal hair morphology
HP:0045074	0.0098310528136	0.272727272727	DSP KRT17 JUP	Thin eyebrow
GO:0030057	0.0101325037368	0.272727272727	JUP DSG1 DSC1	desmosome
HP:0011121	0.0106735471088	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Abnormality of skin morphology
HP:0001581	0.0122543871974	0.272727272727	KRT5 DSG1 KRT1	Recurrent skin infections
HP:0200040	0.0130899397764	0.181818181818	KRT6A KRT17	Epidermoid cyst
HP:0011663	0.0130899397764	0.181818181818	DSP JUP	Right ventricular cardiomyopathy
HP:0006682	0.0163558322879	0.181818181818	DSP JUP	Ventricular extrasystoles
HP:0000951	0.0172232837122	0.636363636364	KRT1 DSP JUP KRT5 KRT6A DSG1 KRT17	Abnormality of the skin
GO:0005200	0.0199147327968	0.363636363636	DSP KRT5 KRT17 KRT6A	structural constituent of cytoskeleton
GO:0070062	0.0207146362136	0.818181818182	KRT1 KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A KPRP	extracellular exosome
HP:0045075	0.0210575189774	0.272727272727	DSP KRT17 JUP	Sparse eyebrow
GO:0005198	0.0218669121416	0.545454545455	KRT1 DSP JUP KRT5 KRT6A KRT17	structural molecule activity
GO:1903561	0.0223776247411	0.818181818182	KRT1 KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A KPRP	extracellular vesicle
GO:0043230	0.0226830022516	0.818181818182	KRT1 KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A KPRP	extracellular organelle
HP:0011123	0.0286509096947	0.363636363636	KRT1 KRT5 DSG1 KRT17	Inflammatory abnormality of the skin
GO:0007275	0.0295398167187	0.909090909091	EHF KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KRT1	multicellular organism development
HP:0010783	0.0303266085921	0.272727272727	DSP KRT1 KRT5	Erythema
HP:0001806	0.0330218557658	0.181818181818	DSG1 JUP	Onycholysis
HP:0200035	0.0330218557658	0.181818181818	KRT6A KRT17	Skin plaque
HP:0025245	0.0330218557658	0.181818181818	KRT6A KRT17	Cutaneous cyst
HP:0200041	0.043510222531	0.181818181818	DSP JUP	Skin erosion
GO:0031982	0.0464899471098	0.909090909091	KRT1 KRT17 DSP DSC1 JUP KRT5 KRT77 KRT6A DSG1 KPRP	vesicle
KEGG:05150	0.0466952529253	0.181818181818	DSG1 KRT17	Staphylococcus aureus infection
HP:0000164	0.0484657399609	0.454545454545	KRT6A DSP KRT5 KRT17 JUP	Abnormality of the dentition

Edges

Protein 1	Protein 2	Score	Precision	Evidence
DSP	JUP	0.858	0.796	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
DSP	KRT1	0.645	0.687	youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
DSP	KRT5	0.4	0.56	youn_WMM gupta_WMM fraction boldt_WMM
DSG1	DSC1	0.18	0.437	hein_WMM bioplex_WMM WMM_only boldt_WMM treiber_WMM
DSP	DSG1	0.121	0.393	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
KRT77	KRT1	0.04	0.268	youn_WMM fraction boldt_WMM
DSP	DSC1	0.037	0.268	bioplex_WMM WMM_only boldt_WMM treiber_WMM
KRT17	KRT5	0.037	0.263	youn_WMM gupta_WMM fraction boldt_WMM
KPRP	DSG1	0.034	0.264	bioplex_WMM WMM_only boldt_WMM treiber_WMM
DSP	KRT17	0.034	0.256	youn_WMM gupta_WMM fraction boldt_WMM
KPRP	EHF	0.032	0.242	bioplex (EHF) bioplex_WMM
DSG1	JUP	0.026	0.218	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
KPRP	JUP	0.025	0.215	hein_WMM bioplex_WMM WMM_only boldt_WMM treiber_WMM
KPRP	DSC1	0.024	0.214	bioplex_WMM WMM_only boldt_WMM treiber_WMM
KRT17	KRT6A	0.022	0.206	youn_WMM gupta_WMM fraction boldt_WMM
DSP	KPRP	0.02	0.185	bioplex_WMM WMM_only boldt_WMM treiber_WMM
JUP	KRT1	0.018	0.178	youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
DSC1	JUP	0.01	0.098	bioplex_WMM WMM_only boldt_WMM treiber_WMM
DSP	KRT77	0.009	0.099	youn_WMM fraction boldt_WMM
JUP	KRT5	0.009	0.096	hein_WMM youn_WMM gupta_WMM fraction boldt_WMM
KRT17	KRT77	0.009	0.092	fraction boldt_WMM
DSC1	KRT1	0.006	0.007	WMM_only boldt_WMM treiber_WMM
DSC1	KRT6A	0.006	0.006	hein_WMM WMM_only boldt_WMM
DSG1	KRT1	0.006	0.0	youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
DSC1	KRT5	0.006	0.006	WMM_only boldt_WMM
KPRP	KRT1	0.006	0.005	WMM_only boldt_WMM treiber_WMM
KPRP	KRT5	0.006	0.007	hein_WMM WMM_only boldt_WMM
DSG1	KRT5	0.006	0.004	youn_WMM gupta_WMM WMM_only boldt_WMM
DSP	KRT6A	0.006	0.005	youn_WMM gupta_WMM WMM_only boldt_WMM
DSC1	KRT77	0.006	0.007	WMM_only boldt_WMM
KRT17	DSC1	0.006	0.008	WMM_only boldt_WMM
DSG1	KRT77	0.006	0.005	youn_WMM WMM_only boldt_WMM
DSG1	KRT6A	0.006	0.011	gupta_WMM WMM_only boldt_WMM
DSG1	KRT17	0.005	0.007	gupta_WMM WMM_only boldt_WMM
DSG1	EHF	0.005	0.009	bioplex (EHF) bioplex_WMM
KPRP	KRT77	0.005	0.011	WMM_only boldt_WMM
KRT6A	KRT1	0.005	0.008	youn_WMM gupta_WMM WMM_only boldt_WMM
DSC1	EHF	0.005	0.007	bioplex (EHF) bioplex_WMM
KRT6A	KRT5	0.005	0.017	youn_WMM gupta_WMM WMM_only boldt_WMM
KPRP	KRT6A	0.005	0.008	WMM_only boldt_WMM
KPRP	KRT17	0.005	0.011	WMM_only boldt_WMM
DSP	EHF	0.004	0.012	bioplex (EHF) bioplex_WMM
EHF	JUP	0.004	0.009	bioplex (EHF) bioplex_WMM
KRT77	JUP	0.0	0.008	youn_WMM fraction boldt_WMM
JUP	KRT6A	0.0	0.008	youn_WMM gupta_WMM fraction boldt_WMM
KRT77	KRT5	0.0	0.007	youn_WMM fraction boldt_WMM
KRT17	KRT1	0.0	0.001	youn_WMM gupta_WMM fraction boldt_WMM
KRT17	JUP	0.0	0.002	youn_WMM gupta_WMM fraction boldt_WMM
KRT1	KRT5	0.0	0.001	youn_WMM gupta_WMM fraction boldt_WMM
KRT77	KRT6A	0.0	0.0	youn_WMM fraction boldt_WMM

Images

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Complex HuMAP2_00172 has an average edge precision of 0.125 which is ranked 6852 out of all 6965 complexes.

Related Complexes

Genename	Complexes
EHF	HuMAP2_00172
JUP	HuMAP2_00172 HuMAP2_01725 HuMAP2_03046 HuMAP2_05547
KRT6A	HuMAP2_00172 HuMAP2_01048 HuMAP2_01970
KPRP	HuMAP2_00172
DSG1	HuMAP2_00172 HuMAP2_05629
DSC1	HuMAP2_00172 HuMAP2_05629
KRT77	HuMAP2_00172 HuMAP2_01970 HuMAP2_04038
KRT1	HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_04038
DSP	HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_03046 HuMAP2_04038
KRT17	HuMAP2_00172 HuMAP2_01048 HuMAP2_01970
KRT5	HuMAP2_00172 HuMAP2_00512 HuMAP2_01048 HuMAP2_01970 HuMAP2_04038

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00172