hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00173
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAT2B | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | UniProt NCBI |
| MAT2A | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | UniProt NCBI |
| MAT1A | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP704 | 5.41046835882e-09 | 1.0 | MAT1A MAT2A MAT2B | Methylation Pathways |
| WP:WP3580 | 8.56657490147e-08 | 1.0 | MAT1A MAT2A MAT2B | Methionine De Novo and Salvage Pathway |
| REAC:R-HSA-156581 | 1.63653275606e-07 | 1.0 | MAT1A MAT2A MAT2B | Methylation |
| WP:WP2525 | 2.61505970677e-07 | 1.0 | MAT1A MAT2A MAT2B | Trans-sulfuration and one carbon metabolism |
| GO:0006556 | 3.63274304092e-07 | 1.0 | MAT1A MAT2A MAT2B | S-adenosylmethionine biosynthetic process |
| KEGG:00270 | 4.56498670209e-07 | 1.0 | MAT1A MAT2A MAT2B | Cysteine and methionine metabolism |
| KEGG:01230 | 1.7187866598e-06 | 1.0 | MAT1A MAT2A MAT2B | Biosynthesis of amino acids |
| CORUM:7191 | 3.35600554376e-06 | 0.666666666667 | MAT2B MAT2A | Methionine adenosyltransferase alpha2 beta-v1 |
| GO:0046500 | 1.08982291228e-05 | 1.0 | MAT1A MAT2A MAT2B | S-adenosylmethionine metabolic process |
| WP:WP4292 | 4.31484851616e-05 | 0.666666666667 | MAT1A MAT2B | Methionine metabolism leading to Sulphur Amino Acids and related disorders |
| REAC:R-HSA-156580 | 6.22309564368e-05 | 1.0 | MAT1A MAT2A MAT2B | Phase II - Conjugation of compounds |
| WP:WP241 | 0.000362155110066 | 0.666666666667 | MAT1A MAT2B | One Carbon Metabolism |
| REAC:R-HSA-211859 | 0.000482167959223 | 1.0 | MAT1A MAT2A MAT2B | Biological oxidations |
| WP:WP3940 | 0.00107974810491 | 0.666666666667 | MAT1A MAT2A | One carbon metabolism and related pathways |
| GO:0048269 | 0.00135247023414 | 0.666666666667 | MAT2B MAT2A | methionine adenosyltransferase complex |
| GO:0004478 | 0.00135247023414 | 0.666666666667 | MAT1A MAT2A | methionine adenosyltransferase activity |
| KEGG:01100 | 0.0105851300972 | 1.0 | MAT1A MAT2A MAT2B | Metabolic pathways |
| GO:0009108 | 0.0230188762788 | 1.0 | MAT1A MAT2A MAT2B | coenzyme biosynthetic process |
| CORUM:7197 | 0.0249904952816 | 0.333333333333 | MAT1A | Methionine adenosyltransferase alpha1 beta-v1 |
| MIRNA:hsa-miR-21-3p | 0.0264402587388 | 0.666666666667 | MAT2B MAT2A | hsa-miR-21-3p |
| REAC:R-HSA-5579024 | 0.0498572752401 | 0.333333333333 | MAT1A | Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAT2A | MAT1A | 0.931 | 0.846 | bioplex (MAT1A,MAT2A) bioplex_WMM |
| MAT2A | MAT2B | 0.73 | 0.735 | bioplex (MAT2A,MAT2B) bioplex_WMM youn_WMM Malo fraction boldt_WMM treiber_WMM |
| MAT1A | MAT2B | 0.072 | 0.353 | bioplex (MAT1A) bioplex_WMM fraction |
Images
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Complex HuMAP2_00173 has an average edge precision of 0.645 which is ranked 1674 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAT2B | HuMAP2_00173 HuMAP2_02607 HuMAP2_03812 HuMAP2_05216 HuMAP2_05485 |
| MAT2A | HuMAP2_00173 HuMAP2_06767 |
| MAT1A | HuMAP2_00173 |