hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00177
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUDT5 | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | UniProt NCBI |
| PYCR3 | Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 2.96966986958e-07 | 0.75 | PYCR2 PYCR3 PYCR1 | Glutamate and glutamine metabolism |
| GO:0004735 | 1.45302402969e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 1.45302402969e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | L-proline biosynthetic process |
| GO:0006561 | 3.6323771075e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | proline biosynthetic process |
| KEGG:00330 | 4.64366792489e-06 | 0.75 | PYCR2 PYCR3 PYCR1 | Arginine and proline metabolism |
| KEGG:01230 | 1.5327283042e-05 | 0.75 | PYCR2 PYCR3 PYCR1 | Biosynthesis of amino acids |
| GO:0006560 | 4.35775472874e-05 | 0.75 | PYCR2 PYCR3 PYCR1 | proline metabolic process |
| GO:0009084 | 0.000132158586819 | 0.75 | PYCR2 PYCR3 PYCR1 | glutamine family amino acid biosynthetic process |
| GO:0016646 | 0.000246852342475 | 0.75 | PYCR2 PYCR3 PYCR1 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| WP:WP497 | 0.000352218401684 | 0.5 | PYCR3 PYCR1 | Urea cycle and metabolism of amino groups |
| GO:0016645 | 0.000834605087859 | 0.75 | PYCR2 PYCR3 PYCR1 | oxidoreductase activity, acting on the CH-NH group of donors |
| WP:WP4290 | 0.00144137960059 | 0.5 | PYCR2 PYCR1 | Metabolic reprogramming in colon cancer |
| KEGG:01100 | 0.00203701694021 | 1.0 | NUDT5 PYCR1 PYCR3 PYCR2 | Metabolic pathways |
| GO:0009064 | 0.00754689803038 | 0.75 | PYCR2 PYCR3 PYCR1 | glutamine family amino acid metabolic process |
| REAC:R-HSA-71291 | 0.0093203083965 | 0.75 | PYCR2 PYCR3 PYCR1 | Metabolism of amino acids and derivatives |
| GO:1901607 | 0.0100430829723 | 0.75 | PYCR2 PYCR3 PYCR1 | alpha-amino acid biosynthetic process |
| GO:0008652 | 0.0198185309013 | 0.75 | PYCR2 PYCR3 PYCR1 | cellular amino acid biosynthetic process |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | NUDT5 PYCR1 PYCR3 PYCR2 | Metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.949 | hein_WMM bioplex (PYCR1,PYCR2) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT5 | PYCR2 | 0.992 | 0.912 | bioplex (PYCR2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NUDT5 | PYCR1 | 0.971 | 0.882 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| PYCR3 | PYCR1 | 0.251 | 0.475 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM boldt_WMM |
| PYCR3 | PYCR2 | 0.11 | 0.379 | bioplex (PYCR2) bioplex_WMM youn_WMM |
| NUDT5 | PYCR3 | 0.008 | 0.033 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_00177 has an average edge precision of 0.605 which is ranked 1914 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUDT5 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_05934 |
| PYCR3 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_06858 |
| PYCR2 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_03284 HuMAP2_05934 HuMAP2_06951 |
| PYCR1 | HuMAP2_00177 HuMAP2_00369 HuMAP2_00616 HuMAP2_05934 HuMAP2_06951 |