hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00180
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GAPVD1 | GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6) | UniProt NCBI |
| SPATA46 | Spermatogenesis-associated protein 46 | UniProt NCBI |
| SNX24 | Sorting nexin-24 | UniProt NCBI |
| FAM110B | Protein FAM110B | UniProt NCBI |
| ZNF618 | Zinc finger protein 618 | UniProt NCBI |
| LONRF2 | LON peptidase N-terminal domain and RING finger protein 2 (Neuroblastoma apoptosis-related protease) (RING finger protein 192) | UniProt NCBI |
| PER2 | Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2) | UniProt NCBI |
| CSNK1D | Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) | UniProt NCBI |
| SNX22 | Sorting nexin-22 | UniProt NCBI |
| CSNK1E | Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 3.79409258582e-05 | 0.3 | CSNK1D PER2 CSNK1E | Circadian rhythm |
| WP:WP3298 | 6.05568631308e-05 | 0.3 | CSNK1D PER2 CSNK1E | Melatonin metabolism and effects |
| HP:0031873 | 0.000881729914172 | 0.2 | CSNK1D PER2 | Early chronotype |
| REAC:R-HSA-400253 | 0.00194866452029 | 0.3 | CSNK1D PER2 CSNK1E | Circadian Clock |
| WP:WP3594 | 0.00894592911381 | 0.3 | CSNK1D PER2 CSNK1E | Circadian rhythm related genes |
| HP:0006979 | 0.0105580428902 | 0.2 | CSNK1D PER2 | Sleep-wake cycle disturbance |
| WP:WP4249 | 0.0175768464916 | 0.2 | CSNK1D CSNK1E | Hedgehog Signaling Pathway |
| KEGG:04340 | 0.0181778440105 | 0.2 | CSNK1D CSNK1E | Hedgehog signaling pathway |
| GO:1904956 | 0.020287053512 | 0.2 | CSNK1D CSNK1E | regulation of midbrain dopaminergic neuron differentiation |
| GO:1904958 | 0.020287053512 | 0.2 | CSNK1D CSNK1E | positive regulation of midbrain dopaminergic neuron differentiation |
| GO:1905424 | 0.020287053512 | 0.2 | CSNK1D CSNK1E | regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| GO:1905426 | 0.020287053512 | 0.2 | CSNK1D CSNK1E | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| MIRNA:hsa-miR-548s | 0.0237736172557 | 0.4 | ZNF618 SNX22 CSNK1E PER2 | hsa-miR-548s |
| WP:WP363 | 0.0292874377668 | 0.2 | CSNK1D CSNK1E | Wnt Signaling Pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SNX22 | SNX24 | 0.989 | 0.905 | bioplex (SNX24) bioplex_WMM |
| GAPVD1 | SNX24 | 0.987 | 0.901 | hein_WMM bioplex (SNX24) bioplex_WMM youn_WMM gupta_WMM |
| CSNK1E | CSNK1D | 0.975 | 0.887 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1D) |
| CSNK1E | GAPVD1 | 0.624 | 0.678 | hein_WMM bioplex (CSNK1E) bioplex_WMM hein (CSNK1E) |
| GAPVD1 | CSNK1D | 0.618 | 0.675 | hein_WMM bioplex (CSNK1D) bioplex_WMM youn_WMM hein (CSNK1D) gupta_WMM |
| SPATA46 | GAPVD1 | 0.558 | 0.649 | bioplex (SPATA46) bioplex_WMM |
| LONRF2 | SNX24 | 0.531 | 0.635 | bioplex (SNX24) bioplex_WMM |
| FAM110B | CSNK1D | 0.448 | 0.592 | bioplex (CSNK1D) bioplex_WMM |
| SPATA46 | SNX24 | 0.411 | 0.57 | bioplex (SPATA46) bioplex_WMM |
| CSNK1E | SNX24 | 0.242 | 0.468 | hein_WMM bioplex (CSNK1E,SNX24) bioplex_WMM hein (CSNK1E) |
| PER2 | CSNK1E | 0.136 | 0.407 | bioplex (CSNK1E) bioplex_WMM |
| PER2 | CSNK1D | 0.092 | 0.356 | bioplex (CSNK1D) bioplex_WMM |
| FAM110B | CSNK1E | 0.089 | 0.356 | bioplex (CSNK1E) bioplex_WMM |
| CSNK1D | SNX24 | 0.071 | 0.351 | hein_WMM bioplex (CSNK1D,SNX24) bioplex_WMM youn_WMM hein (CSNK1D) |
| ZNF618 | CSNK1E | 0.038 | 0.265 | bioplex (CSNK1E) bioplex_WMM |
| ZNF618 | CSNK1D | 0.028 | 0.231 | bioplex (CSNK1D) bioplex_WMM |
| SNX22 | CSNK1D | 0.017 | 0.174 | bioplex (CSNK1D) bioplex_WMM |
| SNX22 | GAPVD1 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| FAM110B | PER2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| ZNF618 | SNX24 | 0.01 | 0.129 | bioplex_WMM WMM_only |
| ZNF618 | GAPVD1 | 0.01 | 0.129 | bioplex_WMM WMM_only |
| FAM110B | ZNF618 | 0.01 | 0.106 | bioplex_WMM WMM_only |
| ZNF618 | PER2 | 0.01 | 0.106 | bioplex_WMM WMM_only |
| FAM110B | GAPVD1 | 0.009 | 0.112 | bioplex_WMM boldt boldt_WMM |
| PER2 | GAPVD1 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| PER2 | SNX24 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| FAM110B | SNX24 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| SNX22 | FAM110B | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SNX22 | PER2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SNX22 | ZNF618 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| SNX22 | LONRF2 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| LONRF2 | GAPVD1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| SNX22 | CSNK1E | 0.007 | 0.005 | bioplex_WMM WMM_only |
| LONRF2 | CSNK1D | 0.007 | 0.002 | bioplex_WMM WMM_only |
| LONRF2 | CSNK1E | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00180 has an average edge precision of 0.3 which is ranked 4600 out of all 6965 complexes.
Related Complexes