hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00183
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | UniProt NCBI |
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | UniProt NCBI |
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | UniProt NCBI |
| SETD3 | Actin-histidine N-methyltransferase (EC 2.1.1.85) (SET domain-containing protein 3) (hSETD3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0200149 | 3.27563865676e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | CSF lymphocytic pleiocytosis |
| HP:0030356 | 3.27563865676e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Increased serum interferon-gamma level |
| HP:0012229 | 3.27563865676e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | CSF pleocytosis |
| HP:0009710 | 3.27563865676e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Chilblains |
| HP:0009709 | 3.27563865676e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Increased CSF interferon alpha |
| HP:0009704 | 3.27563865676e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Chronic CSF lymphocytosis |
| HP:0040140 | 5.24049381299e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Degeneration of the striatum |
| HP:0005550 | 5.24049381299e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Chronic lymphatic leukemia |
| HP:0001955 | 5.24049381299e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Unexplained fevers |
| HP:0030355 | 7.85994870532e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal serum interferon-gamma level |
| HP:0030354 | 7.85994870532e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal serum interferon level |
| GO:0032299 | 9.08185760231e-07 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | ribonuclease H2 complex |
| HP:0007052 | 1.12273667624e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Multifocal cerebral white matter abnormalities |
| HP:0011834 | 1.12273667624e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Moyamoya phenomenon |
| HP:0004809 | 2.05793576429e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Neonatal alloimmune thrombocytopenia |
| HP:0003683 | 2.67504688957e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Large beaked nose |
| HP:0007076 | 2.67504688957e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Extrapyramidal muscular rigidity |
| HP:0011112 | 3.40426201827e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of serum cytokine level |
| HP:0011111 | 4.25489865349e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of immune serum protein physiology |
| HP:0030038 | 4.25489865349e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Enchondroma |
| HP:0005558 | 5.23627053194e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Chronic leukemia |
| HP:0004963 | 5.23627053194e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Calcification of the aorta |
| KEGG:03030 | 6.15515195207e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | DNA replication |
| HP:0030880 | 7.62845613622e-06 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Raynaud phenomenon |
| HP:0012490 | 1.06552534153e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Panniculitis |
| HP:0001063 | 1.24298757708e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Acrocyanosis |
| HP:0003207 | 1.89101201992e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Arterial calcification |
| HP:0002132 | 2.14866062081e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Porencephalic cyst |
| HP:0004934 | 2.14866062081e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Vascular calcification |
| HP:0000625 | 2.73198472697e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Eyelid coloboma |
| HP:0011915 | 2.73198472697e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Cardiovascular calcification |
| HP:0002139 | 3.41219105177e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Arrhinencephaly |
| HP:0010994 | 3.41219105177e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal corpus striatum morphology |
| HP:0025323 | 3.79094101603e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal arterial physiology |
| HP:0100614 | 3.79094101603e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Myositis |
| HP:0011226 | 4.19668994697e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Aplasia/Hypoplasia of the eyelid |
| HP:0006579 | 4.19668994697e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Prolonged neonatal jaundice |
| HP:0007108 | 5.09288575021e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Demyelinating peripheral neuropathy |
| HP:0002371 | 5.58518220376e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Loss of speech |
| HP:0001087 | 7.24995537039e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Developmental glaucoma |
| HP:0002313 | 7.87058594756e-05 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Spastic paraparesis |
| HP:0002828 | 0.000171700780036 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Multiple joint contractures |
| HP:0000961 | 0.000194037496444 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Cyanosis |
| HP:0002385 | 0.000218228311494 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Paraparesis |
| HP:0002323 | 0.000287298458388 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Anencephaly |
| HP:0001357 | 0.000302658877703 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Plagiocephaly |
| HP:0000965 | 0.000318556115604 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Cutis marmorata |
| HP:0001433 | 0.000334999316862 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hepatosplenomegaly |
| HP:0001609 | 0.000334999316862 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hoarse voice |
| HP:0010622 | 0.000387696092352 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Neoplasm of the skeletal system |
| HP:0002180 | 0.000445635390561 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Neurodegeneration |
| HP:0003552 | 0.000466156074572 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Muscle stiffness |
| HP:0001640 | 0.000509063514163 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Cardiomegaly |
| HP:0002510 | 0.000578226462924 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Spastic tetraplegia |
| HP:0100578 | 0.000627642453711 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Lipoatrophy |
| HP:0025454 | 0.00098402511782 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal CSF metabolite level |
| HP:0004942 | 0.00098402511782 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Aortic aneurysm |
| HP:0002415 | 0.00124354263601 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Leukodystrophy |
| HP:0002187 | 0.00145437147213 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Intellectual disability, profound |
| HP:0009125 | 0.00159159306632 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Lipodystrophy |
| HP:0009145 | 0.00173715466811 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal cerebral artery morphology |
| HP:0002514 | 0.00178757045499 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Cerebral calcification |
| HP:0000958 | 0.00253383203522 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Dry skin |
| HP:0001909 | 0.00266433352331 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Leukemia |
| HP:0002960 | 0.00286833354554 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Autoimmunity |
| HP:0008936 | 0.00286833354554 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Muscular hypotonia of the trunk |
| HP:0000737 | 0.00308244473231 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Irritability |
| HP:0002617 | 0.0037878464573 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Dilatation |
| HP:0030163 | 0.00431306699981 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal vascular physiology |
| HP:0000952 | 0.00478595596144 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Jaundice |
| HP:0002063 | 0.00488448031495 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Rigidity |
| HP:0002061 | 0.0061735066244 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Lower limb spasticity |
| HP:0002134 | 0.00640811720481 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of the basal ganglia |
| HP:0001369 | 0.00640811720481 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Arthritis |
| HP:0010766 | 0.00727567741272 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Ectopic calcification |
| HP:0004374 | 0.00753710429965 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hemiplegia/hemiparesis |
| HP:0009124 | 0.00780468270807 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal adipose tissue morphology |
| HP:0000054 | 0.00864502491522 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Micropenis |
| HP:0011119 | 0.00879065778809 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of the nasal dorsum |
| HP:0010551 | 0.0089379069678 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Paraplegia/paraparesis |
| HP:0002355 | 0.0090867811499 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Difficulty walking |
| HP:0011400 | 0.0090867811499 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal CNS myelination |
| HP:0002910 | 0.0103373169418 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Elevated hepatic transaminase |
| HP:0001396 | 0.0105012068371 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Cholestasis |
| HP:0001005 | 0.0111739705033 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Dermatological manifestations of systemic disorders |
| HP:0003819 | 0.011725460578 | 0.4 | RNASEH2C RNASEH2A | Death in childhood |
| HP:0001679 | 0.0124188738287 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal aortic morphology |
| HP:0002071 | 0.0131698060475 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of extrapyramidal motor function |
| HP:0000821 | 0.0131698060475 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hypothyroidism |
| HP:0007700 | 0.0135562849022 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Ocular anterior segment dysgenesis |
| HP:0004377 | 0.01395019732 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hematological neoplasm |
| HP:0002926 | 0.0145551542008 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of thyroid physiology |
| HP:0001639 | 0.0156015562715 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hypertrophic cardiomyopathy |
| HP:0100659 | 0.0160336662282 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of the cerebral vasculature |
| HP:0001945 | 0.0164736212267 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Fever |
| HP:0002315 | 0.0197787034757 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Headache |
| HP:0000501 | 0.023494903838 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Glaucoma |
| HP:0001873 | 0.0258119768497 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Thrombocytopenia |
| HP:0002376 | 0.0261117985092 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Developmental regression |
| HP:0004297 | 0.0282751952306 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of the biliary system |
| HP:0011873 | 0.0308888583123 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal platelet count |
| HP:0004370 | 0.0343740256644 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of temperature regulation |
| HP:0000820 | 0.0365846413997 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormality of the thyroid gland |
| HP:0007256 | 0.0404739521804 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal pyramidal sign |
| HP:0001872 | 0.0421029548475 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Abnormal thrombocyte morphology |
| HP:0000819 | 0.0441992691151 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Diabetes mellitus |
| HP:0004302 | 0.0459250116542 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Functional motor deficit |
| HP:0001952 | 0.0476946051304 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Glucose intolerance |
| HP:0002079 | 0.0485960101036 | 0.6 | RNASEH2B RNASEH2C RNASEH2A | Hypoplasia of the corpus callosum |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A) fraction |
| RNASEH2B | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A,RNASEH2B) fraction |
| RNASEH2C | RNASEH2B | 1.0 | 0.949 | hein_WMM hein (RNASEH2B) fraction |
| CMTR1 | SETD3 | 0.148 | 0.409 | fraction |
| SETD3 | RNASEH2A | 0.108 | 0.373 | fraction |
| RNASEH2B | SETD3 | 0.064 | 0.349 | fraction |
| CMTR1 | RNASEH2A | 0.041 | 0.27 | youn_WMM fraction |
| RNASEH2C | CMTR1 | 0.017 | 0.172 | fraction |
| RNASEH2C | SETD3 | 0.013 | 0.142 | fraction |
| RNASEH2B | CMTR1 | 0.004 | 0.013 | fraction |
Images
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Complex HuMAP2_00183 has an average edge precision of 0.458 which is ranked 2818 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CMTR1 | HuMAP2_00183 HuMAP2_01825 HuMAP2_03593 HuMAP2_05586 |
| RNASEH2A | HuMAP2_00183 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_04588 HuMAP2_05586 |
| RNASEH2C | HuMAP2_00183 HuMAP2_00457 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_04588 |
| RNASEH2B | HuMAP2_00183 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_05586 |
| SETD3 | HuMAP2_00183 HuMAP2_01825 HuMAP2_03593 HuMAP2_05586 |