hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00185
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IFIH1 | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) | UniProt NCBI |
| RMDN1 | Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) | UniProt NCBI |
| MPZL1 | Myelin protein zero-like protein 1 (Protein zero-related) | UniProt NCBI |
| ALDH2 | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | UniProt NCBI |
| LGMN | Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1) | UniProt NCBI |
| ALDH1A2 | Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) | UniProt NCBI |
| IGHG4 | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3996 | 0.00225807155598 | 0.333333333333 | ALDH2 ALDH1A2 | Ethanol effects on histone modifications |
| WP:WP465 | 0.00390360990759 | 0.333333333333 | ALDH2 ALDH1A2 | Tryptophan metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH2 | ALDH1A2 | 0.292 | 0.493 | bioplex (ALDH2) bioplex_WMM |
| ALDH2 | IGHG4 | 0.106 | 0.374 | bioplex (ALDH2) bioplex_WMM |
| ALDH2 | LGMN | 0.04 | 0.268 | bioplex (LGMN) bioplex_WMM fraction |
| MPZL1 | ALDH1A2 | 0.031 | 0.241 | bioplex (MPZL1) bioplex_WMM gupta_WMM |
| ALDH2 | RMDN1 | 0.026 | 0.219 | fraction |
| IFIH1 | MPZL1 | 0.023 | 0.21 | bioplex (MPZL1) bioplex_WMM |
| IGHG4 | ALDH1A2 | 0.008 | 0.034 | bioplex_WMM WMM_only |
| IFIH1 | ALDH1A2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| LGMN | ALDH1A2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| ALDH2 | MPZL1 | 0.006 | 0.004 | bioplex (MPZL1) |
| RMDN1 | LGMN | 0.004 | 0.011 | fraction |
Images
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Complex HuMAP2_00185 has an average edge precision of 0.17 which is ranked 6528 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IFIH1 | HuMAP2_00185 HuMAP2_06432 |
| RMDN1 | HuMAP2_00185 HuMAP2_01460 HuMAP2_05485 |
| MPZL1 | HuMAP2_00185 HuMAP2_06432 |
| ALDH2 | HuMAP2_00148 HuMAP2_00185 HuMAP2_00305 HuMAP2_01176 HuMAP2_02517 HuMAP2_04645 HuMAP2_06263 HuMAP2_06518 HuMAP2_06788 |
| LGMN | HuMAP2_00185 HuMAP2_06242 |
| ALDH1A2 | HuMAP2_00185 HuMAP2_06263 HuMAP2_06432 |
| IGHG4 | HuMAP2_00185 HuMAP2_06263 |