hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00188
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFYB | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | UniProt NCBI |
| NFYA | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | UniProt NCBI |
| NFYC | Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4478 | 2.25356268047e-10 | 1.0 | NFYC NFYA NFYB | CBF-DNA complex |
| CORUM:4498 | 9.0142507219e-10 | 1.0 | NFYC NFYA NFYB | p32-CBF-DNA complex |
| REAC:R-HSA-381183 | 3.77661405245e-08 | 1.0 | NFYC NFYA NFYB | ATF6 (ATF6-alpha) activates chaperone genes |
| REAC:R-HSA-381033 | 7.41834903159e-08 | 1.0 | NFYC NFYA NFYB | ATF6 (ATF6-alpha) activates chaperones |
| REAC:R-HSA-9614657 | 2.04566594508e-07 | 1.0 | NFYC NFYA NFYB | FOXO-mediated transcription of cell death genes |
| GO:0016602 | 3.63274304092e-07 | 1.0 | NFYC NFYA NFYB | CCAAT-binding factor complex |
| KEGG:04612 | 7.45915218436e-07 | 1.0 | NFYC NFYA NFYB | Antigen processing and presentation |
| REAC:R-HSA-380994 | 9.09984147875e-07 | 1.0 | NFYC NFYA NFYB | ATF4 activates genes in response to endoplasmic reticulum stress |
| REAC:R-HSA-381042 | 1.64282711281e-06 | 1.0 | NFYC NFYA NFYB | PERK regulates gene expression |
| REAC:R-HSA-2426168 | 3.79279954124e-06 | 1.0 | NFYC NFYA NFYB | Activation of gene expression by SREBF (SREBP) |
| REAC:R-HSA-1655829 | 8.81209945571e-06 | 1.0 | NFYC NFYA NFYB | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| REAC:R-HSA-9614085 | 1.3872762286e-05 | 1.0 | NFYC NFYA NFYB | FOXO-mediated transcription |
| KEGG:05152 | 1.65789009806e-05 | 1.0 | NFYC NFYA NFYB | Tuberculosis |
| REAC:R-HSA-381119 | 4.13094137801e-05 | 1.0 | NFYC NFYA NFYB | Unfolded Protein Response (UPR) |
| REAC:R-HSA-1989781 | 8.67362360712e-05 | 1.0 | NFYC NFYA NFYB | PPARA activates gene expression |
| REAC:R-HSA-400206 | 8.92382428809e-05 | 1.0 | NFYC NFYA NFYB | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| REAC:R-HSA-8957322 | 0.000146343794532 | 1.0 | NFYC NFYA NFYB | Metabolism of steroids |
| GO:0045540 | 0.000829990966275 | 1.0 | NFYC NFYA NFYB | regulation of cholesterol biosynthetic process |
| GO:0106118 | 0.000829990966275 | 1.0 | NFYC NFYA NFYB | regulation of sterol biosynthetic process |
| GO:0090181 | 0.0015707980909 | 1.0 | NFYC NFYA NFYB | regulation of cholesterol metabolic process |
| GO:1902930 | 0.00251749092736 | 1.0 | NFYC NFYA NFYB | regulation of alcohol biosynthetic process |
| GO:0006695 | 0.00251749092736 | 1.0 | NFYC NFYA NFYB | cholesterol biosynthetic process |
| GO:1902653 | 0.00280229798177 | 1.0 | NFYC NFYA NFYB | secondary alcohol biosynthetic process |
| GO:0016126 | 0.00295242108794 | 1.0 | NFYC NFYA NFYB | sterol biosynthetic process |
| GO:0050810 | 0.00378386515143 | 1.0 | NFYC NFYA NFYB | regulation of steroid biosynthetic process |
| GO:0000980 | 0.00435066388439 | 1.0 | NFYC NFYA NFYB | RNA polymerase II distal enhancer sequence-specific DNA binding |
| GO:0001158 | 0.00664337883609 | 1.0 | NFYC NFYA NFYB | enhancer sequence-specific DNA binding |
| GO:0019218 | 0.00804289309261 | 1.0 | NFYC NFYA NFYB | regulation of steroid metabolic process |
| GO:0035326 | 0.00962631496557 | 1.0 | NFYC NFYA NFYB | enhancer binding |
| GO:0008203 | 0.0117851633362 | 1.0 | NFYC NFYA NFYB | cholesterol metabolic process |
| GO:1902652 | 0.0151349156943 | 1.0 | NFYC NFYA NFYB | secondary alcohol metabolic process |
| GO:0016125 | 0.0170248502613 | 1.0 | NFYC NFYA NFYB | sterol metabolic process |
| REAC:R-HSA-556833 | 0.0194595609558 | 1.0 | NFYC NFYA NFYB | Metabolism of lipids |
| GO:0046165 | 0.0230188762788 | 1.0 | NFYC NFYA NFYB | alcohol biosynthetic process |
| GO:0046890 | 0.0340260876928 | 1.0 | NFYC NFYA NFYB | regulation of lipid biosynthetic process |
| GO:0006694 | 0.0372392489125 | 1.0 | NFYC NFYA NFYB | steroid biosynthetic process |
| GO:0032993 | 0.0380729634404 | 1.0 | NFYC NFYA NFYB | protein-DNA complex |
| GO:0090575 | 0.0461431021058 | 1.0 | NFYC NFYA NFYB | RNA polymerase II transcription factor complex |
| CORUM:6091 | 0.0499776345577 | 0.333333333333 | NFYA | NF-YA-LaminA complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFYB | NFYC | 1.0 | 0.949 | hein_WMM bioplex (NFYC) bioplex_WMM Guru hein (NFYB,NFYC) Malo fraction |
| NFYA | NFYC | 0.602 | 0.67 | hein_WMM bioplex (NFYA,NFYC) bioplex_WMM Guru hein (NFYA,NFYC) fraction |
| NFYA | NFYB | 0.228 | 0.468 | hein_WMM bioplex_WMM Guru hein (NFYA,NFYB) fraction |
Images
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Complex HuMAP2_00188 has an average edge precision of 0.696 which is ranked 1391 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFYB | HuMAP2_00188 HuMAP2_01706 HuMAP2_01774 HuMAP2_04445 HuMAP2_05672 HuMAP2_06896 |
| NFYA | HuMAP2_00188 HuMAP2_05672 HuMAP2_06480 HuMAP2_06896 |
| NFYC | HuMAP2_00188 HuMAP2_01774 HuMAP2_05672 HuMAP2_06896 |