hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00191
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MCM2 | DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28) | UniProt NCBI |
| MCM7 | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | UniProt NCBI |
| MCM5 | DNA replication licensing factor MCM5 (EC 3.6.4.12) (CDC46 homolog) (P1-CDC46) | UniProt NCBI |
| MCM4 | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | UniProt NCBI |
| MCMBP | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) | UniProt NCBI |
| MCM10 | Protein MCM10 homolog (HsMCM10) | UniProt NCBI |
| MCM6 | DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM) | UniProt NCBI |
| MCM3 | DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:387 | 8.55866679422e-20 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | MCM complex |
| GO:0042555 | 9.83152848673e-18 | 0.875 | MCM5 MCM7 MCM2 MCMBP MCM6 MCM3 MCM4 | MCM complex |
| REAC:R-HSA-68962 | 1.87821946849e-16 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Activation of the pre-replicative complex |
| REAC:R-HSA-176974 | 3.02658332736e-16 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Unwinding of DNA |
| WP:WP466 | 3.38366423157e-16 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | DNA Replication |
| REAC:R-HSA-176187 | 4.52537114238e-16 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Activation of ATR in response to replication stress |
| GO:0036388 | 6.46960706472e-16 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | pre-replicative complex assembly |
| GO:0006267 | 6.46960706472e-16 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication |
| GO:1902299 | 6.46960706472e-16 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | pre-replicative complex assembly involved in cell cycle DNA replication |
| GO:0003688 | 4.29334676513e-15 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | DNA replication origin binding |
| GO:0000727 | 4.267974068e-14 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | double-strand break repair via break-induced replication |
| KEGG:03030 | 1.7251926029e-13 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | DNA replication |
| REAC:R-HSA-69002 | 2.16341831328e-13 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69190 | 2.96141870184e-13 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | DNA strand elongation |
| GO:0006261 | 1.11797816292e-12 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | DNA-dependent DNA replication |
| CORUM:2792 | 1.58119379133e-12 | 0.5 | MCM6 MCM4 MCM7 MCM2 | MCM2-MCM4-MCM6-MCM7 complex |
| REAC:R-HSA-69306 | 3.69172534431e-12 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | DNA Replication |
| REAC:R-HSA-69206 | 4.61787041642e-12 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | G1/S Transition |
| WP:WP45 | 6.31507755221e-12 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | G1 to S cell cycle control |
| REAC:R-HSA-453279 | 1.11173070382e-11 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69481 | 2.76007703339e-11 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | G2/M Checkpoints |
| REAC:R-HSA-68867 | 3.56208141915e-11 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Assembly of the pre-replicative complex |
| WP:WP4352 | 4.2899890769e-11 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Ciliary landscape |
| REAC:R-HSA-68949 | 4.65934508627e-11 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Orc1 removal from chromatin |
| GO:0006270 | 5.47331906216e-11 | 0.75 | MCM5 MCM7 MCM10 MCM2 MCM3 MCM4 | DNA replication initiation |
| GO:0006260 | 6.3244708037e-11 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | DNA replication |
| GO:0003697 | 1.36501362609e-10 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | single-stranded DNA binding |
| REAC:R-HSA-69052 | 1.88658517375e-10 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Switching of origins to a post-replicative state |
| WP:WP179 | 2.74095873617e-10 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Cell Cycle |
| KEGG:04110 | 3.20403003161e-10 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Cell cycle |
| REAC:R-HSA-69239 | 1.06619478662e-09 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | Synthesis of DNA |
| REAC:R-HSA-69620 | 1.28023611064e-09 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Cell Cycle Checkpoints |
| GO:0033260 | 1.87185712979e-09 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | nuclear DNA replication |
| GO:0044786 | 2.98392077018e-09 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | cell cycle DNA replication |
| CORUM:1452 | 4.70911134935e-09 | 0.375 | MCM6 MCM7 MCM2 | MCM2-MCM6-MCM7 complex |
| CORUM:2791 | 4.70911134935e-09 | 0.375 | MCM6 MCM7 MCM4 | MCM4-MCM6-MCM7 complex |
| MIRNA:hsa-miR-34a-5p | 5.83150957429e-09 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | hsa-miR-34a-5p |
| REAC:R-HSA-69242 | 6.56893046027e-09 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | S Phase |
| GO:0000082 | 2.9047829105e-08 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | G1/S transition of mitotic cell cycle |
| GO:0044843 | 4.38227548989e-08 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | cell cycle G1/S phase transition |
| REAC:R-HSA-69278 | 7.92412271099e-08 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 2.8026585119e-07 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | Cell Cycle |
| GO:0000784 | 3.00666929825e-07 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | nuclear chromosome, telomeric region |
| GO:0000724 | 3.68653718824e-07 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | double-strand break repair via homologous recombination |
| GO:0000725 | 3.68653718824e-07 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | recombinational repair |
| GO:1902969 | 5.62690127955e-07 | 0.5 | MCM6 MCM4 MCM2 MCM3 | mitotic DNA replication |
| GO:0000781 | 8.17359506177e-07 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | chromosome, telomeric region |
| CORUM:5611 | 1.34341746381e-06 | 0.375 | MCM6 MCM2 MCM4 | Emerin complex 24 |
| GO:0043138 | 1.70572610517e-06 | 0.5 | MCM5 MCM2 MCM7 MCM6 | 3'-5' DNA helicase activity |
| GO:0006268 | 1.70572610517e-06 | 0.5 | MCM6 MCM4 MCM7 MCM2 | DNA unwinding involved in DNA replication |
| GO:0003678 | 1.90410427765e-06 | 0.625 | MCM5 MCM2 MCM4 MCM7 MCM6 | DNA helicase activity |
| WP:WP2446 | 3.7791494928e-06 | 0.5 | MCM6 MCM4 MCM7 MCM3 | Retinoblastoma Gene in Cancer |
| GO:0017116 | 4.0529570264e-06 | 0.5 | MCM5 MCM2 MCM7 MCM6 | single-stranded DNA helicase activity |
| GO:0065004 | 5.28764207876e-06 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | protein-DNA complex assembly |
| GO:0006310 | 8.64862247595e-06 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | DNA recombination |
| GO:0044454 | 1.10392724341e-05 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | nuclear chromosome part |
| GO:0044772 | 1.1436950369e-05 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | mitotic cell cycle phase transition |
| GO:0000228 | 1.36661264361e-05 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | nuclear chromosome |
| GO:0006302 | 1.68892344458e-05 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | double-strand break repair |
| GO:0044770 | 1.79181333451e-05 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | cell cycle phase transition |
| GO:0004386 | 1.98752739757e-05 | 0.625 | MCM5 MCM2 MCM4 MCM7 MCM6 | helicase activity |
| GO:0071824 | 2.02568459214e-05 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | protein-DNA complex subunit organization |
| GO:1902975 | 2.03382379613e-05 | 0.375 | MCM3 MCM2 MCM4 | mitotic DNA replication initiation |
| GO:1902292 | 2.03382379613e-05 | 0.375 | MCM3 MCM2 MCM4 | cell cycle DNA replication initiation |
| GO:1902315 | 2.03382379613e-05 | 0.375 | MCM3 MCM2 MCM4 | nuclear cell cycle DNA replication initiation |
| GO:0008094 | 2.2231978952e-05 | 0.625 | MCM5 MCM2 MCM4 MCM7 MCM6 | DNA-dependent ATPase activity |
| GO:0022402 | 4.16752355471e-05 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | cell cycle process |
| GO:0098687 | 4.87523213824e-05 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | chromosomal region |
| GO:1990837 | 5.85041874845e-05 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | sequence-specific double-stranded DNA binding |
| GO:0044427 | 0.000101191516069 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | chromosomal part |
| GO:0005694 | 0.00013521994769 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | chromosome |
| GO:0003690 | 0.000137614128613 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | double-stranded DNA binding |
| GO:0007049 | 0.000165146943803 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | cell cycle |
| MIRNA:hsa-miR-193b-3p | 0.000195279655517 | 0.75 | MCM5 MCM7 MCM10 MCM6 MCM3 MCM4 | hsa-miR-193b-3p |
| GO:0006259 | 0.000210601211554 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | DNA metabolic process |
| GO:0006974 | 0.000212679246578 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | cellular response to DNA damage stimulus |
| GO:1903047 | 0.000216887976765 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | mitotic cell cycle process |
| MIRNA:hsa-miR-1-3p | 0.000237050282163 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | hsa-miR-1-3p |
| GO:0043565 | 0.000367471367111 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | sequence-specific DNA binding |
| GO:0032508 | 0.000457563898772 | 0.5 | MCM6 MCM4 MCM7 MCM2 | DNA duplex unwinding |
| GO:0140097 | 0.000575569112274 | 0.625 | MCM5 MCM2 MCM4 MCM7 MCM6 | catalytic activity, acting on DNA |
| GO:0000278 | 0.00063078166759 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | mitotic cell cycle |
| GO:0032392 | 0.000940808399683 | 0.5 | MCM6 MCM4 MCM7 MCM2 | DNA geometric change |
| GO:0006281 | 0.00104579737157 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | DNA repair |
| GO:0042623 | 0.00147220946451 | 0.625 | MCM5 MCM2 MCM4 MCM7 MCM6 | ATPase activity, coupled |
| TF:M00739_1 | 0.00203042037791 | 0.875 | MCM5 MCM7 MCM2 MCMBP MCM6 MCM3 MCM4 | Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 |
| GO:0006271 | 0.00344619549436 | 0.375 | MCM3 MCM7 MCM4 | DNA strand elongation involved in DNA replication |
| TF:M00431_1 | 0.00364108324633 | 1.0 | MCM5 MCM7 MCM10 MCM2 MCMBP MCM6 MCM3 MCM4 | Factor: E2F-1; motif: TTTSGCGS; match class: 1 |
| GO:0022616 | 0.0102394198288 | 0.375 | MCM3 MCM7 MCM4 | DNA strand elongation |
| GO:0016887 | 0.0107256534277 | 0.625 | MCM5 MCM2 MCM4 MCM7 MCM6 | ATPase activity |
| GO:0003677 | 0.01150474629 | 0.875 | MCM5 MCM7 MCM10 MCM2 MCM6 MCM3 MCM4 | DNA binding |
| GO:1990518 | 0.0378589948753 | 0.25 | MCM6 MCM7 | single-stranded 3'-5' DNA helicase activity |
| GO:0034622 | 0.0424653981371 | 0.75 | MCM5 MCM7 MCM2 MCM6 MCM3 MCM4 | cellular protein-containing complex assembly |
| CORUM:6261 | 0.0497224828424 | 0.125 | MCM2 | Histone-2-Histone-4-ASF1-MCM2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCM6 | MCM2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (MCM2,MCM6) Malo fraction boldt_WMM treiber_WMM |
| MCM6 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM7 | MCM3 | 1.0 | 0.949 | hein_WMM bioplex (MCM3,MCM7) bioplex_WMM Guru boldt hein (MCM3) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM5 | MCM3 | 1.0 | 0.949 | hein_WMM bioplex (MCM3) bioplex_WMM Guru youn_WMM hein (MCM3) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM2 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (MCM2) Malo fraction boldt_WMM treiber_WMM |
| MCM2 | MCM3 | 1.0 | 0.949 | hein_WMM bioplex (MCM3) bioplex_WMM Guru boldt hein (MCM2,MCM3) Malo fraction boldt_WMM treiber_WMM |
| MCM7 | MCM2 | 1.0 | 0.949 | hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt hein (MCM2) Malo fraction boldt_WMM treiber_WMM |
| MCM3 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex (MCM3) bioplex_WMM Guru boldt hein (MCM3) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM5 | MCM2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (MCM2) Malo fraction boldt_WMM treiber_WMM |
| MCM7 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM6 | MCM3 | 1.0 | 0.949 | hein_WMM bioplex (MCM3) bioplex_WMM Guru boldt youn_WMM hein (MCM3,MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM6 | MCM7 | 1.0 | 0.949 | hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt hein (MCM6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM3 | MCMBP | 1.0 | 0.949 | hein_WMM bioplex (MCM3) bioplex_WMM Guru youn_WMM hein (MCM3) Malo gupta_WMM fraction treiber_WMM |
| MCM5 | MCMBP | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| MCM6 | MCMBP | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (MCM6) Malo gupta_WMM fraction treiber_WMM |
| MCM5 | MCM6 | 0.998 | 0.94 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM5 | MCM4 | 0.997 | 0.934 | hein_WMM bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM5 | MCM7 | 0.997 | 0.933 | hein_WMM bioplex (MCM7) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM7 | MCMBP | 0.712 | 0.728 | hein_WMM bioplex (MCM7) bioplex_WMM Guru Malo gupta_WMM fraction treiber_WMM |
| MCM6 | MCM10 | 0.617 | 0.675 | hein_WMM bioplex (MCM10) bioplex_WMM youn_WMM hein (MCM6) |
| MCM4 | MCM10 | 0.015 | 0.146 | hein_WMM bioplex (MCM10) bioplex_WMM gupta_WMM |
| MCM2 | MCMBP | 0.009 | 0.097 | hein_WMM bioplex_WMM WMM_only treiber_WMM |
| MCM4 | MCMBP | 0.009 | 0.093 | hein_WMM bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| MCM5 | MCM10 | 0.007 | 0.004 | youn_WMM gupta_WMM WMM_only |
| MCM3 | MCM10 | 0.007 | 0.002 | hein_WMM youn_WMM gupta_WMM WMM_only |
| MCMBP | MCM10 | 0.0 | 0.018 | hein_WMM bioplex (MCM10) bioplex_WMM youn_WMM |
| MCM7 | MCM10 | 0.0 | 0.011 | hein_WMM bioplex (MCM10) bioplex_WMM gupta_WMM |
| MCM2 | MCM10 | 0.0 | 0.002 | hein_WMM bioplex (MCM10) bioplex_WMM |
Images
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Complex HuMAP2_00191 has an average edge precision of 0.672 which is ranked 1504 out of all 6965 complexes.
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