hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00197
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMN1 | Survival motor neuron protein (Component of gems 1) (Gemin-1) | UniProt NCBI |
| SNRNP70 | U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) | UniProt NCBI |
| DDX20 | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | UniProt NCBI |
| GEMIN2 | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | UniProt NCBI |
| GEMIN4 | Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) | UniProt NCBI |
| SNRPC | U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:824 | 5.40532307664e-09 | 0.6 | GEMIN2 GEMIN4 DDX20 | Anti-SMN protein complex |
| CORUM:3284 | 5.40532307664e-09 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) |
| CORUM:832 | 2.70211703843e-08 | 0.6 | GEMIN2 GEMIN4 DDX20 | Anti-Sm protein complex |
| CORUM:1752 | 2.70211703843e-08 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN complex |
| CORUM:1751 | 1.13454616729e-07 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN complex |
| GO:0120114 | 1.31961833602e-07 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | Sm-like protein family complex |
| CORUM:1749 | 1.62061692851e-07 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN-PolII-RHA complex |
| CORUM:1745 | 6.14174359209e-07 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN complex |
| CORUM:1143 | 6.14174359209e-07 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN complex |
| GO:0000387 | 8.98734431525e-06 | 0.8 | DDX20 GEMIN2 GEMIN4 SNRPC | spliceosomal snRNP assembly |
| CORUM:3296 | 2.0123342217e-05 | 0.4 | DDX20 GEMIN4 | SMN complex (GEMIN5,4,3), SMN-independent intermediate |
| REAC:R-HSA-8953854 | 2.37148320446e-05 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | Metabolism of RNA |
| CORUM:1750 | 4.0241279111e-05 | 0.4 | DDX20 GEMIN4 | PPP4C-PPP4R2-Gemin3-Gemin4 complex |
| REAC:R-HSA-194441 | 5.30427262701e-05 | 0.6 | GEMIN2 GEMIN4 DDX20 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 5.30427262701e-05 | 0.6 | GEMIN2 GEMIN4 DDX20 | snRNP Assembly |
| CORUM:1746 | 0.000140787732431 | 0.4 | GEMIN2 GEMIN4 | SMN containing complex |
| GO:0032797 | 0.000149729915117 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN complex |
| GO:0000398 | 0.000195429782732 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | mRNA splicing, via spliceosome |
| GO:0000377 | 0.000195429782732 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.000205071070663 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | RNA splicing, via transesterification reactions |
| CORUM:1142 | 0.000241285563976 | 0.4 | GEMIN2 DDX20 | SMN complex |
| GO:0008380 | 0.000460710313953 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | RNA splicing |
| KEGG:03013 | 0.000498609547209 | 0.6 | GEMIN2 GEMIN4 DDX20 | RNA transport |
| GO:0034719 | 0.000616695699567 | 0.6 | GEMIN2 GEMIN4 DDX20 | SMN-Sm protein complex |
| GO:0006397 | 0.00066476318296 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | mRNA processing |
| GO:0022618 | 0.00719806897192 | 0.8 | DDX20 GEMIN2 GEMIN4 SNRPC | ribonucleoprotein complex assembly |
| GO:0071826 | 0.00949806952278 | 0.8 | DDX20 GEMIN2 GEMIN4 SNRPC | ribonucleoprotein complex subunit organization |
| HPA:046010_03 | 0.0113397278716 | 0.6 | SNRPC GEMIN4 SNRNP70 | smooth muscle; smooth muscle cells[Uncertain,High] |
| GO:0016071 | 0.0124036237668 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | mRNA metabolic process |
| HPA:050020_03 | 0.0165184888819 | 0.6 | SNRPC GEMIN4 SNRNP70 | spleen; cells in white pulp[Uncertain,High] |
| HPA:050010_03 | 0.0166647100634 | 0.6 | SNRPC GEMIN4 SNRNP70 | spleen; cells in red pulp[Uncertain,High] |
| HPA:011030_03 | 0.0168117813986 | 0.6 | SNRPC GEMIN4 SNRNP70 | colon; peripheral nerve/ganglion[Uncertain,High] |
| GO:0006396 | 0.0184779947673 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | RNA processing |
| HPA:004030_03 | 0.0249166933231 | 0.6 | SNRPC GEMIN4 SNRNP70 | breast; myoepithelial cells[Uncertain,High] |
| WP:WP411 | 0.0254557044772 | 0.4 | DDX20 SNRNP70 | mRNA Processing |
| KEGG:03040 | 0.0353865382697 | 0.4 | SNRPC SNRNP70 | Spliceosome |
| GO:0030532 | 0.0358473364726 | 0.6 | SNRPC GEMIN4 SNRNP70 | small nuclear ribonucleoprotein complex |
| HPA:056010_03 | 0.044874290122 | 0.6 | SNRPC GEMIN4 SNRNP70 | tonsil; germinal center cells[Uncertain,High] |
| CORUM:0000000 | 0.0474603483533 | 1.0 | DDX20 GEMIN2 SNRNP70 GEMIN4 SNRPC | CORUM root |
| CORUM:3298 | 0.0499494897235 | 0.2 | GEMIN2 | SMN complex (GEMIN2,5, SMN) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GEMIN4 | DDX20 | 0.997 | 0.93 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM treiber_WMM |
| DDX20 | SNRNP70 | 0.977 | 0.893 | hein_WMM youn (DDX20) bioplex (DDX20,SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) treiber_WMM |
| GEMIN4 | SNRNP70 | 0.888 | 0.818 | hein_WMM bioplex (SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) treiber_WMM |
| GEMIN2 | SNRNP70 | 0.816 | 0.773 | hein_WMM bioplex (GEMIN2,SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) |
| SMN1 | SNRNP70 | 0.809 | 0.77 | hein_WMM bioplex (SNRNP70) bioplex_WMM Guru youn_WMM hein (SMN1,SNRNP70) gupta_WMM fraction treiber_WMM |
| SMN1 | DDX20 | 0.797 | 0.764 | hein_WMM youn (DDX20) bioplex_WMM youn_WMM hein (SMN1) gupta_WMM treiber_WMM |
| SNRPC | SNRNP70 | 0.79 | 0.758 | hein_WMM bioplex (SNRNP70) bioplex_WMM youn_WMM hein (SNRNP70) gupta_WMM fraction treiber_WMM |
| GEMIN2 | DDX20 | 0.536 | 0.641 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN2) bioplex_WMM youn_WMM |
| GEMIN4 | GEMIN2 | 0.109 | 0.375 | hein_WMM bioplex (GEMIN2) bioplex_WMM youn_WMM |
| SMN1 | GEMIN2 | 0.046 | 0.292 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) treiber_WMM |
| GEMIN2 | SNRPC | 0.013 | 0.152 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GEMIN4 | SMN1 | 0.013 | 0.148 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) gupta_WMM |
| GEMIN4 | SNRPC | 0.012 | 0.151 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SNRPC | DDX20 | 0.01 | 0.105 | hein_WMM youn (DDX20) bioplex_WMM youn_WMM gupta_WMM |
| SMN1 | SNRPC | 0.009 | 0.11 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_00197 has an average edge precision of 0.512 which is ranked 2435 out of all 6965 complexes.
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