hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00198
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DPP8 | Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) | UniProt NCBI |
| LSM14A | Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) | UniProt NCBI |
| METAP2 | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | UniProt NCBI |
| METTL1 | tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) | UniProt NCBI |
| WDR4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008176 | 0.00450823411379 | 0.4 | METTL1 WDR4 | tRNA (guanine-N7-)-methyltransferase activity |
| REAC:R-HSA-6782315 | 0.0110102589414 | 0.4 | METTL1 WDR4 | tRNA modification in the nucleus and cytosol |
| MIRNA:hsa-miR-4474-3p | 0.0348186824875 | 0.4 | LSM14A METAP2 | hsa-miR-4474-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM14A | WDR4 | 0.134 | 0.405 | fraction |
| METTL1 | WDR4 | 0.09 | 0.354 | bioplex (METTL1,WDR4) bioplex_WMM fraction |
| DPP8 | WDR4 | 0.071 | 0.352 | bioplex () bioplex_WMM |
| LSM14A | METAP2 | 0.045 | 0.284 | bioplex_WMM fraction |
| LSM14A | METTL1 | 0.009 | 0.108 | fraction |
| METAP2 | WDR4 | 0.004 | 0.009 | fraction |
| METTL1 | METAP2 | 0.0 | 0.012 | fraction |
Images
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Complex HuMAP2_00198 has an average edge precision of 0.218 which is ranked 5896 out of all 6965 complexes.
Related Complexes