hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00204
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APEX1 | DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial] | UniProt NCBI |
| FCGR2A | Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32) | UniProt NCBI |
| FCGR2B | Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32) | UniProt NCBI |
| FCGR2C | Low affinity immunoglobulin gamma Fc region receptor II-c (IgG Fc receptor II-c) (CDw32) (Fc-gamma RII-c) (Fc-gamma-RIIc) (FcRII-c) (CD antigen CD32) | UniProt NCBI |
| MTTP | Microsomal triglyceride transfer protein large subunit | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0025300 | 0.00102214412276 | 0.5 | FCGR2A FCGR2B | Malar rash |
| HP:0003613 | 0.00206626211915 | 0.5 | FCGR2A FCGR2B | Antiphospholipid antibody positivity |
| HP:0002102 | 0.0038810174634 | 0.5 | FCGR2A FCGR2B | Pleuritis |
| KEGG:05150 | 0.00427326162018 | 0.5 | FCGR2A FCGR2B | Staphylococcus aureus infection |
| HP:0002725 | 0.00574003251223 | 0.5 | FCGR2A FCGR2B | Systemic lupus erythematosus |
| HP:0003493 | 0.00626129254237 | 0.5 | FCGR2A FCGR2B | Antinuclear antibody positivity |
| WP:WP2431 | 0.00652808434915 | 0.5 | FCGR2A APEX1 | Spinal Cord Injury |
| KEGG:04666 | 0.00761107721317 | 0.5 | FCGR2A FCGR2B | Fc gamma R-mediated phagocytosis |
| HP:0001701 | 0.00796059020261 | 0.5 | FCGR2A FCGR2B | Pericarditis |
| KEGG:04380 | 0.0104302851929 | 0.5 | FCGR2A FCGR2B | Osteoclast differentiation |
| HP:0045073 | 0.011244112798 | 0.5 | FCGR2A FCGR2B | Serositis |
| HP:0030057 | 0.0119684664945 | 0.5 | FCGR2A FCGR2B | Autoimmune antibody positivity |
| HP:0000123 | 0.0176695962482 | 0.5 | FCGR2A FCGR2B | Nephritis |
| KEGG:04145 | 0.0179080093657 | 0.5 | FCGR2A FCGR2B | Phagosome |
| KEGG:05152 | 0.0220952935316 | 0.5 | FCGR2A FCGR2B | Tuberculosis |
| HP:0001697 | 0.0300060012618 | 0.5 | FCGR2A FCGR2B | Abnormal pericardium morphology |
| HP:0002103 | 0.0470133620262 | 0.5 | FCGR2A FCGR2B | Abnormality of the pleura |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FCGR2A | FCGR2C | 0.959 | 0.863 | bioplex (FCGR2A) bioplex_WMM |
| FCGR2B | FCGR2A | 0.89 | 0.818 | bioplex (FCGR2B) bioplex_WMM |
| FCGR2A | MTTP | 0.118 | 0.391 | bioplex (FCGR2A) bioplex_WMM |
| FCGR2A | APEX1 | 0.025 | 0.212 | bioplex (FCGR2A) bioplex_WMM |
| FCGR2C | MTTP | 0.009 | 0.095 | bioplex_WMM WMM_only |
| APEX1 | FCGR2C | 0.008 | 0.081 | bioplex_WMM WMM_only |
| APEX1 | MTTP | 0.008 | 0.022 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00204 has an average edge precision of 0.355 which is ranked 3861 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| APEX1 | HuMAP2_00204 HuMAP2_01328 HuMAP2_01654 HuMAP2_04565 HuMAP2_05490 |
| FCGR2A | HuMAP2_00204 HuMAP2_01158 HuMAP2_02356 |
| FCGR2B | HuMAP2_00204 HuMAP2_01158 HuMAP2_02356 |
| FCGR2C | HuMAP2_00204 HuMAP2_01158 HuMAP2_02356 |
| MTTP | HuMAP2_00204 HuMAP2_02356 |