hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00207
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NXPE3 | NXPE family member 3 (Protein FAM55C) | UniProt NCBI |
| SEMA4D | Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) | UniProt NCBI |
| SCGB2A2 | Mammaglobin-A (Mammaglobin-1) (Secretoglobin family 2A member 2) | UniProt NCBI |
| ECEL1 | Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein) | UniProt NCBI |
| GNPAT | Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) | UniProt NCBI |
| NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)] | UniProt NCBI |
| CRLF1 | Cytokine receptor-like factor 1 (Cytokine-like factor 1) (CLF-1) (ZcytoR5) | UniProt NCBI |
| SEMA3C | Semaphorin-3C (Semaphorin-E) (Sema E) | UniProt NCBI |
| IDUA | Alpha-L-iduronidase (EC 3.2.1.76) | UniProt NCBI |
| VCAM1 | Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) | UniProt NCBI |
| CHST3 | Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0009811 | 0.00545058553897 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Abnormality of the elbow |
| HP:0002987 | 0.00665052648558 | 0.272727272727 | CRLF1 CHST3 ECEL1 | Elbow flexion contracture |
| HP:0001181 | 0.0098310528136 | 0.272727272727 | CRLF1 SEMA3C ECEL1 | Adducted thumb |
| HP:0012385 | 0.0107385878099 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Camptodactyly |
| HP:0100360 | 0.0115217837003 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Contractures of the joints of the upper limbs |
| REAC:R-HSA-1630316 | 0.0139567728461 | 0.272727272727 | IDUA NDST2 CHST3 | Glycosaminoglycan metabolism |
| HP:0030044 | 0.0141254621135 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Flexion contracture of digit |
| HP:0000470 | 0.0171398158768 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Short neck |
| HP:0000347 | 0.0174257119831 | 0.454545454545 | CRLF1 GNPAT ECEL1 CHST3 IDUA | Micrognathia |
| HP:0001371 | 0.0177397968202 | 0.454545454545 | CRLF1 GNPAT ECEL1 CHST3 IDUA | Flexion contracture |
| HP:0009118 | 0.0178984944428 | 0.454545454545 | CRLF1 GNPAT ECEL1 CHST3 IDUA | Aplasia/Hypoplasia of the mandible |
| HP:0009116 | 0.01937743509 | 0.454545454545 | CRLF1 GNPAT ECEL1 CHST3 IDUA | Aplasia/Hypoplasia involving bones of the skull |
| HP:0001172 | 0.0199937350282 | 0.363636363636 | CRLF1 CHST3 SEMA3C ECEL1 | Abnormal thumb morphology |
| HP:0100261 | 0.0202394628408 | 0.454545454545 | CRLF1 GNPAT ECEL1 CHST3 IDUA | Abnormal tendon morphology |
| HP:0003319 | 0.0263614136173 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Abnormality of the cervical spine |
| HP:0001376 | 0.0271090208045 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Limitation of joint mobility |
| HP:0002996 | 0.0284741447016 | 0.272727272727 | CRLF1 CHST3 ECEL1 | Limited elbow movement |
| HP:0003121 | 0.0302563836265 | 0.363636363636 | CRLF1 ECEL1 CHST3 IDUA | Limb joint contracture |
| HP:0009122 | 0.0333801038663 | 0.454545454545 | CRLF1 GNPAT ECEL1 CHST3 IDUA | Aplasia/hypoplasia affecting bones of the axial skeleton |
| HP:0002817 | 0.0474804692536 | 0.545454545455 | CRLF1 SEMA3C CHST3 IDUA ECEL1 GNPAT | Abnormality of the upper limb |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SCGB2A2 | SEMA3C | 0.073 | 0.354 | bioplex (SCGB2A2) bioplex_WMM |
| SCGB2A2 | SEMA4D | 0.071 | 0.353 | bioplex (SCGB2A2) bioplex_WMM |
| SCGB2A2 | ECEL1 | 0.041 | 0.269 | bioplex (SCGB2A2) bioplex_WMM |
| SCGB2A2 | IDUA | 0.036 | 0.264 | bioplex (SCGB2A2) bioplex_WMM |
| NXPE3 | SCGB2A2 | 0.036 | 0.265 | bioplex (SCGB2A2) bioplex_WMM |
| NDST2 | SCGB2A2 | 0.033 | 0.254 | bioplex (SCGB2A2) bioplex_WMM |
| SCGB2A2 | CRLF1 | 0.033 | 0.25 | bioplex (SCGB2A2) bioplex_WMM |
| VCAM1 | SEMA4D | 0.024 | 0.213 | bioplex (VCAM1) bioplex_WMM |
| CHST3 | SCGB2A2 | 0.022 | 0.207 | bioplex (SCGB2A2) bioplex_WMM |
| SCGB2A2 | GNPAT | 0.022 | 0.198 | bioplex (SCGB2A2) bioplex_WMM |
| NDST2 | SEMA4D | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CHST3 | NDST2 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CRLF1 | IDUA | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CRLF1 | SEMA3C | 0.008 | 0.091 | bioplex_WMM WMM_only |
| IDUA | SEMA3C | 0.008 | 0.091 | bioplex_WMM WMM_only |
| NXPE3 | ECEL1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| CHST3 | NXPE3 | 0.008 | 0.081 | bioplex_WMM WMM_only |
| CHST3 | IDUA | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CHST3 | CRLF1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CRLF1 | SEMA4D | 0.008 | 0.085 | bioplex_WMM WMM_only |
| IDUA | SEMA4D | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CHST3 | SEMA3C | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SEMA3C | SEMA4D | 0.008 | 0.06 | bioplex_WMM WMM_only |
| CRLF1 | ECEL1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| IDUA | ECEL1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| NXPE3 | IDUA | 0.008 | 0.046 | bioplex_WMM WMM_only |
| NXPE3 | CRLF1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| CHST3 | SEMA4D | 0.008 | 0.026 | bioplex_WMM WMM_only |
| NDST2 | IDUA | 0.008 | 0.024 | bioplex_WMM WMM_only |
| NDST2 | CRLF1 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| ECEL1 | SEMA3C | 0.008 | 0.025 | bioplex_WMM WMM_only |
| NXPE3 | SEMA3C | 0.008 | 0.029 | bioplex_WMM WMM_only |
| IDUA | GNPAT | 0.008 | 0.012 | bioplex_WMM WMM_only |
| CRLF1 | GNPAT | 0.008 | 0.012 | bioplex_WMM WMM_only |
| NDST2 | SEMA3C | 0.007 | 0.007 | bioplex_WMM WMM_only |
| CHST3 | ECEL1 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| ECEL1 | SEMA4D | 0.007 | 0.012 | bioplex_WMM WMM_only |
| NXPE3 | SEMA4D | 0.007 | 0.007 | bioplex_WMM WMM_only |
| NDST2 | ECEL1 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| GNPAT | SEMA3C | 0.007 | 0.006 | bioplex_WMM WMM_only |
| NXPE3 | NDST2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| GNPAT | SEMA4D | 0.007 | 0.007 | bioplex_WMM WMM_only |
| CHST3 | GNPAT | 0.007 | 0.007 | bioplex_WMM WMM_only |
| NXPE3 | GNPAT | 0.007 | 0.009 | bioplex_WMM WMM_only |
| ECEL1 | GNPAT | 0.007 | 0.0 | bioplex_WMM WMM_only |
| NDST2 | GNPAT | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00207 has an average edge precision of 0.09 which is ranked 6950 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NXPE3 | HuMAP2_00207 |
| SEMA4D | HuMAP2_00207 HuMAP2_03949 HuMAP2_05517 |
| SCGB2A2 | HuMAP2_00207 HuMAP2_05517 HuMAP2_06184 |
| ECEL1 | HuMAP2_00207 HuMAP2_05517 HuMAP2_06184 |
| GNPAT | HuMAP2_00207 HuMAP2_00393 HuMAP2_04640 HuMAP2_05102 |
| NDST2 | HuMAP2_00207 |
| CRLF1 | HuMAP2_00207 |
| SEMA3C | HuMAP2_00207 HuMAP2_05517 |
| IDUA | HuMAP2_00207 |
| VCAM1 | HuMAP2_00207 HuMAP2_03949 |
| CHST3 | HuMAP2_00005 HuMAP2_00207 HuMAP2_02362 HuMAP2_05758 |