hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00216
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUMO1 | Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1) | UniProt NCBI |
| KPNA4 | Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) | UniProt NCBI |
| RCC1 | Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) | UniProt NCBI |
| KPNA3 | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-913531 | 0.00115530951203 | 0.75 | KPNA4 SUMO1 KPNA3 | Interferon Signaling |
| REAC:R-HSA-168276 | 0.00667602194349 | 0.5 | KPNA4 KPNA3 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 0.0070462802506 | 0.5 | KPNA4 KPNA3 | Host Interactions with Influenza Factors |
| GO:0005635 | 0.0096936769593 | 1.0 | KPNA4 RCC1 SUMO1 KPNA3 | nuclear envelope |
| REAC:R-HSA-5663205 | 0.0100576606226 | 0.75 | KPNA4 RCC1 KPNA3 | Infectious disease |
| REAC:R-HSA-1169408 | 0.0221036214141 | 0.5 | KPNA4 KPNA3 | ISG15 antiviral mechanism |
| CORUM:7567 | 0.0249595281251 | 0.25 | SUMO1 | SUMO1-SYT7 complex |
| GO:0005643 | 0.0264744736345 | 0.75 | KPNA4 SUMO1 KPNA3 | nuclear pore |
| REAC:R-HSA-1169410 | 0.0269852439715 | 0.5 | KPNA4 KPNA3 | Antiviral mechanism by IFN-stimulated genes |
| MIRNA:hsa-miR-548c-3p | 0.0424083599964 | 0.75 | KPNA4 RCC1 KPNA3 | hsa-miR-548c-3p |
| CORUM:1056 | 0.0499140284799 | 0.25 | SUMO1 | ZNF198-SUMO1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KPNA4 | KPNA3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KPNA4 | RCC1 | 0.977 | 0.893 | hein_WMM bioplex (RCC1) bioplex_WMM youn_WMM hein (RCC1) gupta_WMM |
| RCC1 | KPNA3 | 0.928 | 0.844 | hein_WMM bioplex (RCC1) bioplex_WMM youn_WMM hein (RCC1) gupta_WMM |
| RCC1 | SUMO1 | 0.756 | 0.747 | hein_WMM bioplex (RCC1) bioplex_WMM youn_WMM hein (RCC1) gupta_WMM |
| KPNA3 | SUMO1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KPNA4 | SUMO1 | 0.011 | 0.145 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_00216 has an average edge precision of 0.621 which is ranked 1832 out of all 6965 complexes.
Related Complexes