hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00219

Confidence: Medium

Genename	Protein Name	Links
CRAMP1	Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein)	UniProt NCBI
GON4L	GON-4-like protein (GON-4 homolog)	UniProt NCBI
H2BC1	Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)	UniProt NCBI
H2AZ1	Histone H2A.Z (H2A/z)	UniProt NCBI
ARID5B	AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)	UniProt NCBI
H2BC13	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	UniProt NCBI
MIER1	Mesoderm induction early response protein 1 (Early response 1) (Er1) (Mi-er1) (hMi-er1)	UniProt NCBI
BAHD1	Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1)	UniProt NCBI
C16orf87	UPF0547 protein C16orf87	UniProt NCBI
MIER3	Mesoderm induction early response protein 3 (Mi-er3)	UniProt NCBI
HIST2H2AB	Histone H2A type 2-B	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:05322	4.48184774525e-05	0.363636363636	H2BC1 H2BC13 HIST2H2AB H2AZ1	Systemic lupus erythematosus
REAC:R-HSA-4839726	0.000171665950607	0.454545454545	H2BC1 ARID5B H2BC13 HIST2H2AB H2AZ1	Chromatin organization
REAC:R-HSA-3247509	0.000171665950607	0.454545454545	H2BC1 ARID5B H2BC13 HIST2H2AB H2AZ1	Chromatin modifying enzymes
KEGG:05034	0.000208143547432	0.363636363636	H2BC1 H2BC13 HIST2H2AB H2AZ1	Alcoholism
REAC:R-HSA-171306	0.00134246299119	0.272727272727	H2BC1 H2BC13 H2AZ1	Packaging Of Telomere Ends
REAC:R-HSA-73927	0.0015970307267	0.272727272727	H2BC1 H2BC13 H2AZ1	Depurination
REAC:R-HSA-110330	0.0015970307267	0.272727272727	H2BC1 H2BC13 H2AZ1	Recognition and association of DNA glycosylase with site containing an affected purine
REAC:R-HSA-110331	0.0015970307267	0.272727272727	H2BC1 H2BC13 H2AZ1	Cleavage of the damaged purine
REAC:R-HSA-73928	0.00198349035535	0.272727272727	H2BC1 H2BC13 H2AZ1	Depyrimidination
REAC:R-HSA-110328	0.00198349035535	0.272727272727	H2BC1 H2BC13 H2AZ1	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
REAC:R-HSA-110329	0.00198349035535	0.272727272727	H2BC1 H2BC13 H2AZ1	Cleavage of the damaged pyrimidine
REAC:R-HSA-73929	0.0020889055103	0.272727272727	H2BC1 H2BC13 H2AZ1	Base-Excision Repair, AP Site Formation
REAC:R-HSA-73728	0.00242722946189	0.272727272727	H2BC1 H2BC13 H2AZ1	RNA Polymerase I Promoter Opening
REAC:R-HSA-5334118	0.00267177367643	0.272727272727	H2BC1 H2BC13 H2AZ1	DNA methylation
REAC:R-HSA-5625886	0.002932068383	0.272727272727	H2BC1 H2BC13 H2AZ1	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
REAC:R-HSA-427359	0.00306827021441	0.272727272727	H2BC1 H2BC13 H2AZ1	SIRT1 negatively regulates rRNA expression
REAC:R-HSA-2299718	0.00381218288361	0.272727272727	H2BC1 H2BC13 H2AZ1	Condensation of Prophase Chromosomes
REAC:R-HSA-606279	0.00381218288361	0.272727272727	H2BC1 H2BC13 H2AZ1	Deposition of new CENPA-containing nucleosomes at the centromere
REAC:R-HSA-212300	0.00381218288361	0.272727272727	H2BC1 H2BC13 H2AZ1	PRC2 methylates histones and DNA
REAC:R-HSA-774815	0.00381218288361	0.272727272727	H2BC1 H2BC13 H2AZ1	Nucleosome assembly
HPA:006010_02	0.00387382576145	0.545454545455	H2BC13 CRAMP1 C16orf87 ARID5B H2AZ1 HIST2H2AB	caudate; glial cells[Uncertain,Medium]
REAC:R-HSA-427389	0.00431096631005	0.272727272727	H2BC1 H2BC13 H2AZ1	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
REAC:R-HSA-1221632	0.00431096631005	0.272727272727	H2BC1 H2BC13 H2AZ1	Meiotic synapsis
REAC:R-HSA-2559586	0.00504045487762	0.272727272727	H2BC1 H2BC13 H2AZ1	DNA Damage/Telomere Stress Induced Senescence
REAC:R-HSA-157579	0.00543386249874	0.272727272727	H2BC1 H2BC13 H2AZ1	Telomere Maintenance
REAC:R-HSA-9616222	0.00584699507217	0.272727272727	H2BC1 H2BC13 H2AZ1	Transcriptional regulation of granulopoiesis
REAC:R-HSA-912446	0.00628031267746	0.272727272727	H2BC1 H2BC13 H2AZ1	Meiotic recombination
REAC:R-HSA-73884	0.00673427382496	0.272727272727	H2BC1 H2BC13 H2AZ1	Base Excision Repair
REAC:R-HSA-5250924	0.00720933545885	0.272727272727	H2BC1 H2BC13 H2AZ1	B-WICH complex positively regulates rRNA expression
REAC:R-HSA-201722	0.00720933545885	0.272727272727	H2BC1 H2BC13 H2AZ1	Formation of the beta-catenin:TCF transactivating complex
REAC:R-HSA-73772	0.00745492132573	0.272727272727	H2BC1 H2BC13 H2AZ1	RNA Polymerase I Promoter Escape
REAC:R-HSA-1912408	0.00770595296013	0.272727272727	H2BC1 H2BC13 H2AZ1	Pre-NOTCH Transcription and Translation
REAC:R-HSA-8936459	0.00796248704092	0.272727272727	H2BC1 H2BC13 H2AZ1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
REAC:R-HSA-5625740	0.00822458014965	0.272727272727	H2BC1 H2BC13 H2AZ1	RHO GTPases activate PKNs
REAC:R-HSA-3214815	0.00822458014965	0.272727272727	H2BC1 HIST2H2AB H2BC13	HDACs deacetylate histones
MIRNA:hsa-miR-6822-3p	0.0101612593228	0.272727272727	H2BC1 HIST2H2AB H2BC13	hsa-miR-6822-3p
REAC:R-HSA-977225	0.0105282077696	0.272727272727	H2BC1 H2BC13 H2AZ1	Amyloid fiber formation
REAC:R-HSA-5578749	0.0108428622879	0.272727272727	H2BC1 H2BC13 H2AZ1	Transcriptional regulation by small RNAs
REAC:R-HSA-5250913	0.0114905853756	0.272727272727	H2BC1 H2BC13 H2AZ1	Positive epigenetic regulation of rRNA expression
REAC:R-HSA-427413	0.0118237648833	0.272727272727	H2BC1 H2BC13 H2AZ1	NoRC negatively regulates rRNA expression
REAC:R-HSA-2559582	0.0121632301653	0.272727272727	H2BC1 H2BC13 H2AZ1	Senescence-Associated Secretory Phenotype (SASP)
REAC:R-HSA-1912422	0.0125090364506	0.272727272727	H2BC1 H2BC13 H2AZ1	Pre-NOTCH Expression and Processing
REAC:R-HSA-5250941	0.0128612388721	0.272727272727	H2BC1 H2BC13 H2AZ1	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-73886	0.0128612388721	0.272727272727	H2BC1 H2BC13 H2AZ1	Chromosome Maintenance
REAC:R-HSA-73854	0.0132198924669	0.272727272727	H2BC1 H2BC13 H2AZ1	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	0.0135850521763	0.272727272727	H2BC1 H2BC13 H2AZ1	RNA Polymerase I Transcription
REAC:R-HSA-1500620	0.0151118476424	0.272727272727	H2BC1 H2BC13 H2AZ1	Meiosis
REAC:R-HSA-5617472	0.0155103587014	0.272727272727	H2BC1 H2BC13 H2AZ1	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	0.0155103587014	0.272727272727	H2BC1 H2BC13 H2AZ1	Activation of HOX genes during differentiation
REAC:R-HSA-2559580	0.0184943140157	0.272727272727	H2BC1 H2BC13 H2AZ1	Oxidative Stress Induced Senescence
REAC:R-HSA-8939236	0.0203569016388	0.272727272727	H2BC1 H2BC13 H2AZ1	RUNX1 regulates transcription of genes involved in differentiation of HSCs
REAC:R-HSA-1474165	0.0208409790065	0.272727272727	H2BC1 H2BC13 H2AZ1	Reproduction
REAC:R-HSA-68875	0.0233746091412	0.272727272727	H2BC1 H2BC13 H2AZ1	Mitotic Prophase
REAC:R-HSA-211000	0.0233746091412	0.272727272727	H2BC1 H2BC13 H2AZ1	Gene Silencing by RNA
HPA:007020_03	0.0268340564785	0.363636363636	H2AZ1 HIST2H2AB GON4L H2BC13	cerebellum; cells in granular layer[Uncertain,High]
REAC:R-HSA-9018519	0.0284273862636	0.272727272727	H2BC1 H2BC13 H2AZ1	Estrogen-dependent gene expression
REAC:R-HSA-3214847	0.0290291826306	0.272727272727	H2BC1 HIST2H2AB H2BC13	HATs acetylate histones
REAC:R-HSA-212165	0.0315195457962	0.272727272727	H2BC1 H2BC13 H2AZ1	Epigenetic regulation of gene expression

Edges

Protein 1	Protein 2	Score	Precision	Evidence
MIER1	H2BC1	0.999	0.949	bioplex (H2BC1) bioplex_WMM
H2BC1	BAHD1	0.998	0.942	bioplex (H2BC1) bioplex_WMM
H2BC1	MIER3	0.988	0.901	bioplex (H2BC1) bioplex_WMM
H2BC1	H2BC13	0.94	0.852	bioplex (H2BC1) bioplex_WMM
H2BC1	C16orf87	0.823	0.774	bioplex (H2BC1) bioplex_WMM
GON4L	H2BC1	0.82	0.773	bioplex (H2BC1) bioplex_WMM
C16orf87	MIER3	0.777	0.752	bioplex (C16orf87) bioplex_WMM
GON4L	CRAMP1	0.581	0.663	bioplex (CRAMP1) bioplex_WMM
C16orf87	ARID5B	0.192	0.445	bioplex (C16orf87) bioplex_WMM
MIER1	C16orf87	0.186	0.441	bioplex (C16orf87) bioplex_WMM
H2BC1	ARID5B	0.072	0.353	bioplex (H2BC1) bioplex_WMM
H2BC1	H2AZ1	0.071	0.351	bioplex (H2BC1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
H2BC1	CRAMP1	0.065	0.348	bioplex (H2BC1) bioplex_WMM youn_WMM
H2BC1	HIST2H2AB	0.04	0.268	bioplex (H2BC1) bioplex_WMM
MIER1	MIER3	0.014	0.138	hein_WMM bioplex_WMM WMM_only
ARID5B	MIER3	0.012	0.147	bioplex_WMM WMM_only
ARID5B	BAHD1	0.011	0.145	bioplex_WMM WMM_only
BAHD1	MIER3	0.011	0.145	bioplex_WMM WMM_only
C16orf87	BAHD1	0.011	0.145	bioplex_WMM WMM_only
MIER1	ARID5B	0.01	0.139	hein_WMM bioplex_WMM youn_WMM WMM_only
GON4L	C16orf87	0.01	0.126	bioplex_WMM WMM_only
GON4L	MIER3	0.01	0.126	bioplex_WMM WMM_only
MIER1	BAHD1	0.01	0.121	bioplex_WMM WMM_only
CRAMP1	C16orf87	0.01	0.098	bioplex_WMM WMM_only
CRAMP1	MIER3	0.01	0.098	bioplex_WMM WMM_only
GON4L	MIER1	0.009	0.104	bioplex_WMM WMM_only
C16orf87	H2AZ1	0.009	0.108	bioplex (C16orf87) bioplex_WMM
MIER1	CRAMP1	0.009	0.103	bioplex_WMM youn_WMM WMM_only
GON4L	BAHD1	0.009	0.094	bioplex_WMM WMM_only
CRAMP1	BAHD1	0.009	0.098	bioplex_WMM WMM_only
GON4L	ARID5B	0.008	0.088	bioplex_WMM WMM_only
CRAMP1	ARID5B	0.008	0.089	bioplex_WMM youn_WMM WMM_only
BAHD1	H2BC13	0.008	0.084	bioplex_WMM WMM_only
C16orf87	H2BC13	0.008	0.06	bioplex_WMM WMM_only
H2BC13	MIER3	0.008	0.06	bioplex_WMM WMM_only
ARID5B	H2BC13	0.008	0.06	bioplex_WMM WMM_only
GON4L	H2BC13	0.008	0.06	bioplex_WMM WMM_only
CRAMP1	H2BC13	0.008	0.052	bioplex_WMM WMM_only
H2AZ1	BAHD1	0.008	0.025	bioplex_WMM WMM_only
MIER1	H2BC13	0.008	0.014	bioplex_WMM WMM_only
H2AZ1	ARID5B	0.007	0.009	bioplex_WMM youn_WMM WMM_only
H2AZ1	MIER3	0.007	0.006	bioplex_WMM WMM_only
BAHD1	HIST2H2AB	0.007	0.004	bioplex_WMM gupta_WMM WMM_only
GON4L	HIST2H2AB	0.007	0.006	bioplex_WMM WMM_only
MIER3	HIST2H2AB	0.007	0.003	bioplex_WMM WMM_only
C16orf87	HIST2H2AB	0.007	0.003	bioplex_WMM WMM_only
CRAMP1	HIST2H2AB	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
GON4L	H2AZ1	0.007	0.002	bioplex_WMM WMM_only
ARID5B	HIST2H2AB	0.007	0.003	bioplex_WMM youn_WMM WMM_only
CRAMP1	H2AZ1	0.007	0.0	bioplex_WMM youn_WMM WMM_only
MIER1	H2AZ1	0.007	0.005	bioplex_WMM youn_WMM WMM_only
H2AZ1	H2BC13	0.007	0.007	bioplex_WMM WMM_only
MIER1	HIST2H2AB	0.007	0.004	bioplex_WMM youn_WMM WMM_only
H2BC13	HIST2H2AB	0.007	0.005	bioplex_WMM WMM_only
H2AZ1	HIST2H2AB	0.0	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only

Images

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Complex HuMAP2_00219 has an average edge precision of 0.207 which is ranked 6073 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CRAMP1	HuMAP2_00219 HuMAP2_03095 HuMAP2_06275 HuMAP2_06636
GON4L	HuMAP2_00219 HuMAP2_03095 HuMAP2_06636
H2BC1	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_06067 HuMAP2_06636 HuMAP2_06674
H2AZ1	HuMAP2_00219 HuMAP2_02888 HuMAP2_06067 HuMAP2_06636
ARID5B	HuMAP2_00219 HuMAP2_01431 HuMAP2_06799
H2BC13	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_05645 HuMAP2_06067 HuMAP2_06674
MIER1	HuMAP2_00219 HuMAP2_01431 HuMAP2_01712 HuMAP2_02553 HuMAP2_03590 HuMAP2_05240 HuMAP2_06636 HuMAP2_06674
BAHD1	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_06636 HuMAP2_06674
C16orf87	HuMAP2_00219 HuMAP2_01431 HuMAP2_03601 HuMAP2_06674 HuMAP2_06799
MIER3	HuMAP2_00219 HuMAP2_01431 HuMAP2_06674 HuMAP2_06799
HIST2H2AB	HuMAP2_00219 HuMAP2_00547 HuMAP2_03607 HuMAP2_03709 HuMAP2_06596

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00219