hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00220
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CPSF4 | Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) | UniProt NCBI |
| FIP1L1 | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | UniProt NCBI |
| CPSF2 | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | UniProt NCBI |
| KLK6 | Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme) | UniProt NCBI |
| WDR33 | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | UniProt NCBI |
| CPSF1 | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | UniProt NCBI |
| CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1144 | 1.83011155706e-16 | 0.714285714286 | CPSF1 CPSF3 CPSF4 CPSF2 FIP1L1 | Cleavage and polyadenylation factor (CPSF) |
| REAC:R-HSA-77595 | 2.09534401311e-15 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Processing of Intronless Pre-mRNAs |
| REAC:R-HSA-75067 | 2.90797053641e-14 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Processing of Capped Intronless Pre-mRNA |
| REAC:R-HSA-159231 | 1.79351701411e-13 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Transport of Mature mRNA Derived from an Intronless Transcript |
| GO:0005847 | 1.84945530423e-13 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA cleavage and polyadenylation specificity factor complex |
| REAC:R-HSA-159234 | 2.12967861653e-13 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| GO:0005849 | 6.26507859919e-13 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA cleavage factor complex |
| REAC:R-HSA-72187 | 1.99055233916e-12 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 5.23397909171e-12 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA Polymerase II Transcription Termination |
| KEGG:03015 | 1.30650341221e-11 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA surveillance pathway |
| REAC:R-HSA-72202 | 1.82490376468e-11 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Transport of Mature Transcript to Cytoplasm |
| GO:0006369 | 3.74460063447e-11 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | termination of RNA polymerase II transcription |
| REAC:R-HSA-72163 | 3.1044415985e-09 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA Splicing - Major Pathway |
| GO:0006353 | 3.91857948075e-09 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | DNA-templated transcription, termination |
| REAC:R-HSA-72172 | 4.05457772457e-09 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA Splicing |
| REAC:R-HSA-72203 | 1.67289912286e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0031124 | 1.75260469403e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA 3'-end processing |
| GO:0071427 | 4.15197125222e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0006406 | 4.15197125222e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA export from nucleus |
| GO:0051028 | 5.49473321162e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA transport |
| GO:0071426 | 9.2783024887e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 9.75354752616e-08 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | ribonucleoprotein complex localization |
| CORUM:1147 | 1.18258642143e-07 | 0.428571428571 | CPSF1 CPSF2 CPSF3 | Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) |
| GO:0006405 | 1.43380219169e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA export from nucleus |
| GO:0031123 | 1.64649271638e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA 3'-end processing |
| GO:0050657 | 3.2764180303e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | nucleic acid transport |
| GO:0050658 | 3.2764180303e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA transport |
| GO:0051236 | 3.69655724667e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | establishment of RNA localization |
| GO:0006611 | 4.49619679719e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | protein export from nucleus |
| GO:0051168 | 7.01892721448e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | nuclear export |
| GO:0015931 | 7.80651437419e-07 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | nucleobase-containing compound transport |
| GO:0006403 | 1.21231873965e-06 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA localization |
| GO:0006379 | 2.60687308082e-06 | 0.571428571429 | CPSF1 CPSF3 CPSF4 FIP1L1 | mRNA cleavage |
| GO:0031503 | 4.27721086393e-06 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | protein-containing complex localization |
| REAC:R-HSA-8953854 | 7.75839378739e-06 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Metabolism of RNA |
| WP:WP411 | 8.63257872854e-06 | 0.571428571429 | CPSF1 CPSF4 CPSF2 CPSF3 | mRNA Processing |
| GO:0006913 | 1.10705652415e-05 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | nucleocytoplasmic transport |
| GO:0051169 | 1.18405919677e-05 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | nuclear transport |
| GO:0000377 | 2.77103722432e-05 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 2.77103722432e-05 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA splicing, via spliceosome |
| GO:0000375 | 2.93564114097e-05 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA splicing, via transesterification reactions |
| GO:0008380 | 7.74025572009e-05 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA splicing |
| GO:0006378 | 7.75809589829e-05 | 0.571428571429 | CPSF1 CPSF3 WDR33 FIP1L1 | mRNA polyadenylation |
| GO:0043631 | 9.49866794351e-05 | 0.571428571429 | CPSF1 CPSF3 WDR33 FIP1L1 | RNA polyadenylation |
| GO:0006397 | 0.000120054472817 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA processing |
| GO:0090501 | 0.00016496565098 | 0.571428571429 | CPSF1 CPSF3 CPSF4 FIP1L1 | RNA phosphodiester bond hydrolysis |
| REAC:R-HSA-73857 | 0.00023249479605 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.000444522787502 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | Gene expression (Transcription) |
| GO:0098789 | 0.000698035893352 | 0.428571428571 | CPSF1 CPSF4 FIP1L1 | pre-mRNA cleavage required for polyadenylation |
| GO:0098787 | 0.000907263777246 | 0.428571428571 | CPSF1 CPSF4 FIP1L1 | mRNA cleavage involved in mRNA processing |
| GO:0016071 | 0.00396065506267 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | mRNA metabolic process |
| GO:0006396 | 0.00636934613966 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | RNA processing |
| GO:0090305 | 0.00892801112716 | 0.571428571429 | CPSF1 CPSF3 CPSF4 FIP1L1 | nucleic acid phosphodiester bond hydrolysis |
| GO:0006886 | 0.0180209467821 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | intracellular protein transport |
| GO:0044451 | 0.0180209467821 | 0.857142857143 | CPSF1 WDR33 CPSF3 FIP1L1 CPSF2 CPSF4 | nucleoplasm part |
| REAC:R-HSA-6784531 | 0.0447853370322 | 0.285714285714 | CPSF1 CPSF4 | tRNA processing in the nucleus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CPSF1 | FIP1L1 | 1.0 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM youn_WMM hein (FIP1L1) Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF1 | 1.0 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| CPSF3 | CPSF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| FIP1L1 | CPSF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (FIP1L1) Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF4 | 1.0 | 0.949 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CPSF1 | CPSF3 | 0.999 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM Guru youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| FIP1L1 | CPSF4 | 0.999 | 0.949 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM hein (FIP1L1) gupta_WMM treiber_WMM |
| CPSF1 | CPSF2 | 0.999 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF3 | 0.999 | 0.947 | hein_WMM bioplex_WMM Guru youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| CPSF4 | CPSF2 | 0.995 | 0.924 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CPSF1 | CPSF4 | 0.988 | 0.901 | hein_WMM youn (CPSF1) bioplex (CPSF4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| WDR33 | CPSF2 | 0.974 | 0.886 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR33 | FIP1L1 | 0.969 | 0.88 | hein_WMM bioplex_WMM youn_WMM hein (FIP1L1) gupta_WMM treiber_WMM |
| CPSF3 | CPSF4 | 0.469 | 0.605 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM hein (CPSF3) gupta_WMM |
| FIP1L1 | CPSF3 | 0.141 | 0.405 | hein_WMM bioplex_WMM youn_WMM hein (CPSF3,FIP1L1) gupta_WMM treiber_WMM |
| CPSF4 | KLK6 | 0.041 | 0.269 | bioplex (CPSF4) bioplex_WMM |
| WDR33 | KLK6 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| CPSF1 | KLK6 | 0.007 | 0.01 | bioplex (KLK6) bioplex_WMM |
| CPSF3 | KLK6 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| FIP1L1 | KLK6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CPSF2 | KLK6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00220 has an average edge precision of 0.64 which is ranked 1721 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CPSF4 | HuMAP2_00220 HuMAP2_00374 HuMAP2_03166 HuMAP2_04008 HuMAP2_06540 |
| FIP1L1 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |
| CPSF2 | HuMAP2_00220 HuMAP2_00374 HuMAP2_02763 HuMAP2_06540 |
| KLK6 | HuMAP2_00220 HuMAP2_00374 HuMAP2_03166 HuMAP2_04008 |
| WDR33 | HuMAP2_00220 HuMAP2_00374 HuMAP2_05059 HuMAP2_06540 |
| CPSF1 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |
| CPSF3 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |