hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00221
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYOF | Myoferlin (Fer-1-like protein 3) | UniProt NCBI |
| NDUFV1 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-51kD) (CI-51kD) (NADH dehydrogenase flavoprotein 1) (NADH-ubiquinone oxidoreductase 51 kDa subunit) | UniProt NCBI |
| NDUFA10 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) | UniProt NCBI |
| NDUFB4 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 (Complex I-B15) (CI-B15) (NADH-ubiquinone oxidoreductase B15 subunit) | UniProt NCBI |
| UQCRFS1 | Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 7.1.1.8) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (Ubiquinol-cytochrome c reductase 8 kDa protein)] | UniProt NCBI |
| ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | UniProt NCBI |
| ACAD10 | Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP111 | 2.61426954215e-06 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Electron Transport Chain (OXPHOS system in mitochondria) |
| KEGG:00190 | 6.74279515347e-06 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Oxidative phosphorylation |
| REAC:R-HSA-611105 | 8.58266296478e-06 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Respiratory electron transport |
| KEGG:05012 | 8.78335256238e-06 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Parkinson disease |
| KEGG:04932 | 1.09194334287e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP4396 | 1.24852319142e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Nonalcoholic fatty liver disease |
| KEGG:05010 | 1.96839529328e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Alzheimer disease |
| REAC:R-HSA-163200 | 2.00804467107e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| CORUM:178 | 3.31613226595e-05 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:05016 | 3.36258525756e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Huntington disease |
| KEGG:04714 | 6.68717448228e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | Thermogenesis |
| WP:WP4324 | 7.84212066265e-05 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-1428517 | 8.28344976794e-05 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP623 | 8.77891989719e-05 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | Oxidative phosphorylation |
| REAC:R-HSA-6799198 | 0.0002326333618 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | Complex I biogenesis |
| CORUM:2948 | 0.000552822266572 | 0.285714285714 | NDUFV1 NDUFA10 | Respiratory chain complex I (incomplete intermediate), mitochondrial |
| GO:0098803 | 0.000688210464691 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | respiratory chain complex |
| GO:0005746 | 0.000730443752297 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | mitochondrial respirasome |
| GO:0070469 | 0.000919053594983 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | respirasome |
| GO:0042775 | 0.00120347761901 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | mitochondrial ATP synthesis coupled electron transport |
| KEGG:04723 | 0.00121622680213 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | Retrograde endocannabinoid signaling |
| GO:0042773 | 0.00126745802052 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | ATP synthesis coupled electron transport |
| GO:1990204 | 0.00196423913453 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | oxidoreductase complex |
| GO:0022904 | 0.00225019801643 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | respiratory electron transport chain |
| GO:0022900 | 0.00235209893628 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | electron transport chain |
| GO:0098800 | 0.00559719590834 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | inner mitochondrial membrane protein complex |
| GO:0006119 | 0.00665529116898 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | oxidative phosphorylation |
| GO:0045333 | 0.0143396670291 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | cellular respiration |
| GO:0055114 | 0.0254241642855 | 0.714285714286 | NDUFV1 UQCRFS1 NDUFA10 ACAD10 NDUFB4 | oxidation-reduction process |
| GO:0050136 | 0.026626530587 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | NADH dehydrogenase (quinone) activity |
| GO:0008137 | 0.026626530587 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | NADH dehydrogenase (ubiquinone) activity |
| GO:0003954 | 0.026626530587 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | NADH dehydrogenase activity |
| KEGG:04260 | 0.0278177533068 | 0.285714285714 | UQCRFS1 ATP1A1 | Cardiac muscle contraction |
| GO:0044455 | 0.0343259651745 | 0.571428571429 | NDUFV1 UQCRFS1 NDUFA10 NDUFB4 | mitochondrial membrane part |
| GO:0045271 | 0.0417514312642 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | respiratory chain complex I |
| GO:0030964 | 0.0417514312642 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | NADH dehydrogenase complex |
| GO:0005747 | 0.0417514312642 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | mitochondrial respiratory chain complex I |
| GO:0006120 | 0.0447246492298 | 0.428571428571 | NDUFV1 NDUFA10 NDUFB4 | mitochondrial electron transport, NADH to ubiquinone |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFA10 | NDUFV1 | 0.835 | 0.78 | hein_WMM bioplex (NDUFA10) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFV1 | ATP1A1 | 0.113 | 0.381 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFB4 | NDUFV1 | 0.104 | 0.366 | hein_WMM bioplex_WMM gupta_WMM fraction |
| MYOF | ATP1A1 | 0.082 | 0.351 | hein_WMM fraction treiber_WMM |
| NDUFA10 | ATP1A1 | 0.067 | 0.35 | hein_WMM bioplex (NDUFA10) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| NDUFA10 | NDUFB4 | 0.065 | 0.347 | hein_WMM bioplex_WMM gupta_WMM fraction |
| UQCRFS1 | NDUFV1 | 0.058 | 0.325 | hein_WMM bioplex_WMM fraction |
| NDUFA10 | ACAD10 | 0.042 | 0.27 | bioplex (NDUFA10) bioplex_WMM |
| NDUFB4 | ATP1A1 | 0.041 | 0.269 | hein_WMM bioplex_WMM gupta_WMM fraction |
| NDUFB4 | UQCRFS1 | 0.029 | 0.232 | hein_WMM bioplex_WMM fraction |
| NDUFV1 | MYOF | 0.007 | 0.002 | hein_WMM WMM_only |
| UQCRFS1 | ACAD10 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| UQCRFS1 | MYOF | 0.007 | 0.003 | hein_WMM WMM_only |
| ATP1A1 | ACAD10 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| NDUFA10 | MYOF | 0.007 | 0.005 | hein_WMM WMM_only |
| NDUFV1 | ACAD10 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| NDUFB4 | MYOF | 0.006 | 0.004 | hein_WMM WMM_only |
| NDUFA10 | UQCRFS1 | 0.006 | 0.007 | hein_WMM bioplex (NDUFA10) bioplex_WMM youn_WMM fraction |
| NDUFB4 | ACAD10 | 0.006 | 0.007 | bioplex_WMM WMM_only |
| UQCRFS1 | ATP1A1 | 0.0 | 0.001 | hein_WMM bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_00221 has an average edge precision of 0.185 which is ranked 6371 out of all 6965 complexes.
Related Complexes