hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00225
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLH | DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) | UniProt NCBI |
| LSM2 | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | UniProt NCBI |
| AKAP7 | A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) | UniProt NCBI |
| LSM1 | U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) | UniProt NCBI |
| LSM3 | U6 snRNA-associated Sm-like protein LSm3 | UniProt NCBI |
| PATL1 | Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b) | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | UniProt NCBI |
| LSM5 | U6 snRNA-associated Sm-like protein LSm5 | UniProt NCBI |
| LSM7 | U6 snRNA-associated Sm-like protein LSm7 | UniProt NCBI |
| LSM8 | U6 snRNA-associated Sm-like protein LSm8 | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:562 | 6.93111371734e-22 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | LSm2-8 complex |
| CORUM:561 | 6.93111371734e-22 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | LSm1-7 complex |
| REAC:R-HSA-430039 | 3.87944171751e-21 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | mRNA decay by 5' to 3' exoribonuclease |
| GO:0120115 | 5.12209303711e-19 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | Lsm2-8 complex |
| KEGG:03018 | 3.53108304864e-18 | 0.818181818182 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | RNA degradation |
| GO:0005688 | 4.09671104818e-18 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | U6 snRNP |
| REAC:R-HSA-429914 | 8.50090241382e-16 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | Deadenylation-dependent mRNA decay |
| GO:0043928 | 1.90227471901e-15 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | exonucleolytic catabolism of deadenylated mRNA |
| GO:0000291 | 3.22349678808e-15 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| GO:0097526 | 1.03712820242e-12 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | spliceosomal tri-snRNP complex |
| GO:0046540 | 1.03712820242e-12 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | U4/U6 x U5 tri-snRNP complex |
| GO:0000288 | 1.28486008019e-12 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0120114 | 2.04979800456e-12 | 0.727272727273 | LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | Sm-like protein family complex |
| GO:1990726 | 3.78467070001e-12 | 0.454545454545 | LSM1 LSM3 LSM7 LSM2 LSM5 | Lsm1-7-Pat1 complex |
| KEGG:03040 | 4.73521310588e-11 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | Spliceosome |
| GO:0071005 | 5.06464425371e-11 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | U2-type precatalytic spliceosome |
| GO:0071011 | 5.86899962959e-11 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | precatalytic spliceosome |
| GO:0097525 | 1.33835955522e-10 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | spliceosomal snRNP complex |
| GO:0030532 | 2.79677650552e-10 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | small nuclear ribonucleoprotein complex |
| REAC:R-HSA-72163 | 2.15082135089e-09 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 2.93553742923e-09 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | mRNA Splicing |
| GO:0005684 | 4.06454894519e-09 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | U2-type spliceosomal complex |
| REAC:R-HSA-8953854 | 6.23810581973e-09 | 0.818181818182 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | Metabolism of RNA |
| GO:0000956 | 6.48033510439e-09 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-72203 | 1.52740181748e-08 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000932 | 1.23851013548e-07 | 0.545454545455 | LSM3 PATL1 LSM6 LSM2 LSM1 LSM4 | P-body |
| GO:0005681 | 2.40757198804e-07 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | spliceosomal complex |
| GO:0000375 | 2.86186002087e-07 | 0.727272727273 | LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | RNA splicing, via transesterification reactions |
| GO:0006402 | 4.9206074677e-07 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | mRNA catabolic process |
| GO:0006401 | 9.74806735883e-07 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | RNA catabolic process |
| GO:0008380 | 1.04048960204e-06 | 0.727272727273 | LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | RNA splicing |
| GO:0006397 | 1.86553771789e-06 | 0.727272727273 | LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | mRNA processing |
| CORUM:351 | 2.04045989917e-06 | 0.454545454545 | LSM2 LSM3 LSM4 LSM6 LSM7 | Spliceosome |
| GO:0017070 | 2.64968960261e-06 | 0.363636363636 | LSM2 LSM4 LSM7 LSM8 | U6 snRNA binding |
| GO:0016071 | 3.17172517553e-06 | 0.818181818182 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | mRNA metabolic process |
| GO:1990904 | 5.17157216345e-06 | 0.818181818182 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | ribonucleoprotein complex |
| GO:0034655 | 5.82753116476e-06 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | nucleobase-containing compound catabolic process |
| GO:0046700 | 1.04687845416e-05 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | heterocycle catabolic process |
| GO:0044270 | 1.06387947282e-05 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | cellular nitrogen compound catabolic process |
| GO:0019439 | 1.28748036935e-05 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | aromatic compound catabolic process |
| GO:1901361 | 1.7517714484e-05 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | organic cyclic compound catabolic process |
| GO:0000377 | 2.54243097558e-05 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 2.54243097558e-05 | 0.636363636364 | LSM5 LSM7 LSM3 LSM6 LSM2 LSM8 LSM4 | mRNA splicing, via spliceosome |
| GO:0036464 | 6.95814165825e-05 | 0.545454545455 | LSM3 PATL1 LSM6 LSM2 LSM1 LSM4 | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 9.58847192282e-05 | 0.545454545455 | LSM3 PATL1 LSM6 LSM2 LSM1 LSM4 | ribonucleoprotein granule |
| GO:0006396 | 0.000361003779895 | 0.727272727273 | LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | RNA processing |
| GO:0017069 | 0.000525134045179 | 0.363636363636 | LSM2 LSM4 LSM7 LSM8 | snRNA binding |
| GO:0003723 | 0.0015476443203 | 0.818181818182 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM8 LSM1 LSM2 LSM4 | RNA binding |
| GO:0044265 | 0.00214155900479 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | cellular macromolecule catabolic process |
| CORUM:5613 | 0.00400364699879 | 0.181818181818 | LSM2 LSM8 | Emerin complex 25 |
| CORUM:0000000 | 0.00414038065946 | 0.818181818182 | LSM5 LSM8 LSM7 LSM3 POLH LSM6 LSM2 LSM1 LSM4 | CORUM root |
| GO:0009057 | 0.00749385284278 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | macromolecule catabolic process |
| GO:0033962 | 0.0083477795687 | 0.272727272727 | LSM3 LSM4 PATL1 | cytoplasmic mRNA processing body assembly |
| GO:0003676 | 0.00902997612677 | 0.909090909091 | PATL1 LSM5 LSM8 LSM7 LSM3 POLH LSM6 LSM2 LSM1 LSM4 | nucleic acid binding |
| GO:0010629 | 0.0411186050798 | 0.727272727273 | PATL1 LSM5 LSM7 LSM3 LSM6 LSM2 LSM1 LSM4 | negative regulation of gene expression |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM6 | LSM3 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM8 | LSM3 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM6 | 1.0 | 0.949 | youn (LSM2) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM8 | LSM2 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM8 | LSM6 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM3 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| LSM8 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM4 | 1.0 | 0.949 | youn (LSM2,LSM4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| LSM6 | LSM7 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM3 | LSM7 | 0.999 | 0.949 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM5 | PATL1 | 0.975 | 0.887 | bioplex (LSM5) bioplex_WMM youn_WMM |
| LSM4 | LSM3 | 0.959 | 0.863 | youn (LSM4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM |
| LSM2 | LSM7 | 0.952 | 0.858 | youn (LSM2) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM8 | LSM7 | 0.945 | 0.856 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | LSM1 | 0.634 | 0.684 | youn (LSM1) bioplex (LSM6) bioplex_WMM youn_WMM |
| LSM6 | PATL1 | 0.577 | 0.659 | youn (PATL1) bioplex (LSM6,PATL1) bioplex_WMM youn_WMM |
| LSM5 | LSM4 | 0.52 | 0.633 | youn (LSM4) bioplex (LSM5) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| LSM5 | LSM2 | 0.492 | 0.619 | youn (LSM2) bioplex (LSM5) bioplex_WMM Guru youn_WMM fraction |
| LSM5 | LSM8 | 0.484 | 0.614 | bioplex (LSM5) bioplex_WMM Guru youn_WMM fraction |
| LSM5 | LSM6 | 0.451 | 0.595 | bioplex (LSM5,LSM6) bioplex_WMM Guru youn_WMM fraction |
| LSM5 | POLH | 0.409 | 0.568 | bioplex (LSM5) bioplex_WMM |
| LSM5 | LSM1 | 0.353 | 0.539 | bioplex (LSM5) bioplex_WMM youn_WMM |
| LSM2 | PATL1 | 0.161 | 0.416 | youn (LSM2,PATL1) bioplex (PATL1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| LSM6 | AKAP7 | 0.158 | 0.416 | bioplex (LSM6) bioplex_WMM |
| LSM4 | PATL1 | 0.107 | 0.373 | youn (LSM4,PATL1) bioplex (PATL1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| LSM5 | AKAP7 | 0.103 | 0.365 | bioplex (LSM5) bioplex_WMM |
| LSM4 | LSM1 | 0.09 | 0.355 | youn (LSM1,LSM4) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM |
| LSM5 | LSM7 | 0.084 | 0.349 | bioplex (LSM5) bioplex_WMM Guru youn_WMM fraction |
| LSM5 | LSM3 | 0.038 | 0.265 | bioplex (LSM5) bioplex_WMM Guru youn_WMM fraction |
| LSM1 | PATL1 | 0.03 | 0.236 | youn (LSM1,PATL1) bioplex_WMM boldt youn_WMM boldt_WMM |
| LSM8 | AKAP7 | 0.018 | 0.177 | bioplex_WMM WMM_only |
| AKAP7 | LSM3 | 0.017 | 0.173 | bioplex_WMM WMM_only |
| AKAP7 | LSM4 | 0.017 | 0.168 | bioplex_WMM WMM_only |
| LSM2 | AKAP7 | 0.017 | 0.167 | bioplex_WMM WMM_only |
| LSM8 | LSM1 | 0.013 | 0.149 | youn (LSM1) bioplex_WMM youn_WMM |
| AKAP7 | LSM7 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| AKAP7 | LSM1 | 0.012 | 0.144 | bioplex_WMM WMM_only |
| LSM3 | PATL1 | 0.01 | 0.133 | youn (PATL1) bioplex (PATL1) bioplex_WMM youn_WMM gupta_WMM |
| LSM2 | LSM1 | 0.01 | 0.098 | youn (LSM1,LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM8 | PATL1 | 0.009 | 0.096 | youn (PATL1) bioplex_WMM youn_WMM |
| AKAP7 | PATL1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| LSM1 | LSM7 | 0.008 | 0.085 | youn (LSM1) bioplex_WMM youn_WMM treiber_WMM |
| LSM4 | POLH | 0.008 | 0.083 | bioplex_WMM youn_WMM WMM_only |
| POLH | PATL1 | 0.008 | 0.081 | bioplex_WMM youn_WMM WMM_only |
| LSM8 | POLH | 0.008 | 0.067 | bioplex_WMM youn_WMM WMM_only |
| LSM2 | POLH | 0.008 | 0.067 | bioplex_WMM youn_WMM WMM_only |
| POLH | LSM7 | 0.008 | 0.062 | bioplex_WMM youn_WMM WMM_only |
| LSM1 | POLH | 0.008 | 0.044 | bioplex_WMM youn_WMM WMM_only |
| LSM3 | POLH | 0.008 | 0.044 | bioplex_WMM youn_WMM WMM_only |
| LSM6 | POLH | 0.008 | 0.042 | bioplex_WMM youn_WMM WMM_only |
| AKAP7 | POLH | 0.008 | 0.024 | bioplex_WMM WMM_only |
| LSM7 | PATL1 | 0.006 | 0.003 | bioplex (PATL1) bioplex_WMM youn_WMM |
| LSM4 | LSM7 | 0.005 | 0.007 | youn (LSM4) bioplex_WMM Guru youn_WMM fraction boldt_WMM treiber_WMM |
| LSM1 | LSM3 | 0.0 | 0.002 | youn (LSM1) bioplex_WMM Guru youn_WMM fraction |
Images
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Complex HuMAP2_00225 has an average edge precision of 0.432 which is ranked 3011 out of all 6965 complexes.
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