hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00229
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FLNB | Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) | UniProt NCBI |
| SPTAN1 | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | UniProt NCBI |
| SPTBN2 | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | UniProt NCBI |
| AHNAK | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | UniProt NCBI |
| SPTB | Spectrin beta chain, erythrocytic (Beta-I spectrin) | UniProt NCBI |
| SPTBN1 | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008091 | 2.56043303928e-08 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | spectrin |
| REAC:R-HSA-445095 | 2.84195159633e-08 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Interaction between L1 and Ankyrins |
| REAC:R-HSA-375165 | 2.74945671388e-07 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-6807878 | 4.11561600349e-06 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | COPI-mediated anterograde transport |
| REAC:R-HSA-373760 | 7.10312736365e-06 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | L1CAM interactions |
| GO:0015629 | 1.48146606194e-05 | 1.0 | SPTBN1 FLNB AHNAK SPTB SPTAN1 SPTBN2 | actin cytoskeleton |
| REAC:R-HSA-199977 | 2.03020440111e-05 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 3.86525710038e-05 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-5673001 | 6.72471699924e-05 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 7.44706707356e-05 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 9.41651493347e-05 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | FLT3 Signaling |
| REAC:R-HSA-449836 | 0.000126179445512 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.000147417973059 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | MAPK family signaling cascades |
| REAC:R-HSA-1280215 | 0.000199074564606 | 0.833333333333 | SPTAN1 SPTB SPTBN1 FLNB SPTBN2 | Cytokine Signaling in Immune system |
| REAC:R-HSA-446203 | 0.000313242155154 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Asparagine N-linked glycosylation |
| GO:0030864 | 0.000314144203038 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | cortical actin cytoskeleton |
| GO:0003779 | 0.000498298143806 | 0.833333333333 | SPTAN1 SPTB SPTBN1 FLNB SPTBN2 | actin binding |
| GO:0030863 | 0.000700012687215 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | cortical cytoskeleton |
| GO:0045296 | 0.00126792674695 | 0.833333333333 | SPTBN2 SPTAN1 SPTBN1 FLNB AHNAK | cadherin binding |
| REAC:R-HSA-449147 | 0.00316317833645 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Signaling by Interleukins |
| REAC:R-HSA-422475 | 0.00323741737614 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Axon guidance |
| GO:0044448 | 0.00506594708818 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | cell cortex part |
| REAC:R-HSA-373753 | 0.00510333351271 | 0.333333333333 | SPTAN1 SPTBN1 | Nephrin family interactions |
| REAC:R-HSA-199991 | 0.00529378407845 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00654030934977 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Vesicle-mediated transport |
| GO:0050839 | 0.00658952212705 | 0.833333333333 | SPTBN2 SPTAN1 SPTBN1 FLNB AHNAK | cell adhesion molecule binding |
| GO:0007411 | 0.0135624164426 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | axon guidance |
| GO:0097485 | 0.0138763169989 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | neuron projection guidance |
| GO:0006888 | 0.0162282633514 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-168256 | 0.0201098402149 | 0.833333333333 | SPTAN1 SPTB SPTBN1 FLNB SPTBN2 | Immune System |
| GO:0005938 | 0.0222594167129 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | cell cortex |
| REAC:R-HSA-1266738 | 0.0323042935377 | 0.666666666667 | SPTAN1 SPTBN1 SPTB SPTBN2 | Developmental Biology |
| GO:0005856 | 0.0465478032663 | 1.0 | SPTBN1 FLNB AHNAK SPTB SPTAN1 SPTBN2 | cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SPTAN1 | SPTBN1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| SPTAN1 | SPTBN2 | 1.0 | 0.949 | hein_WMM bioplex_WMM fraction boldt_WMM treiber_WMM |
| FLNB | SPTAN1 | 0.571 | 0.655 | hein_WMM bioplex_WMM Guru youn_WMM hein (FLNB) gupta_WMM fraction treiber_WMM |
| FLNB | AHNAK | 0.57 | 0.656 | hein_WMM bioplex_WMM youn_WMM hein (FLNB) gupta_WMM fraction boldt_WMM treiber_WMM |
| SPTAN1 | SPTB | 0.533 | 0.638 | bioplex_WMM fraction |
| FLNB | SPTBN1 | 0.515 | 0.631 | hein_WMM bioplex_WMM youn_WMM hein (FLNB) gupta_WMM fraction boldt_WMM treiber_WMM |
| SPTBN2 | SPTB | 0.007 | 0.003 | bioplex_WMM WMM_only |
| SPTB | SPTBN1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| FLNB | SPTB | 0.007 | 0.0 | bioplex_WMM WMM_only |
| FLNB | SPTBN2 | 0.007 | 0.007 | hein_WMM bioplex_WMM gupta_WMM fraction treiber_WMM |
| SPTAN1 | AHNAK | 0.006 | 0.002 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| SPTBN2 | SPTBN1 | 0.005 | 0.013 | hein_WMM bioplex_WMM WMM_only boldt_WMM treiber_WMM |
| AHNAK | SPTBN1 | 0.003 | 0.016 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| AHNAK | SPTBN2 | 0.003 | 0.016 | hein_WMM bioplex_WMM gupta_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_00229 has an average edge precision of 0.324 which is ranked 4284 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FLNB | HuMAP2_00229 HuMAP2_00921 HuMAP2_04553 |
| SPTAN1 | HuMAP2_00229 HuMAP2_01215 HuMAP2_01488 HuMAP2_01543 HuMAP2_04549 |
| SPTBN2 | HuMAP2_00229 HuMAP2_01488 HuMAP2_05066 |
| AHNAK | HuMAP2_00229 HuMAP2_01849 |
| SPTB | HuMAP2_00229 HuMAP2_01543 HuMAP2_03861 HuMAP2_04964 HuMAP2_06321 |
| SPTBN1 | HuMAP2_00229 HuMAP2_01215 HuMAP2_01488 |