hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00231
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNAS | Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide] | UniProt NCBI |
| MAGED2 | Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) | UniProt NCBI |
| GNAL | Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012049 | 0.00039764290247 | 0.666666666667 | GNAS GNAL | Laryngeal dystonia |
| KEGG:05146 | 0.00159284054118 | 0.666666666667 | GNAS GNAL | Amoebiasis |
| KEGG:05142 | 0.0017077231529 | 0.666666666667 | GNAS GNAL | Chagas disease (American trypanosomiasis) |
| KEGG:04728 | 0.00323398213006 | 0.666666666667 | GNAS GNAL | Dopaminergic synapse |
| WP:WP35 | 0.00357470816736 | 0.666666666667 | GNAS GNAL | G Protein Signaling Pathways |
| WP:WP4540 | 0.00357470816736 | 0.666666666667 | GNAS GNAL | Pathways Regulating Hippo Signaling |
| KEGG:04020 | 0.00558575423654 | 0.666666666667 | GNAS GNAL | Calcium signaling pathway |
| HP:0001618 | 0.0225234057432 | 0.666666666667 | GNAS GNAL | Dysphonia |
| HP:0004373 | 0.0225234057432 | 0.666666666667 | GNAS GNAL | Focal dystonia |
| GO:0007191 | 0.0283955176165 | 0.666666666667 | GNAS GNAL | adenylate cyclase-activating dopamine receptor signaling pathway |
| CORUM:7097 | 0.0499776345577 | 0.333333333333 | GNAS | GNAS-L-GNB1-GNG1 complex |
| CORUM:7143 | 0.0499776345577 | 0.333333333333 | GNAS | GNAS-L-GNB2-GNG1 complex |
| CORUM:7144 | 0.0499776345577 | 0.333333333333 | GNAS | GNAS-L-GNB3-GNG1 complex |
| CORUM:7145 | 0.0499776345577 | 0.333333333333 | GNAS | GNAS-L-GNB4-GNG1 complex |
| CORUM:7146 | 0.0499776345577 | 0.333333333333 | GNAS | GNAS-L-GNB1-GNG1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAS | GNAL | 1.0 | 0.949 | bioplex (GNAS) bioplex_WMM gupta_WMM boldt_WMM |
| GNAS | MAGED2 | 0.993 | 0.918 | bioplex (GNAS,MAGED2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MAGED2 | GNAL | 0.03 | 0.233 | bioplex (MAGED2) bioplex_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_00231 has an average edge precision of 0.7 which is ranked 1370 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNAS | HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032 |
| MAGED2 | HuMAP2_00029 HuMAP2_00231 HuMAP2_01968 HuMAP2_03216 HuMAP2_04904 |
| GNAL | HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032 |