hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00244
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UPP1 | Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | UniProt NCBI |
| AKR1B10 | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | UniProt NCBI |
| HNRNPA1L2 | Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) | UniProt NCBI |
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | UniProt NCBI |
| ARF5 | ADP-ribosylation factor 5 | UniProt NCBI |
| AKR1B15 | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016616 | 3.57543241706e-05 | 0.625 | AKR1B10 AKR1B15 LDHB LDHA IDH3G | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 5.02570571668e-05 | 0.625 | AKR1B10 AKR1B15 LDHB LDHA IDH3G | oxidoreductase activity, acting on CH-OH group of donors |
| REAC:R-HSA-71406 | 0.00039367823385 | 0.375 | LDHB LDHA IDH3G | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:00640 | 0.00675086912227 | 0.25 | LDHA LDHB | Propanoate metabolism |
| KEGG:00620 | 0.00890494757069 | 0.25 | LDHA LDHB | Pyruvate metabolism |
| KEGG:01100 | 0.0101915709661 | 0.625 | AKR1B10 LDHB UPP1 IDH3G LDHA | Metabolic pathways |
| WP:WP534 | 0.0119507998541 | 0.25 | LDHA LDHB | Glycolysis and Gluconeogenesis |
| KEGG:00270 | 0.0124147017773 | 0.25 | LDHA LDHB | Cysteine and methionine metabolism |
| REAC:R-HSA-1428517 | 0.0127263868543 | 0.375 | LDHB LDHA IDH3G | The citric acid (TCA) cycle and respiratory electron transport |
| REAC:R-HSA-1430728 | 0.0157286835681 | 0.75 | AKR1B10 IDH3G AKR1B15 LDHB UPP1 LDHA | Metabolism |
| REAC:R-HSA-70268 | 0.0180422506392 | 0.25 | LDHA LDHB | Pyruvate metabolism |
| KEGG:00010 | 0.0233191717198 | 0.25 | LDHA LDHB | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.0263713562019 | 0.25 | LDHA LDHB | Central carbon metabolism in cancer |
| WP:WP4018 | 0.0395356363713 | 0.25 | LDHA LDHB | Pathways in clear cell renal cell carcinoma |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1B10 | AKR1B15 | 0.998 | 0.939 | bioplex (AKR1B10) bioplex_WMM |
| LDHB | AKR1B15 | 0.709 | 0.728 | fraction |
| LDHA | AKR1B15 | 0.709 | 0.729 | fraction treiber_WMM |
| LDHB | HNRNPA1L2 | 0.429 | 0.577 | youn_WMM gupta_WMM fraction |
| LDHA | HNRNPA1L2 | 0.347 | 0.536 | youn_WMM gupta_WMM fraction |
| LDHA | AKR1B10 | 0.246 | 0.469 | bioplex (AKR1B10) fraction treiber_WMM |
| AKR1B10 | LDHB | 0.241 | 0.468 | bioplex (AKR1B10) fraction treiber_WMM |
| LDHA | LDHB | 0.203 | 0.455 | hein_WMM bioplex (LDHA,LDHB) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| UPP1 | LDHB | 0.112 | 0.38 | fraction treiber_WMM |
| IDH3G | LDHB | 0.068 | 0.349 | bioplex (IDH3G) Guru gupta_WMM fraction |
| UPP1 | LDHA | 0.067 | 0.351 | fraction treiber_WMM |
| ARF5 | AKR1B15 | 0.052 | 0.302 | fraction treiber_WMM |
| HNRNPA1L2 | AKR1B15 | 0.016 | 0.161 | fraction |
| LDHA | IDH3G | 0.007 | 0.0 | bioplex (IDH3G) |
| AKR1B10 | ARF5 | 0.007 | 0.002 | WMM_only treiber_WMM |
| ARF5 | HNRNPA1L2 | 0.006 | 0.005 | youn_WMM fraction |
| UPP1 | ARF5 | 0.004 | 0.01 | fraction treiber_WMM |
| LDHB | ARF5 | 0.004 | 0.015 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| UPP1 | IDH3G | 0.0 | 0.013 | Guru fraction |
| LDHA | ARF5 | 0.0 | 0.011 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| IDH3G | ARF5 | 0.0 | 0.01 | bioplex_WMM Guru fraction |
Images
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Complex HuMAP2_00244 has an average edge precision of 0.31 which is ranked 4454 out of all 6965 complexes.
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