hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00249
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAMP3 | Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208) | UniProt NCBI |
| MARCH5 | E3 ubiquitin-protein ligase MARCH5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCH5) | UniProt NCBI |
| NEK6 | Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | UniProt NCBI |
| NEK7 | Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2980767 | 0.000211071833435 | 0.5 | NEK6 NEK7 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| REAC:R-HSA-3301854 | 0.00497416142364 | 0.5 | NEK6 NEK7 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-2980766 | 0.00991669978918 | 0.5 | NEK6 NEK7 | Nuclear Envelope Breakdown |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NEK6 | NEK7 | 1.0 | 0.949 | bioplex (NEK6) bioplex_WMM boldt boldt_WMM |
| NEK6 | LAMP3 | 0.085 | 0.35 | bioplex (LAMP3) bioplex_WMM |
| LAMP3 | MARCH5 | 0.046 | 0.292 | bioplex (LAMP3) bioplex_WMM |
| LAMP3 | NEK7 | 0.013 | 0.154 | bioplex (LAMP3) bioplex_WMM |
| NEK6 | MARCH5 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| MARCH5 | NEK7 | 0.007 | 0.01 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00249 has an average edge precision of 0.299 which is ranked 4608 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LAMP3 | HuMAP2_00249 HuMAP2_02829 HuMAP2_03845 HuMAP2_05775 |
| MARCH5 | HuMAP2_00249 HuMAP2_02829 HuMAP2_03845 HuMAP2_05127 HuMAP2_05775 |
| NEK6 | HuMAP2_00249 HuMAP2_02829 HuMAP2_03845 HuMAP2_04795 |
| NEK7 | HuMAP2_00249 HuMAP2_03845 HuMAP2_04795 |