hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00251
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EPHB4 | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | UniProt NCBI |
| EFNB2 | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | UniProt NCBI |
| EFNB1 | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | UniProt NCBI |
| EPHB3 | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | UniProt NCBI |
| SDC3 | Syndecan-3 (SYND3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3928664 | 8.6857608829e-10 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | Ephrin signaling |
| REAC:R-HSA-3928662 | 2.99818273785e-08 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | EPHB-mediated forward signaling |
| REAC:R-HSA-3928665 | 5.94611734259e-08 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-2682334 | 7.72111985662e-07 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | EPH-Ephrin signaling |
| KEGG:04360 | 3.42876450157e-06 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | Axon guidance |
| GO:0048013 | 0.000164422098058 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | ephrin receptor signaling pathway |
| WP:WP4561 | 0.000998738671819 | 0.4 | EFNB1 EFNB2 | Cell migration and invasion through p75NTR |
| REAC:R-HSA-422475 | 0.00101311640921 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | Axon guidance |
| WP:WP4564 | 0.00186538306079 | 0.4 | EPHB4 EPHB3 | Neural Crest Cell Migration during Development |
| WP:WP4565 | 0.0022136258273 | 0.4 | EPHB4 EPHB3 | Neural Crest Cell Migration in Cancer |
| REAC:R-HSA-1266738 | 0.0103415798479 | 0.8 | EPHB4 EPHB3 EFNB2 EFNB1 | Developmental Biology |
| MIRNA:hsa-miR-3689f | 0.0258584334602 | 0.4 | EFNB2 SDC3 | hsa-miR-3689f |
| MIRNA:hsa-miR-3689a-5p | 0.0270575118475 | 0.4 | EFNB2 SDC3 | hsa-miR-3689a-5p |
| MIRNA:hsa-miR-3689b-5p | 0.0270575118475 | 0.4 | EFNB2 SDC3 | hsa-miR-3689b-5p |
| MIRNA:hsa-miR-3689e | 0.0270575118475 | 0.4 | EFNB2 SDC3 | hsa-miR-3689e |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EFNB2 | EFNB1 | 1.0 | 0.949 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EFNB2 | SDC3 | 0.903 | 0.827 | bioplex (EFNB2) bioplex_WMM |
| EPHB4 | EFNB2 | 0.679 | 0.708 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EFNB2 | EPHB3 | 0.051 | 0.295 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| SDC3 | EPHB3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| EPHB4 | EPHB3 | 0.008 | 0.044 | bioplex_WMM gupta_WMM WMM_only |
| EPHB4 | SDC3 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| EFNB1 | EPHB3 | 0.008 | 0.031 | bioplex_WMM gupta_WMM WMM_only |
| EFNB1 | SDC3 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| EPHB4 | EFNB1 | 0.007 | 0.0 | bioplex_WMM gupta_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00251 has an average edge precision of 0.301 which is ranked 4582 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EPHB4 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 |
| EFNB2 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |
| EFNB1 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |
| EPHB3 | HuMAP2_00251 HuMAP2_03654 |
| SDC3 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |