hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00272
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNAJC2 | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | UniProt NCBI |
| EIF2A | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | UniProt NCBI |
| HSPA14 | Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) | UniProt NCBI |
| SUMF2 | Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2) | UniProt NCBI |
| DNAJC17 | DnaJ homolog subfamily C member 17 | UniProt NCBI |
| EDF1 | Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1) | UniProt NCBI |
| ZNF598 | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051083 | 0.00676235117068 | 0.333333333333 | HSPA14 DNAJC2 | 'de novo' cotranslational protein folding |
| REAC:R-HSA-3371453 | 0.0455991929544 | 0.333333333333 | HSPA14 DNAJC2 | Regulation of HSF1-mediated heat shock response |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSPA14 | DNAJC2 | 0.967 | 0.877 | hein_WMM bioplex (DNAJC2) bioplex_WMM hein (HSPA14) fraction |
| DNAJC2 | EIF2A | 0.691 | 0.715 | bioplex_WMM gupta_WMM fraction |
| HSPA14 | EIF2A | 0.665 | 0.701 | youn_WMM gupta_WMM fraction |
| DNAJC17 | EIF2A | 0.483 | 0.613 | youn_WMM fraction |
| SUMF2 | DNAJC17 | 0.287 | 0.489 | fraction |
| DNAJC2 | EDF1 | 0.159 | 0.416 | gupta_WMM fraction |
| EDF1 | EIF2A | 0.098 | 0.358 | bioplex_WMM youn_WMM gupta_WMM fraction |
| DNAJC2 | ZNF598 | 0.082 | 0.351 | fraction |
| SUMF2 | DNAJC2 | 0.073 | 0.356 | bioplex_WMM fraction |
| EDF1 | ZNF598 | 0.035 | 0.264 | youn_WMM gupta_WMM fraction |
| HSPA14 | EDF1 | 0.021 | 0.192 | youn_WMM gupta_WMM fraction |
| DNAJC17 | DNAJC2 | 0.01 | 0.101 | fraction |
| EIF2A | ZNF598 | 0.007 | 0.009 | youn_WMM gupta_WMM WMM_only |
| DNAJC17 | ZNF598 | 0.007 | 0.001 | youn_WMM WMM_only |
| HSPA14 | ZNF598 | 0.007 | 0.003 | youn_WMM WMM_only |
| SUMF2 | EDF1 | 0.007 | 0.005 | bioplex_WMM fraction |
| SUMF2 | HSPA14 | 0.0 | 0.009 | fraction |
| DNAJC17 | EDF1 | 0.0 | 0.013 | youn_WMM fraction |
| DNAJC17 | HSPA14 | 0.0 | 0.002 | fraction |
| SUMF2 | EIF2A | 0.0 | 0.0 | bioplex_WMM fraction |
Images
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Complex HuMAP2_00272 has an average edge precision of 0.274 which is ranked 4970 out of all 6965 complexes.
Related Complexes