hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00273
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 (EC 7.1.1.2) (NADH dehydrogenase subunit 4) | UniProt NCBI |
| MT-ND5 | NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) | UniProt NCBI |
| NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit) | UniProt NCBI |
| NDUFB1 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (Complex I-MNLL) (CI-MNLL) (NADH-ubiquinone oxidoreductase MNLL subunit) | UniProt NCBI |
| NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) (Renal carcinoma antigen NY-REN-4) | UniProt NCBI |
| NDUFA8 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) | UniProt NCBI |
| NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 2.54524563761e-16 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Mitochondrial complex I assembly model OXPHOS system |
| WP:WP623 | 3.35078880483e-16 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Oxidative phosphorylation |
| REAC:R-HSA-6799198 | 6.94493729856e-16 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Complex I biogenesis |
| WP:WP111 | 1.56430611079e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0003954 | 1.95885228437e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | NADH dehydrogenase activity |
| GO:0008137 | 1.95885228437e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 1.95885228437e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | NADH dehydrogenase (quinone) activity |
| REAC:R-HSA-611105 | 5.31357736321e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Respiratory electron transport |
| GO:0045271 | 5.94792468276e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | respiratory chain complex I |
| GO:0005747 | 5.94792468276e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial respiratory chain complex I |
| GO:0030964 | 5.94792468276e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | NADH dehydrogenase complex |
| GO:0006120 | 7.04359501906e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial electron transport, NADH to ubiquinone |
| KEGG:00190 | 8.5778733118e-14 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Oxidative phosphorylation |
| CORUM:178 | 9.4175740607e-14 | 0.857142857143 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 NDUFB8 NDUFB1 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:05012 | 1.37368897732e-13 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Parkinson disease |
| KEGG:04723 | 1.91741948695e-13 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Retrograde endocannabinoid signaling |
| GO:0016655 | 2.07653625227e-13 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| REAC:R-HSA-163200 | 2.4204973363e-13 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| GO:0010257 | 6.77157431677e-13 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | NADH dehydrogenase complex assembly |
| GO:0032981 | 6.77157431677e-13 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial respiratory chain complex I assembly |
| GO:0098803 | 1.50472177895e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | respiratory chain complex |
| GO:0005746 | 1.67460972174e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial respirasome |
| GO:0070469 | 2.52899247896e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | respirasome |
| REAC:R-HSA-1428517 | 3.01442992336e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0042775 | 4.10062680412e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 4.49929885452e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | ATP synthesis coupled electron transport |
| KEGG:04714 | 5.08021233854e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Thermogenesis |
| GO:0016651 | 8.34001054984e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | oxidoreductase activity, acting on NAD(P)H |
| GO:1990204 | 9.85356801999e-12 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | oxidoreductase complex |
| GO:0033108 | 1.15966911314e-11 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial respiratory chain complex assembly |
| GO:0022904 | 1.2563082059e-11 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | respiratory electron transport chain |
| GO:0022900 | 1.35976888168e-11 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | electron transport chain |
| GO:0098800 | 6.38660741998e-11 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | inner mitochondrial membrane protein complex |
| GO:0006119 | 8.69474683567e-11 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | oxidative phosphorylation |
| GO:0045333 | 3.40981561528e-10 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | cellular respiration |
| CORUM:2914 | 1.23769432954e-09 | 0.571428571429 | MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Respiratory chain complex I (beta subunit) mitochondrial |
| GO:0044455 | 1.61025758638e-09 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial membrane part |
| GO:0015980 | 3.544948151e-09 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | energy derivation by oxidation of organic compounds |
| GO:0098798 | 1.0806197357e-08 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial protein complex |
| GO:0046034 | 1.18277719085e-08 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | ATP metabolic process |
| KEGG:04932 | 5.71295910475e-08 | 0.714285714286 | NDUFA8 NDUFV3 NDUFS6 NDUFB8 NDUFB1 | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP4396 | 6.73605370288e-08 | 0.714285714286 | NDUFA8 NDUFV3 NDUFS6 NDUFB8 NDUFB1 | Nonalcoholic fatty liver disease |
| KEGG:05010 | 1.19874400465e-07 | 0.714285714286 | NDUFA8 NDUFV3 NDUFS6 NDUFB8 NDUFB1 | Alzheimer disease |
| GO:0005743 | 2.23154164542e-07 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial inner membrane |
| KEGG:05016 | 2.35070471957e-07 | 0.714285714286 | NDUFA8 NDUFV3 NDUFS6 NDUFB8 NDUFB1 | Huntington disease |
| GO:0006091 | 3.03570543251e-07 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | generation of precursor metabolites and energy |
| GO:0019866 | 3.86088683525e-07 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | organelle inner membrane |
| CORUM:2948 | 5.57055794781e-07 | 0.428571428571 | NDUFS6 NDUFB8 NDUFV3 | Respiratory chain complex I (incomplete intermediate), mitochondrial |
| GO:0007005 | 7.46193697653e-07 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrion organization |
| GO:0055114 | 1.15069587692e-06 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | oxidation-reduction process |
| KEGG:01100 | 1.82723672184e-06 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Metabolic pathways |
| GO:0031966 | 1.97210997129e-06 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial membrane |
| GO:0005740 | 3.12357485887e-06 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial envelope |
| GO:0016491 | 5.38547105243e-06 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | oxidoreductase activity |
| HP:0030085 | 1.12079706705e-05 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormal CSF lactate level |
| HP:0002490 | 1.12079706705e-05 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Increased CSF lactate |
| HP:0025454 | 2.28690126279e-05 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormal CSF metabolite level |
| GO:0044429 | 5.86181680769e-05 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrial part |
| GO:0031975 | 7.6116924814e-05 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | envelope |
| GO:0031967 | 7.6116924814e-05 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | organelle envelope |
| REAC:R-HSA-1430728 | 8.36020973003e-05 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | Metabolism |
| GO:0034622 | 9.47308498967e-05 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | cellular protein-containing complex assembly |
| GO:0098796 | 0.000109791923192 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | membrane protein complex |
| HP:0003737 | 0.000848260672904 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Mitochondrial myopathy |
| HP:0001138 | 0.000848260672904 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Optic neuropathy |
| HP:0001639 | 0.00092066541512 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Hypertrophic cardiomyopathy |
| GO:0005739 | 0.000929815577583 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | mitochondrion |
| GO:1902494 | 0.00105300999874 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | catalytic complex |
| CORUM:2920 | 0.00120480805051 | 0.285714285714 | NDUFS6 NDUFV3 | Respiratory chain complex I (lambda subunit) mitochondrial |
| HP:0003800 | 0.00167216688693 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Muscle abnormality related to mitochondrial dysfunction |
| CORUM:0000000 | 0.00178557880024 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | CORUM root |
| HP:0004372 | 0.00215959234857 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Reduced consciousness/confusion |
| HP:0000091 | 0.00218536926552 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Abnormal renal tubule morphology |
| HP:0003648 | 0.0024218379091 | 0.285714285714 | MT-ND5 MT-ND4 | Lacticaciduria |
| HP:0008947 | 0.00257978907368 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Infantile muscular hypotonia |
| HP:0001941 | 0.00267758979755 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Acidosis |
| GO:0065003 | 0.00271911942712 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | protein-containing complex assembly |
| HP:0002793 | 0.00307082516316 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormal pattern of respiration |
| HP:0100611 | 0.00322839434563 | 0.285714285714 | MT-ND5 MT-ND4 | Multiple glomerular cysts |
| HP:0004360 | 0.00378730054633 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormality of acid-base homeostasis |
| HP:0003572 | 0.00414986351758 | 0.285714285714 | MT-ND5 MT-ND4 | Low plasma citrulline |
| HP:0031546 | 0.00478131901878 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Cardiac conduction abnormality |
| HP:0001112 | 0.0051861681154 | 0.285714285714 | MT-ND5 MT-ND4 | Leber optic atrophy |
| HP:0007768 | 0.0051861681154 | 0.285714285714 | MT-ND5 MT-ND4 | Central retinal vessel vascular tortuosity |
| HP:0000631 | 0.0051861681154 | 0.285714285714 | MT-ND5 MT-ND4 | Retinal arterial tortuosity |
| HP:0011965 | 0.0063372308607 | 0.285714285714 | MT-ND5 MT-ND4 | Abnormal circulating citrulline concentration |
| HP:0000725 | 0.0063372308607 | 0.285714285714 | MT-ND5 MT-ND4 | Psychotic episodes |
| HP:0000576 | 0.0063372308607 | 0.285714285714 | MT-ND5 MT-ND4 | Centrocecal scotoma |
| HP:0012447 | 0.00778237757503 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormal myelination |
| HP:0004885 | 0.00898332183607 | 0.285714285714 | MT-ND5 MT-ND4 | Episodic respiratory distress |
| HP:0002921 | 0.00937613076412 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormality of the cerebrospinal fluid |
| GO:0016310 | 0.0100383435656 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | phosphorylation |
| GO:0043933 | 0.0102104607424 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | protein-containing complex subunit organization |
| HP:0001638 | 0.0103597077393 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Cardiomyopathy |
| HP:0003287 | 0.0103685612154 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Abnormality of mitochondrial metabolism |
| HP:0000816 | 0.0104781956652 | 0.285714285714 | MT-ND5 MT-ND4 | Abnormality of Krebs cycle metabolism |
| HP:0003481 | 0.0104781956652 | 0.285714285714 | MT-ND5 MT-ND4 | Segmental peripheral demyelination/remyelination |
| HP:0002401 | 0.0104781956652 | 0.285714285714 | MT-ND5 MT-ND4 | Stroke-like episode |
| HP:0001644 | 0.0117314228717 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Dilated cardiomyopathy |
| HP:0001637 | 0.0125539445768 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormal myocardium morphology |
| HP:0002093 | 0.0136462255833 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Respiratory insufficiency |
| HP:0005116 | 0.0138112142376 | 0.285714285714 | MT-ND5 MT-ND4 | Arterial tortuosity |
| HP:0007763 | 0.0138112142376 | 0.285714285714 | MT-ND5 MT-ND4 | Retinal telangiectasia |
| HP:0200125 | 0.0156492047667 | 0.285714285714 | MT-ND5 MT-ND4 | Mitochondrial respiratory chain defects |
| HP:0004948 | 0.0156492047667 | 0.285714285714 | MT-ND5 MT-ND4 | Vascular tortuosity |
| HP:0001716 | 0.0156492047667 | 0.285714285714 | MT-ND5 MT-ND4 | Wolff-Parkinson-White syndrome |
| HP:0031434 | 0.017601413367 | 0.285714285714 | MT-ND5 MT-ND4 | Abnormal speech prosody |
| HP:0012103 | 0.0176082521898 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Abnormality of the mitochondrion |
| HP:0002151 | 0.0199289601625 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Increased serum lactate |
| HP:0003128 | 0.0207451194397 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Lactic acidosis |
| HP:0002572 | 0.0218481766952 | 0.285714285714 | MT-ND5 MT-ND4 | Episodic vomiting |
| HP:0004309 | 0.0218481766952 | 0.285714285714 | MT-ND5 MT-ND4 | Ventricular preexcitation |
| HP:0002098 | 0.0233252077163 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Respiratory distress |
| HP:0007420 | 0.0241425774578 | 0.285714285714 | MT-ND5 MT-ND4 | Spontaneous hematomas |
| HP:0002134 | 0.0261084478552 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Abnormality of the basal ganglia |
| HP:0012211 | 0.026503020773 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormal renal physiology |
| HP:0002045 | 0.0265508883611 | 0.285714285714 | MT-ND5 MT-ND4 | Hypothermia |
| HP:0001410 | 0.02757854618 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Decreased liver function |
| HP:0000508 | 0.0279634171889 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Ptosis |
| HP:0001635 | 0.0280804313779 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Congestive heart failure |
| HP:0007924 | 0.0290730325003 | 0.285714285714 | MT-ND5 MT-ND4 | Slow decrease in visual acuity |
| HP:0025155 | 0.029102183295 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Abnormality of hepatobiliary system physiology |
| HP:0012795 | 0.029482433693 | 0.571428571429 | NDUFS6 NDUFB8 MT-ND5 MT-ND4 | Abnormality of the optic disc |
| HP:0012575 | 0.029622117541 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Abnormal nephron morphology |
| HP:0100660 | 0.0312185579762 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Dyskinesia |
| HP:0002883 | 0.0317089330016 | 0.285714285714 | MT-ND5 MT-ND4 | Hyperventilation |
| HP:0002072 | 0.0317630295579 | 0.428571428571 | MT-ND5 NDUFB8 MT-ND4 | Chorea |
| HP:0002578 | 0.0344585130221 | 0.285714285714 | MT-ND5 MT-ND4 | Gastroparesis |
| HP:0002483 | 0.0344585130221 | 0.285714285714 | MT-ND5 MT-ND4 | Bulbar signs |
| HP:0000622 | 0.0344585130221 | 0.285714285714 | MT-ND5 MT-ND4 | Blurred vision |
| HP:0002647 | 0.0373216957502 | 0.285714285714 | MT-ND5 MT-ND4 | Aortic dissection |
| WP:000000 | 0.0394625231882 | 1.0 | NDUFA8 NDUFV3 NDUFS6 MT-ND5 MT-ND4 NDUFB8 NDUFB1 | WIKIPATHWAYS |
| HP:0001427 | 0.0402984044053 | 0.285714285714 | MT-ND5 MT-ND4 | Mitochondrial inheritance |
| HP:0002013 | 0.0406950613881 | 0.428571428571 | NDUFS6 MT-ND4 MT-ND5 | Vomiting |
| HP:0100651 | 0.0433885622377 | 0.285714285714 | MT-ND5 MT-ND4 | Type I diabetes mellitus |
| HP:0003348 | 0.0433885622377 | 0.285714285714 | MT-ND5 MT-ND4 | Hyperalaninemia |
| HP:0010916 | 0.0433885622377 | 0.285714285714 | MT-ND5 MT-ND4 | Abnormal circulating alanine concentration |
| HP:0010915 | 0.0433885622377 | 0.285714285714 | MT-ND5 MT-ND4 | Abnormal circulating pyruvate family amino acid concentration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NDUFV3 | NDUFA8 | 0.856 | 0.793 | bioplex (NDUFA8) bioplex_WMM |
| MT-ND4 | NDUFA8 | 0.383 | 0.551 | bioplex (NDUFA8) bioplex_WMM |
| NDUFA8 | MT-ND5 | 0.323 | 0.512 | bioplex (NDUFA8) bioplex_WMM |
| NDUFV3 | NDUFS6 | 0.219 | 0.466 | bioplex (NDUFS6) bioplex_WMM youn_WMM |
| NDUFB8 | NDUFA8 | 0.171 | 0.429 | hein_WMM bioplex (NDUFA8) bioplex_WMM |
| NDUFA8 | NDUFS6 | 0.154 | 0.414 | hein_WMM bioplex (NDUFA8,NDUFS6) bioplex_WMM boldt_WMM |
| NDUFB8 | NDUFS6 | 0.114 | 0.385 | hein_WMM bioplex (NDUFS6) bioplex_WMM |
| NDUFS6 | MT-ND5 | 0.109 | 0.373 | bioplex (NDUFS6) bioplex_WMM |
| MT-ND4 | NDUFS6 | 0.093 | 0.355 | bioplex (NDUFS6) bioplex_WMM |
| NDUFB1 | NDUFA8 | 0.084 | 0.348 | hein_WMM bioplex (NDUFA8) bioplex_WMM |
| NDUFB1 | NDUFS6 | 0.035 | 0.261 | hein_WMM bioplex (NDUFS6) bioplex_WMM |
| NDUFB8 | MT-ND5 | 0.021 | 0.187 | bioplex_WMM WMM_only |
| NDUFB8 | NDUFB1 | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| NDUFB8 | MT-ND4 | 0.015 | 0.151 | bioplex_WMM WMM_only |
| NDUFB1 | MT-ND4 | 0.015 | 0.142 | bioplex_WMM WMM_only |
| MT-ND4 | MT-ND5 | 0.014 | 0.136 | bioplex_WMM WMM_only |
| NDUFV3 | MT-ND4 | 0.012 | 0.154 | bioplex_WMM WMM_only |
| NDUFB8 | NDUFV3 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| NDUFB1 | MT-ND5 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| NDUFV3 | MT-ND5 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| NDUFB1 | NDUFV3 | 0.01 | 0.141 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00273 has an average edge precision of 0.305 which is ranked 4503 out of all 6965 complexes.
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