hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00275
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NIP7 | 60S ribosome subunit biogenesis protein NIP7 homolog (KD93) | UniProt NCBI |
| RRP15 | RRP15-like protein (Ribosomal RNA-processing protein 15) | UniProt NCBI |
| RRS1 | Ribosome biogenesis regulatory protein homolog | UniProt NCBI |
| BRIX1 | Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) | UniProt NCBI |
| LLPH | Protein LLP homolog (Protein LAPS18-like) | UniProt NCBI |
| SURF6 | Surfeit locus protein 6 | UniProt NCBI |
| EBNA1BP2 | Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) | UniProt NCBI |
| DKC1 | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) | UniProt NCBI |
| NOP56 | Nucleolar protein 56 (Nucleolar protein 5A) | UniProt NCBI |
| RPF2 | Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog) | UniProt NCBI |
| DDX24 | ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0042254 | 2.70170739052e-08 | 0.727272727273 | SURF6 BRIX1 NOP56 RPF2 EBNA1BP2 DKC1 RRS1 NIP7 | ribosome biogenesis |
| GO:0005730 | 5.13000068247e-08 | 0.909090909091 | LLPH SURF6 BRIX1 NOP56 DDX24 RPF2 EBNA1BP2 DKC1 RRS1 NIP7 | nucleolus |
| GO:0042273 | 1.01938226071e-07 | 0.545454545455 | SURF6 BRIX1 EBNA1BP2 RPF2 RRS1 NIP7 | ribosomal large subunit biogenesis |
| GO:0022613 | 1.04048960204e-06 | 0.727272727273 | SURF6 BRIX1 NOP56 RPF2 EBNA1BP2 DKC1 RRS1 NIP7 | ribonucleoprotein complex biogenesis |
| GO:0003723 | 3.22704440191e-05 | 0.909090909091 | LLPH SURF6 BRIX1 NOP56 DDX24 RPF2 EBNA1BP2 DKC1 RRS1 NIP7 | RNA binding |
| GO:0030684 | 5.55613333118e-05 | 0.454545454545 | RRS1 NOP56 RRP15 EBNA1BP2 NIP7 | preribosome |
| GO:0030687 | 7.07796251557e-05 | 0.363636363636 | RRS1 RRP15 EBNA1BP2 NIP7 | preribosome, large subunit precursor |
| REAC:R-HSA-8868773 | 0.00176775233438 | 0.363636363636 | DKC1 NIP7 NOP56 EBNA1BP2 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.00216328053202 | 0.363636363636 | DKC1 NIP7 NOP56 EBNA1BP2 | rRNA processing |
| CORUM:3055 | 0.00334529445417 | 0.272727272727 | BRIX1 NOP56 EBNA1BP2 | Nop56p-associated pre-rRNA complex |
| GO:0006364 | 0.00435660994076 | 0.454545454545 | RRS1 RPF2 EBNA1BP2 NOP56 DKC1 | rRNA processing |
| GO:0016072 | 0.00561324734791 | 0.454545454545 | RRS1 RPF2 EBNA1BP2 NOP56 DKC1 | rRNA metabolic process |
| GO:0003676 | 0.00902997612677 | 0.909090909091 | LLPH SURF6 BRIX1 NOP56 DDX24 RPF2 EBNA1BP2 DKC1 RRS1 NIP7 | nucleic acid binding |
| TF:M08213_1 | 0.0128220513548 | 0.727272727273 | NIP7 BRIX1 RPF2 RRP15 SURF6 DKC1 RRS1 EBNA1BP2 | Factor: Elk-1:TBR2; motif: TNRCACCGGAAGN; match class: 1 |
| TF:M08913_1 | 0.01357720109 | 0.909090909091 | LLPH NIP7 BRIX1 DDX24 RPF2 RRP15 SURF6 DKC1 RRS1 EBNA1BP2 | Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 |
| TF:M02071_1 | 0.0146217460617 | 1.0 | LLPH NIP7 BRIX1 NOP56 DDX24 RPF2 RRP15 SURF6 DKC1 RRS1 EBNA1BP2 | Factor: ETV7; motif: NCCGGAANNN; match class: 1 |
| TF:M03977_1 | 0.0228457922089 | 1.0 | LLPH NIP7 BRIX1 NOP56 DDX24 RPF2 RRP15 SURF6 DKC1 RRS1 EBNA1BP2 | Factor: ETS1; motif: ACCGGAARYN; match class: 1 |
| TF:M00025_1 | 0.0230374310655 | 1.0 | LLPH NIP7 BRIX1 NOP56 DDX24 RPF2 RRP15 SURF6 DKC1 RRS1 EBNA1BP2 | Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 |
| TF:M08231_1 | 0.024547978646 | 0.727272727273 | NIP7 BRIX1 DDX24 RPF2 RRP15 DKC1 RRS1 EBNA1BP2 | Factor: Elk-1:T-bet; motif: TCACACCGGAAGNN; match class: 1 |
| GO:0000027 | 0.0386015928356 | 0.272727272727 | RRS1 BRIX1 RPF2 | ribosomal large subunit assembly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RRS1 | RPF2 | 1.0 | 0.949 | bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| BRIX1 | EBNA1BP2 | 1.0 | 0.949 | hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| RRS1 | EBNA1BP2 | 0.999 | 0.949 | bioplex (EBNA1BP2,RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| EBNA1BP2 | RPF2 | 0.998 | 0.939 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| DKC1 | NOP56 | 0.997 | 0.929 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RRP15 | EBNA1BP2 | 0.986 | 0.9 | hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| DKC1 | EBNA1BP2 | 0.985 | 0.899 | hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| BRIX1 | RPF2 | 0.98 | 0.896 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| EBNA1BP2 | LLPH | 0.979 | 0.895 | bioplex_WMM youn_WMM fraction treiber_WMM |
| RRS1 | BRIX1 | 0.973 | 0.886 | bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| DKC1 | BRIX1 | 0.973 | 0.886 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| NIP7 | EBNA1BP2 | 0.971 | 0.883 | hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM treiber_WMM |
| EBNA1BP2 | NOP56 | 0.968 | 0.88 | hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM |
| RRP15 | NOP56 | 0.962 | 0.87 | hein_WMM bioplex_WMM youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM |
| DKC1 | RRS1 | 0.961 | 0.869 | bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| BRIX1 | LLPH | 0.958 | 0.863 | bioplex_WMM youn_WMM fraction |
| BRIX1 | NOP56 | 0.956 | 0.862 | hein_WMM bioplex_WMM youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM |
| DKC1 | RPF2 | 0.948 | 0.856 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| DKC1 | RRP15 | 0.947 | 0.857 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RRS1 | DDX24 | 0.943 | 0.856 | bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM fraction |
| EBNA1BP2 | DDX24 | 0.932 | 0.846 | hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RRP15 | NIP7 | 0.92 | 0.844 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| NOP56 | DDX24 | 0.809 | 0.77 | hein_WMM bioplex_WMM Guru youn_WMM hein (NOP56) gupta_WMM fraction treiber_WMM |
| DKC1 | DDX24 | 0.766 | 0.749 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| SURF6 | EBNA1BP2 | 0.758 | 0.747 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| RRP15 | RRS1 | 0.745 | 0.74 | bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| SURF6 | RPF2 | 0.598 | 0.668 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| LLPH | RPF2 | 0.495 | 0.62 | bioplex_WMM youn_WMM fraction treiber_WMM |
| RRP15 | RPF2 | 0.493 | 0.621 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| SURF6 | DKC1 | 0.489 | 0.617 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RRS1 | LLPH | 0.463 | 0.6 | bioplex_WMM youn_WMM fraction treiber_WMM |
| BRIX1 | DDX24 | 0.448 | 0.592 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| SURF6 | BRIX1 | 0.447 | 0.59 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| DDX24 | RPF2 | 0.429 | 0.577 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RRP15 | DDX24 | 0.396 | 0.556 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SURF6 | RRS1 | 0.388 | 0.551 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| NIP7 | RRS1 | 0.38 | 0.549 | bioplex (RRS1) bioplex_WMM youn_WMM treiber_WMM |
| SURF6 | LLPH | 0.277 | 0.485 | bioplex_WMM youn_WMM fraction |
| NIP7 | NOP56 | 0.24 | 0.468 | hein_WMM bioplex_WMM youn_WMM hein (NOP56) treiber_WMM |
| NIP7 | DDX24 | 0.23 | 0.467 | hein_WMM bioplex_WMM youn_WMM fraction |
| RRP15 | BRIX1 | 0.186 | 0.441 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| DKC1 | LLPH | 0.112 | 0.38 | bioplex_WMM youn_WMM fraction |
| NIP7 | BRIX1 | 0.078 | 0.353 | hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM |
| NIP7 | RPF2 | 0.046 | 0.292 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| SURF6 | RRP15 | 0.034 | 0.262 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| RRS1 | NOP56 | 0.03 | 0.238 | bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| NOP56 | RPF2 | 0.03 | 0.23 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| NIP7 | LLPH | 0.022 | 0.195 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| SURF6 | DDX24 | 0.017 | 0.173 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| LLPH | DDX24 | 0.014 | 0.136 | bioplex_WMM youn_WMM WMM_only |
| SURF6 | NIP7 | 0.014 | 0.139 | hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM |
| RRP15 | LLPH | 0.01 | 0.131 | bioplex_WMM youn_WMM WMM_only |
| DKC1 | NIP7 | 0.01 | 0.105 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| SURF6 | NOP56 | 0.004 | 0.011 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| NOP56 | LLPH | 0.003 | 0.015 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_00275 has an average edge precision of 0.611 which is ranked 1884 out of all 6965 complexes.
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