hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00278
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDIA3 | Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) | UniProt NCBI |
| JMJD8 | JmjC domain-containing protein 8 (Jumonji domain-containing protein 8) | UniProt NCBI |
| CALR | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) | UniProt NCBI |
| INHA | Inhibin alpha chain | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04612 | 0.00285390492132 | 0.5 | CALR PDIA3 | Antigen processing and presentation |
| REAC:R-HSA-983170 | 0.00301045354831 | 0.5 | CALR PDIA3 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-901042 | 0.00326103241616 | 0.5 | CALR PDIA3 | Calnexin/calreticulin cycle |
| REAC:R-HSA-532668 | 0.00596538345738 | 0.5 | CALR PDIA3 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| KEGG:04141 | 0.0241976216174 | 0.5 | CALR PDIA3 | Protein processing in endoplasmic reticulum |
| CORUM:5217 | 0.0249595281251 | 0.25 | CALR | Calreticulin homo-oligomer complex |
| KEGG:05169 | 0.0328286642151 | 0.5 | CALR PDIA3 | Epstein-Barr virus infection |
| REAC:R-HSA-1236974 | 0.0331557329305 | 0.5 | CALR PDIA3 | ER-Phagosome pathway |
| KEGG:05170 | 0.0387812861874 | 0.5 | CALR PDIA3 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0399515654372 | 0.5 | CALR PDIA3 | Human cytomegalovirus infection |
| GO:0042824 | 0.0405595771497 | 0.5 | CALR PDIA3 | MHC class I peptide loading complex |
| REAC:R-HSA-1236975 | 0.0435915557177 | 0.5 | CALR PDIA3 | Antigen processing-Cross presentation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CALR | PDIA3 | 0.438 | 0.583 | bioplex (PDIA3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PDIA3 | INHA | 0.131 | 0.402 | bioplex (INHA) bioplex_WMM |
| CALR | INHA | 0.09 | 0.354 | bioplex (INHA) bioplex_WMM |
| PDIA3 | JMJD8 | 0.054 | 0.301 | bioplex (PDIA3) bioplex_WMM |
| CALR | JMJD8 | 0.006 | 0.007 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00278 has an average edge precision of 0.329 which is ranked 4228 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDIA3 | HuMAP2_00278 HuMAP2_01152 HuMAP2_04961 HuMAP2_05341 |
| JMJD8 | HuMAP2_00278 HuMAP2_04961 |
| CALR | HuMAP2_00278 HuMAP2_01351 HuMAP2_05426 HuMAP2_05943 |
| INHA | HuMAP2_00278 HuMAP2_01351 HuMAP2_04961 |