hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00283

Confidence: Medium

Genename	Protein Name	Links
BAK1	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)	UniProt NCBI
MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)	UniProt NCBI
BAX	Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)	UniProt NCBI
BCL2L12	Bcl-2-like protein 12 (Bcl2-L-12) (Bcl-2-related proline-rich protein)	UniProt NCBI
BBC3	Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis)	UniProt NCBI
PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP254	6.07820774446e-10	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	Apoptosis
WP:WP1772	1.03635102909e-09	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	Apoptosis Modulation and Signaling
WP:WP3872	1.46272770016e-09	0.666666666667	BAK1 BCL2L12 MCL1 BAX	Regulation of Apoptosis by Parathyroid Hormone-related Protein
KEGG:04215	9.25963649198e-09	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Apoptosis - multiple species
KEGG:04210	1.06019966074e-08	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	Apoptosis
WP:WP3614	1.23366697315e-08	0.666666666667	PMAIP1 BAK1 MCL1 BAX	Photodynamic therapy-induced HIF-1 survival signaling
REAC:R-HSA-109606	2.74945671388e-07	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Intrinsic Pathway for Apoptosis
WP:WP4216	2.91734422325e-07	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Chromosomal and microsatellite instability in colorectal cancer
KEGG:01524	3.46039792527e-07	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Platinum drug resistance
KEGG:05210	5.87672777293e-07	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Colorectal cancer
WP:WP1742	1.01861297007e-06	0.5	BAX BBC3 PMAIP1	TP53 Network
WP:WP710	1.37568401472e-06	0.666666666667	PMAIP1 BAK1 BBC3 BAX	DNA Damage Response (only ATM dependent)
WP:WP3982	2.30511528619e-06	0.5	BAX BBC3 PMAIP1	miRNA regulation of p53 pathway in prostate cancer
GO:2001235	5.44729960606e-06	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	positive regulation of apoptotic signaling pathway
REAC:R-HSA-6803204	6.77163692478e-06	0.5	BAX BBC3 PMAIP1	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
CORUM:5823	8.39001385941e-06	0.333333333333	BAK1 MCL1	MCL1-BAK1 complex
GO:0005741	1.01218111583e-05	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	mitochondrial outer membrane
GO:1905898	1.49273703752e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of response to endoplasmic reticulum stress
GO:1901030	1.49273703752e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0031968	1.50954592172e-05	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	organelle outer membrane
GO:0019867	1.56842414157e-05	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	outer membrane
WP:WP3611	2.41794273383e-05	0.5	BAK1 MCL1 BAX	Photodynamic therapy-induced AP-1 survival signaling.
GO:2001244	2.99853000209e-05	0.666666666667	PMAIP1 BAX MCL1 BBC3	positive regulation of intrinsic apoptotic signaling pathway
GO:1901028	2.99853000209e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0097136	3.63109651748e-05	0.5	BAK1 MCL1 BAX	Bcl-2 family protein complex
REAC:R-HSA-109581	3.86525710038e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Apoptosis
REAC:R-HSA-5357801	4.14836354799e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Programmed Cell Death
GO:0001836	4.49707918505e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	release of cytochrome c from mitochondria
GO:0070059	4.49707918505e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000116	5.11490390245e-05	0.833333333333	PMAIP1 BAK1 BBC3 BCL2L12 BAX	regulation of cysteine-type endopeptidase activity
REAC:R-HSA-5633008	5.85102183028e-05	0.5	BAX BBC3 PMAIP1	TP53 Regulates Transcription of Cell Death Genes
KEGG:04115	6.94278084771e-05	0.5	BAX BBC3 PMAIP1	p53 signaling pathway
GO:0097345	7.08670803224e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	mitochondrial outer membrane permeabilization
WP:WP707	7.12187442815e-05	0.5	BAX BBC3 PMAIP1	DNA Damage Response
WP:WP1530	8.13431193589e-05	0.5	BAX BBC3 PMAIP1	miRNA Regulation of DNA Damage Response
GO:1902110	8.38584297733e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686	9.85570254489e-05	0.666666666667	PMAIP1 BAK1 BBC3 BAX	mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903896	0.000101639975642	0.5	BAK1 BBC3 BAX	positive regulation of IRE1-mediated unfolded protein response
GO:0035794	0.000106591013601	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of mitochondrial membrane permeability
GO:1902108	0.000106591013601	0.666666666667	PMAIP1 BAK1 BBC3 BAX	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1905710	0.000115105893408	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of membrane permeability
GO:0097193	0.000123270937374	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	intrinsic apoptotic signaling pathway
GO:0046902	0.000154355035659	0.666666666667	PMAIP1 BAK1 BBC3 BAX	regulation of mitochondrial membrane permeability
REAC:R-HSA-111457	0.000221597343492	0.333333333333	BAK1 BAX	Release of apoptotic factors from the mitochondria
GO:0090559	0.000246130343849	0.666666666667	PMAIP1 BAK1 BBC3 BAX	regulation of membrane permeability
GO:0052548	0.000308640170666	0.833333333333	PMAIP1 BAK1 BBC3 BCL2L12 BAX	regulation of endopeptidase activity
GO:1905897	0.000333147323349	0.666666666667	PMAIP1 BAK1 BBC3 BAX	regulation of response to endoplasmic reticulum stress
GO:2001233	0.000371392762282	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	regulation of apoptotic signaling pathway
GO:1903894	0.00039905855691	0.5	BAK1 BBC3 BAX	regulation of IRE1-mediated unfolded protein response
GO:0052547	0.000452658305655	0.833333333333	PMAIP1 BAK1 BBC3 BCL2L12 BAX	regulation of peptidase activity
GO:1900103	0.000518697707158	0.5	BAK1 BBC3 BAX	positive regulation of endoplasmic reticulum unfolded protein response
GO:0032461	0.000518697707158	0.5	BAX BBC3 PMAIP1	positive regulation of protein oligomerization
KEGG:05162	0.000563363106539	0.5	BAK1 BBC3 BAX	Measles
WP:WP4396	0.000616654381616	0.5	BAK1 BBC3 BAX	Nonalcoholic fatty liver disease
KEGG:05200	0.000619708787865	0.666666666667	PMAIP1 BAK1 BBC3 BAX	Pathways in cancer
REAC:R-HSA-111453	0.000797179114843	0.333333333333	BBC3 PMAIP1	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
WP:WP2507	0.000952765433858	0.333333333333	BAK1 BAX	Nanomaterial induced apoptosis
GO:0008637	0.000968898210955	0.666666666667	PMAIP1 BAK1 BBC3 BAX	apoptotic mitochondrial changes
GO:0010822	0.00130853702278	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of mitochondrion organization
KEGG:05203	0.0017821830589	0.5	BAK1 PMAIP1 BAX	Viral carcinogenesis
GO:0007006	0.00201287714577	0.666666666667	PMAIP1 BAK1 BBC3 BAX	mitochondrial membrane organization
MIRNA:hsa-miR-125b-5p	0.00202843262423	0.666666666667	PMAIP1 BAK1 MCL1 BBC3	hsa-miR-125b-5p
GO:0043525	0.00206534926206	0.5	BAX MCL1 BBC3	positive regulation of neuron apoptotic process
GO:0032469	0.00206534926206	0.5	BAK1 BBC3 BAX	endoplasmic reticulum calcium ion homeostasis
GO:2001242	0.00208860909913	0.666666666667	PMAIP1 BAX MCL1 BBC3	regulation of intrinsic apoptotic signaling pathway
GO:2001056	0.00232863701025	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of cysteine-type endopeptidase activity
GO:0042981	0.00262950990204	1.0	BAK1 BCL2L12 BBC3 BAX MCL1 PMAIP1	regulation of apoptotic process
REAC:R-HSA-111471	0.00265393377546	0.333333333333	BAK1 BAX	Apoptotic factor-mediated response
GO:1900101	0.00278918949629	0.5	BAK1 BBC3 BAX	regulation of endoplasmic reticulum unfolded protein response
GO:0032459	0.00278918949629	0.5	BAX BBC3 PMAIP1	regulation of protein oligomerization
GO:0090200	0.00278918949629	0.5	BAX BBC3 PMAIP1	positive regulation of release of cytochrome c from mitochondria
GO:0043067	0.00293782814438	1.0	BAK1 BCL2L12 BBC3 BAX MCL1 PMAIP1	regulation of programmed cell death
GO:0097190	0.00305393756634	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	apoptotic signaling pathway
GO:0010950	0.00397477358415	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of endopeptidase activity
KEGG:05216	0.00414404804148	0.333333333333	BAK1 BAX	Thyroid cancer
GO:0043065	0.00430914744721	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	positive regulation of apoptotic process
GO:0043068	0.0046371909663	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	positive regulation of programmed cell death
GO:0097191	0.00477442110408	0.666666666667	PMAIP1 BAK1 MCL1 BAX	extrinsic apoptotic signaling pathway
GO:0010952	0.00491856836288	0.666666666667	PMAIP1 BAK1 BBC3 BAX	positive regulation of peptidase activity
WP:WP1971	0.0050096749716	0.333333333333	BAX BBC3	Integrated Cancer Pathway
GO:0010941	0.00505801329557	1.0	BAK1 BCL2L12 BBC3 BAX MCL1 PMAIP1	regulation of cell death
GO:0010821	0.00506594708818	0.666666666667	PMAIP1 BAK1 BBC3 BAX	regulation of mitochondrion organization
GO:0001844	0.00661098268806	0.5	BAX BBC3 PMAIP1	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0097145	0.00676235117068	0.333333333333	BAK1 BAX	BAK complex
GO:0010248	0.00676235117068	0.333333333333	BAK1 BAX	establishment or maintenance of transmembrane electrochemical gradient
GO:0043281	0.006914256367	0.666666666667	PMAIP1 BAX BCL2L12 BBC3	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010942	0.00704880676626	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	positive regulation of cell death
WP:WP3959	0.00822079355503	0.333333333333	BAK1 BAX	DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM
GO:0006915	0.00907418198713	1.0	BAK1 BCL2L12 BBC3 BAX MCL1 PMAIP1	apoptotic process
GO:0030162	0.00934337825213	0.833333333333	PMAIP1 BAK1 BBC3 BCL2L12 BAX	regulation of proteolysis
KEGG:05217	0.00954974409847	0.333333333333	BAK1 BAX	Basal cell carcinoma
REAC:R-HSA-114452	0.00959640616298	0.333333333333	BBC3 PMAIP1	Activation of BH3-only proteins
KEGG:05213	0.00989523261713	0.333333333333	BAK1 BAX	Endometrial cancer
WP:WP4155	0.0104552288042	0.333333333333	BAK1 BAX	Endometrial cancer
GO:0090199	0.0108183376095	0.5	BAX BBC3 PMAIP1	regulation of release of cytochrome c from mitochondria
GO:0031966	0.0109160303478	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	mitochondrial membrane
KEGG:05218	0.0117137285677	0.333333333333	BAK1 BAX	Melanoma
KEGG:05223	0.0124835568261	0.333333333333	BAK1 BAX	Non-small cell lung cancer
WP:WP4255	0.0133332445565	0.333333333333	BAK1 BAX	Non-small cell lung cancer
GO:0038034	0.0140408309691	0.5	BAK1 MCL1 BAX	signal transduction in absence of ligand
GO:0097192	0.0140408309691	0.5	BAK1 MCL1 BAX	extrinsic apoptotic signaling pathway in absence of ligand
KEGG:05214	0.0140958050009	0.333333333333	BAK1 BAX	Glioma
GO:0005740	0.0151221141199	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	mitochondrial envelope
KEGG:05212	0.0153684049392	0.333333333333	BAK1 BAX	Pancreatic cancer
KEGG:05220	0.0166952607135	0.333333333333	BAK1 BAX	Chronic myeloid leukemia
GO:0012501	0.0169516363243	1.0	BAK1 BCL2L12 BBC3 BAX MCL1 PMAIP1	programmed cell death
WP:WP4263	0.0187442252959	0.333333333333	BAK1 BAX	Pancreatic adenocarcinoma pathway
GO:0051881	0.0207293189685	0.5	BAK1 PMAIP1 BAX	regulation of mitochondrial membrane potential
GO:0080135	0.0224419840427	0.833333333333	PMAIP1 BAK1 BBC3 MCL1 BAX	regulation of cellular response to stress
GO:0051204	0.0239073169747	0.5	BAX BBC3 PMAIP1	protein insertion into mitochondrial membrane
GO:1901216	0.0239073169747	0.5	BAX MCL1 BBC3	positive regulation of neuron death
WP:WP4658	0.02454095485	0.333333333333	BAK1 BAX	Small cell lung cancer
MIRNA:hsa-miR-643	0.0247626201407	0.333333333333	BCL2L12 PMAIP1	hsa-miR-643
MIRNA:hsa-miR-125a-5p	0.0247887156311	0.5	BAK1 MCL1 BCL2L12	hsa-miR-125a-5p
CORUM:2000	0.0249904952816	0.166666666667	BAX	BAX homo-oligomer complex
CORUM:3492	0.0249904952816	0.166666666667	BAX	BAX homo-oligomer complex
KEGG:05222	0.0257907962007	0.333333333333	BAK1 BAX	Small cell lung cancer
GO:0008219	0.0263661961424	1.0	BAK1 BCL2L12 BBC3 BAX MCL1 PMAIP1	cell death
GO:0006839	0.0364891183251	0.666666666667	PMAIP1 BAK1 BBC3 BAX	mitochondrial transport
REAC:R-HSA-3700989	0.0393483138606	0.5	BAX BBC3 PMAIP1	Transcriptional Regulation by TP53
GO:0051434	0.0405595771497	0.333333333333	BAX MCL1	BH3 domain binding
GO:0051400	0.0405595771497	0.333333333333	BAX MCL1	BH domain binding
GO:0051205	0.0422297014162	0.5	BAX BBC3 PMAIP1	protein insertion into membrane
GO:0034976	0.0497114859614	0.666666666667	PMAIP1 BAK1 BBC3 BAX	response to endoplasmic reticulum stress

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BAK1	MCL1	0.998	0.939	bioplex (MCL1)
MCL1	BBC3	0.628	0.68	bioplex (MCL1)
MCL1	BAX	0.273	0.487	bioplex (MCL1) bioplex_WMM
MCL1	PMAIP1	0.242	0.468	bioplex (MCL1)
BAX	BCL2L12	0.026	0.218	bioplex (BCL2L12) bioplex_WMM
BAX	BBC3	0.01	0.098	bioplex_WMM WMM_only
BAK1	BBC3	0.009	0.104	bioplex_WMM WMM_only
BAK1	PMAIP1	0.009	0.095	bioplex_WMM WMM_only
BBC3	PMAIP1	0.008	0.091	bioplex_WMM WMM_only
BAK1	BAX	0.008	0.089	bioplex_WMM WMM_only
BAX	PMAIP1	0.008	0.07	bioplex_WMM WMM_only

Images

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Complex HuMAP2_00283 has an average edge precision of 0.304 which is ranked 4530 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BAK1	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310
MCL1	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_05310 HuMAP2_05402 HuMAP2_06133
BAX	HuMAP2_00283 HuMAP2_00612 HuMAP2_01697 HuMAP2_02045 HuMAP2_06133
BCL2L12	HuMAP2_00283
BBC3	HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_06133 HuMAP2_06564
PMAIP1	HuMAP2_00283 HuMAP2_00612 HuMAP2_04371

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_00283